Leukemic infiltration of the breast in acute lymphocytic leukemia (ALL)

Karbasian-Esfahani, Merat; Wiernik, Peter H.; Yeddu, Mrilini; Abebe, Lool

doi:10.1179/102453308x315933

Cited by 17 publications

(10 citation statements)

References 22 publications

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“…The mechanism of extramedullary infiltration is unclear. In studies of extramedullary AML, the expression of adhesion molecules such as CD56 was associated with extramedullary granulocytic sarcoma, which occurred in 3% to 7% of AML cases [56]. …”

Section: Discussionmentioning

confidence: 99%

Relapse of Biphenotypic Acute Leukemia as a Breast Mass

Shin

2016

J Breast Cancer

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In acute leukemia, leukemic infiltration of the breast is extremely rare. We report a case of biphenotypic acute leukemia (BAL) that presented as a breast mass. A 30-year-old woman presented with a 4-month history of a right breast mass with nipple discharge and easy fatigue. She had received chemotherapy and peripheral blood stem cell transplantation for BAL and had been in complete remission for the last 2 years. Core needle biopsy of the breast mass revealed monomorphous infiltrates of blast cells with round nuclei and fine chromatin, consistent with leukemic infiltration. Subsequent bone marrow biopsy showed diffuse infiltration of immature cells. However, bone marrow karyotyping showed 46, XY, suggesting complete engraftment of transplanted donor cells. This is the report of BAL recurring as a breast mass. In the differential diagnosis of a breast mass, extramedullary relapse should be considered when the patient has a history of leukemia.

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Section: Discussionmentioning

confidence: 99%

Relapse of Biphenotypic Acute Leukemia as a Breast Mass

Shin

2016

J Breast Cancer

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“…The median age in those patients was16 years [3]. Four cases with similar presentation of adultALL have been published (Table 1) [4,5,6,7]. Sagar et alreported a similar occurrence in a 35-year-old female, butdetails on immunophenotyping, response, remission status,and outcome were not available [4].…”

Section: To the Editormentioning

confidence: 99%

“…Chim et al reported asimilar case in a 23-year-old male with previous diagnosis ofT-cell ALL who died of progressive disease after 7 months ofrelapse [5]. Two other cases with similar presentation havebeen reported [6,7]. All patients reported with adult ALLwere between the ages of 23 and 35 years.…”

Section: To the Editormentioning

confidence: 99%

Isolated Breast Relapse Mimicking Breast Cancer in Elderly Patient with Acute Lymphoblastic Leukemia

Gogia

Mehta

Pramanik

et al. 2014

Tjh

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“…[1] Patients with lymphoblastic or leukemic infiltration of the breast usually present with a palpable lesion that is generally well circumscribed and rapidly enlarging. The lesion may be bilateral and/or multifocal simulating a fibroadenoma.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of secondary involvement of the breast by lymphoreticular malignancy from fibroadenoma using ultrasound elastography: A report of two cases

Eren

Ertan

Ulus

2017

Indian Journal of Radiology and Imaging

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Extramedullary lymphoma infiltration of the breast by lymphoblastic lymphoma is very rare and most cases are of B-cell lineage; T-cell neoplasms represent less than 10% of all breast lymphomas. Here, we report one patient with lymphoblastic lymphoma and one patient with leukemia, who have similar lesions in breasts with different ultrasound elastography findings. Ultrasound-guided tru-cut biopsies were performed and the first lesion was confirmed as lymphoma infiltration and the second as fibroadenoma. In cases of breast mass presence in patients with a history of hematologic malignancies such as lymphoma or leukemia, breast infiltration should be kept in mind. Elastography findings can assist in the differentiation of these lesions and further investigations or biopsies can be avoided.

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Leukemic infiltration of the breast in acute lymphocytic leukemia (ALL)

Cited by 17 publications

References 22 publications

Relapse of Biphenotypic Acute Leukemia as a Breast Mass

Relapse of Biphenotypic Acute Leukemia as a Breast Mass

Isolated Breast Relapse Mimicking Breast Cancer in Elderly Patient with Acute Lymphoblastic Leukemia

Differentiation of secondary involvement of the breast by lymphoreticular malignancy from fibroadenoma using ultrasound elastography: A report of two cases

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