Leukemia cutis in acute myelomonocytic leukemia. Preferential localization in a recent Hickman catheter scar

Leukemia Cutis in Acute Myelomonocytic Leukemia: Infiltration to Minor Traumas and Scars

“…In addition, leukemia cutis may be the first sign of the blastic leukemic transformation of myelodysplastic syndrome (6,8,9). There have been several reported cases of leukemia cutis as the initial manifestation of leukemia relapse or as a precursor ofleukemia cell appearance in the peripheral blood (6,8,10). Cutaneous infiltration by leukemic cells is regarded as one sign of a poor prognosis (2).…”

“…As local cutaneous factors, skin injury and inflammation may play significant roles in leukemic cell infiltration. Although leukemic skin infiltration is usually disseminated widely over the body, leukemia cutis may arise in scars from recent surgery, trauma, burns, herpes zoster, and herpes simplex (locus minoris) (5,10). It may also be seen at the sites of intramuscular injection (5).…”

Leukemia cutis originating in the extravasation site of i.v. gabexate mesilate infusion

“…Growth of leukemia cutis does not favor any particular site, but secondary occurrences on injured sites such as burn scars, traumata, herpes zoster eruption sites and surgical scars have been reported. 1,2 To our knowledge, there are no prior cases of the occurrence of leukemia cutis or of skin metastases at the site of the extravasation of gabexate mesilate.…”

A Case of Leukemia Cutis at the Site of a Prior Catheter Insertion

“…Leukemia cutis in ALL commonly presents as single or multiple, red-to-violaceous papules or nodules on the head and neck 7 . Although leukemia cutis often presents as disseminated lesions, localization to sites of minor trauma, scars, as well as Hickman catheter sites have rarely been reported, thus the incidence is not known [2][3][4] . Also, in solid organ cancers, such as head and neck cancer, thymic cancer, or lung cancer, tumor metastasis to the sites of gastrostomy or needle biopsy tracts have been reported.…”

“…The lesions may be localized or disseminated, and can occur at any site on the skin. However, there are some reports of leukemia cutis at sites of previous trauma, burns, and herpetic infections [2][3][4][5] . To date, only three cases of leukemia cutis at a site with prior trauma have been reported in patients with acute leukemia (Table 1).…”