Leukemia Cutis Presenting as a Sister Mary Joseph Nodule

Beynet, David; Oro, Anthony E.

doi:10.1001/archderm.140.9.1170

Cited by 8 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Legs are most commonly involved, followed by the arms, back, chest, scalp and face 5 . However, other presentations have been reported including symmetrical edematous facial erythema, 8 vitiligo, 9 stasis–dermatitis‐like eruption, 10 Sister Mary Joseph's nodule, 11 localized cutaneous hyperpigmentation, fingertip hypertrophy, chronic genital ulcers, circinate plaques in juvenile chronic myeloid leukemia, bilateral eyelid infiltration, leukemic vasculitis, ulcers in herpes zoster scars, ecchymoses, ulcerative balanoposthitis, vaginal ulcers and psoriasis‐like lesions 12 . Leukemia cutis is a manifestation of an underlying systemic disease, and therefore treatment is aimed at eradicating the systemic disease by using systemic and local chemotherapy 5 …”

Section: Discussionmentioning

confidence: 99%

Angioinvasive Fusarium and concomitant Enterococcus infection arising in association with leukemia cutis

Feramisco

Hsiao

Fox

et al. 2011

Journal of Cutaneous Pathology

View full text Add to dashboard Cite

Leukemia cutis represents the cutaneous infiltration of neoplastic leukocytes or their precursors that results in clinically identifiable skin lesions. For patients with myelodysplastic syndrome, developing such a lesion may indicate impending leukemic transition. These patients are also often immunocompromised, putting them at risk for infection by opportunistic fungal pathogens such as Fusarium. We describe an 85-year-old man with myelodysplastic syndrome who presented with a reddish-purple nodule with a surrounding erythematous plaque on his shin. Histopathologic examination revealed a dense diffuse infiltrate of large atypical cells in the reticular dermis, with ulceration and necrosis. Immunohistochemical studies showed positive staining with CD15, CD68 and myeloperoxidase of constituent large cells. Concurrently, there were branching and septate hyphae with occasional macroconidia-like structures throughout the infiltrate. Cultures from this lesion grew Fusarium and Enterococcus, supporting the diagnosis: leukemia cutis with superinfection involving both Fusarium and Enterococcus. To our knowledge, this is a novel report of two separate infections occurring in a lesion of leukemia cutis. This case shows that in patients with a hematologic malignancy and skin lesions, a high index of suspicion for infection is necessary when reviewing both the clinical and histopathological data to avoid overlooking an important occult infectious agent.

show abstract

Section: Discussionmentioning

confidence: 99%

Angioinvasive Fusarium and concomitant Enterococcus infection arising in association with leukemia cutis

Feramisco

Hsiao

Fox

et al. 2011

Journal of Cutaneous Pathology

View full text Add to dashboard Cite

show abstract

“…Other less frequent forms of presentation of leukemia cutis include erythrodermia and prurigo‐like eruption with pruritus. Additional more rare forms of presentation of leukemia cutis include fingertip hypertrophy, 3 chronic genital ulcer, 4 circinate plaques in juvenile chronic myeloid leukemia, 5 bilateral eyelid infiltration, 6 leukemic vasculitis, 7 sister Mary Joseph’s nodule, 8 ulcers in herpes zoster scars, 9 echymoses, 10 ulcerative balanoposthitis, 11 vaginal ulcers 12 and psoriasis‐like lesions 13 . Our patient presented localized bluish hyperpigmentation of the skin of the upper trunk and temporal areas of the forehead and cutaneous lesions showed no infiltration of the skin from a clinical point of view.…”

Section: Discussionmentioning

confidence: 99%

Leukemia cutis presenting as localized cutaneous hyperpigmentation

et al. 2008

View full text Add to dashboard Cite

The usual clinical presentations of leukemia cutis include solitary infiltrated erythematous or violaceous plaques or nodules and multiple localized or generalized papules. On the other hand, cutaneous hyperpigmentation is a frequent finding in patients with malignancies, most of the cases because of chemotherapy or other drugs that the patient is taking. We present a case of cutaneous hyperpigmentation as the presenting sign of leukemia cutis. A 61-year-old male presented with cutaneous hyperpigmentation, which had appeared during the last chemotherapy cycle for treatment for biphenotypic leukemia. Cutaneous lesions consisted of bluish to brownish irregular well-defined discoloration of the skin involving the upper part of the trunk and the temporal regions of the forehead. The patient was asymptomatic and the skin was not infiltrated at all. However, histopathologic study showed nodular infiltrates involving the full-thickness of the dermis and destroying pre-existing adnexa. This infiltrate was composed of atypical basophilic cells with large hyperchromatic nuclei and scant cytoplasm. Immunohistochemical studies showed intense immunoexpression for CD43, CD68, CD45RO and myeloperoxidase within these cells. A diagnosis of biphenotypic leukemia cutis was established. In our review of the literature we have not found any report of cutaneous hyperpigmentation as the presenting manifestation of leukemia cutis.

show abstract

“…Non-Hodgkin's lymphoma and acute myeloid leukemia have been reported to involve the umbilicus, often causing a rapidly growing ulcerative mass [11][12][13][14][15]. Metastatic deposits to the umbilical area are commonly referred to as Sister Mary Joseph's nodule, named after a Mayo Clinic nurse who prepared patient's abdomens for surgery and noted a correlation between periumbilical mass lesions and intraabdominal malignancy [15]. Metastatic umbilical tumors may be the first sign of internal malignancy or occur during the course of known malignancy.…”

Section: Umbilical Tumorsmentioning

confidence: 99%

Umbilical Complications of Malignancy

Marinella

2008

J Gastrointest Canc

View full text Add to dashboard Cite

Umbilical metastases (Sister Mary Joseph's sign) are the most common malignant complication involving the umbilicus and may be the presenting manifestation of visceral malignancy. Cancer patients may occasionally experience periumbilical ecchymosis (Cullen's sign), infection, hernia, or varices, each of which may require therapy. This review succinctly presents several umbilical complications that the clinician may encounter in patients with malignant disease.

show abstract

Leukemia Cutis Presenting as a Sister Mary Joseph Nodule

Cited by 8 publications

References 3 publications

Angioinvasive Fusarium and concomitant Enterococcus infection arising in association with leukemia cutis

Angioinvasive Fusarium and concomitant Enterococcus infection arising in association with leukemia cutis

Leukemia cutis presenting as localized cutaneous hyperpigmentation

Umbilical Complications of Malignancy

Contact Info

Product

Resources

About