Leucoencefalopatia multifocal progressiva e paracoccidioidomicose disseminada em paciente com AIDS

Lambertucci, José Roberto; Vale, Thiago Cardoso; Voieta, Izabela

doi:10.1590/s0037-86822010000600037

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the second controlled study, Almeida et al 2016, reported thirty-one HIV-infected patients with PCM between 1993 and 2014 [17]. After compiling the data from these two case-control studies [16,17], two case-series reports [13,18], and 30 single case reports [10,14,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35], we retrieved 136 cases of PCM and HIV coinfection reported in the last 30 years. They aged between 13 and 59 years, with a mean age of 35.9 years.…”

Section: Resultsmentioning

confidence: 99%

Paracoccidioidomycosis in Immunocompromised Patients: A Literature Review

Almeida

Peçanha-Pietrobom

Colombo

2018

JoF

View full text Add to dashboard Cite

Paracoccidioidomycosis (PCM) is an endemic mycosis found in Latin America that causes systemic disease mostly in immunocompetent hosts. A small percentage of PCM occurs in immunocompromised patients where low clinical suspicion of the infection, late diagnosis, and uncertainties about its management are factors that negatively impact their outcomes. We conducted a literature review searching reports on PCM associated to HIV, cancer, maligned hemopathies, solid organ transplantation, and immunotherapies, in order to check for peculiarities in terms of natural history and challenges in the clinical management of PCM in this population. HIV patients with PCM usually had low T CD4+ cell counts, pulmonary and lymph nodes involvement, and a poorer prognosis (≈50% mortality). Most of the patients with PCM and cancer had carcinoma of the respiratory tract. Among maligned hemopathies, PCM was more often related to lymphoma. In general, PCM prognosis in patients with malignant diseases was related to the cancer stage. PCM in transplant recipients was mostly associated with the late phase of kidney transplantation, with a high mortality rate (44%). Despite being uncommon, reactivation of latent PCM may take place in the setting of immunocompromised patients exhibiting clinical particularities and it carries higher mortality rates than normal hosts.

show abstract

Section: Resultsmentioning

confidence: 99%

Paracoccidioidomycosis in Immunocompromised Patients: A Literature Review

Almeida

Peçanha-Pietrobom

Colombo

2018

JoF

View full text Add to dashboard Cite

show abstract

Paracoccidioidomycosis in Brazilian Patients With and Without Human Immunodeficiency Virus Infection

Almeida¹,

Neves²,

Mora³

et al. 2017

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Paracoccidioidomycosis (PCM) is endemic to Latin America, where 10 million people may be infected with Paracoccidioides brasiliensis/Paracoccidioides lutzii and 1,600,000 individuals live with human immunodeficiency virus (HIV) infection. An epidemiological overlapping of these infections occurred early in acquired immunodeficiency syndrome era with nearly 180 published cases. This study presents epidemiological, clinical, and outcome profiles for 31 PCM patients with HIV infection diagnosed in a teaching hospital in Brazil, and includes an update of previously reported cases. Medical records were reviewed and data compared with 64 PCM patients without HIV infection. Of the 31 PCM patients with HIV infection, 23 (74.1%) were male, with a median age of 36.7 years, whereas of the 64 PCM, 45 (70.3%) were male, with a median age of 35.1 years. Both groups presented similar proportions for smoking and alcoholism. PCM patients with HIV infection presented more fever, weight loss, and the acute clinical form than the PCM patients who had more mucosal and respiratory involvement characterizing the chronic form. Most PCM patients with HIV infection exhibited overlapping symptoms from both clinical forms with median symptom duration of 4.5 months compared with 8.3 months for the PCM control. Patients received sulfonamides and/or itraconazole for a median of 15.7 and 16.7 months for PCM/HIV-infected and PCM, respectively. Relapses occurred more in PCM (12 [30%]) than PCM/HIV-infected (4 [14.8%]) patients, whose mortality rate was higher (10 [32.8%]) than PCM patients (8 [20%]). The cases of PCM/HIV infection confirm that HIV can interact with some endemic diseases without increasing their frequency, while changing their natural history, clinical presentation, and outcome. The data presented here are in agreement with those observed in other studies.

show abstract

Leucoencefalopatia multifocal progressiva e paracoccidioidomicose disseminada em paciente com AIDS

Cited by 2 publications

References 2 publications

Paracoccidioidomycosis in Immunocompromised Patients: A Literature Review

Paracoccidioidomycosis in Immunocompromised Patients: A Literature Review

Paracoccidioidomycosis in Brazilian Patients With and Without Human Immunodeficiency Virus Infection

Contact Info

Product

Resources

About