Leukemia Cutis: A Presenting Sign in Acute Promyelocytic Leukemia

Markowski, Tania R.

doi:10.1001/archderm.143.9.1220

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…The negative reactivity for leukocyte common antigen, CD20, CD3, CD45RO and CD45RA rules out obvious lymphoid malignancies. The nearly perfect reticular pattern throughout a lesion together with the presence of eosinophilic myelocytes favor the diagnosis of leukemic infiltrates 178 …”

Section: Skin Metastasis Of Hematological Malignanciesmentioning

confidence: 99%

Skin metastasis: a pathologist's perspective

2010

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Skin metastasis is defined as the spread of malignant cells from a primary malignancy to the skin. It is one manifestation of systemic spread of cancer. The tumor cells originate either from an internal malignancy or from a primary skin cancer. This study presents a literature review concerning these issues as well as this author's experience encountered throughout 19 years of surgical pathology and dermatopathology practice. Several conclusions are evident. Generally, skin metastases are encountered in 0.7-9% of all patients with cancer and as such the skin is an uncommon site of metastatic disease when compared to other organs. There is usually a long-time lag between the diagnosis of the primary malignancy and the recognition of the skin metastases. However, these metastases may be the first indication of the clinically silent visceral malignancies. The regional distribution of the skin metastasis, although not always predictable, is related to the location of the primary malignancy and the mechanism of metastatic spread. The relative frequency of skin metastasis correlates with the type of primary cancer, which occurs in each sex. For instance, lung and breast carcinomas are the most common primaries that send skin metastasis in men and women, respectively. The head and neck region and the anterior chest are the areas of greatest predilection in men. The anterior chest wall and the abdomen are the most commonly involved sites in women. Skin metastases usually appear as non-specific groups of discrete firm painless nodules that emerge rapidly without any explanation. They vary in size from so tiny as to be of 'miliary lesions' to as large as 'Hen's egg size'. Some skin metastasis may mimic specific dermatological conditions such as cutaneous cyst, dermatofibroma, pyogenic granuloma, hemangioma, papular eruptions, herpes zoster eruptions, rapidly infiltrating plaques, alopecic patches, cellulitis and erysipelas. Histologically, the skin metastases usually show features reminiscent of the primary malignancy, but with variable degrees of differentiation. Molecularly, skin metastasis is an organized, non-random and organ-selective process orchestrated by interaction among several heterogeneous molecules, which are largely unknown. Metastasis to the skin is often a pre-terminal event that heralds poor outcome.

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Section: Skin Metastasis Of Hematological Malignanciesmentioning

confidence: 99%

Skin metastasis: a pathologist's perspective

2010

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“…However, skin manifestations can occasionally occur in the absence of systemic symptoms, such as this case, or even before peripheral blood or bone marrow involvement. [5][6][7] The presence of leukemia cutis generally suggests that there are other sites of extramedullary involvement, thereby indicating a poorer prognosis. 7,8 Treatment for leukemia cutis is systemic chemotherapy aimed at the underlying type of leukemia.…”

Section: Leukemia Cutis Masquerading As a Chemical Burnmentioning

confidence: 99%

Leukemia cutis masquerading as a chemical burn

Waller

Hughes

Boh

2011

Journal of the American Academy of Dermatology

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“…Various skin diseases can be associated with leukemia, and some can occur as the presenting sign of leukemia. These include leukemia cutis, pyoderma gangrenosum, erythema nodosum, and chronic urticaria [7][8][9][10][11][12] . However, OHL has never been reported as the presenting sign of leukemia.…”

Section: Discussionmentioning

confidence: 99%

Oral Hairy Leukoplakia Which Occurred as a Presenting Sign of Acute Myeloid Leukemia in a Child

et al. 2010

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Oral hairy leukoplakia (OHL) is caused by the reactivation of a previous Epstein-Barr virus (EBV) infection in the epithelium of the tongue. Most lesions are characterized by corrugated whitish patches on the lateral border of the tongue. It is frequently associated with AIDS, but cases in patients with other immunosuppressed states have also been reported. In leukemia patients, OHL is rarely encountered, and appears only after chemotherapy. We report a case of OHL which occurred as a presenting sign of acute myeloid leukemia (AML) in a previously healthy 15-year-old child. A 15-year-old boy presented with a whitish patch on the left lateral border of the tongue. The biopsy specimen revealed papillomatosis, hyperkeratosis, acanthosis and ballooning degeneration in the stratum spinosum. The patient was EBV seropositive, and PCR analysis of EBV DNA in the lesional tissue was positive. After the diagnosis of OHL in dermatologic department, the patient was referred to pediatrics due to the abnormal peripheral blood smear, and was diagnosed with AML. (Ann Dermatol 22(1) 73∼76, 2010)

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Leukemia Cutis: A Presenting Sign in Acute Promyelocytic Leukemia

Cited by 6 publications

References 4 publications

Skin metastasis: a pathologist's perspective

Skin metastasis: a pathologist's perspective

Leukemia cutis masquerading as a chemical burn

Oral Hairy Leukoplakia Which Occurred as a Presenting Sign of Acute Myeloid Leukemia in a Child

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