Letters to the Editor

Walder, Emily J.

doi:10.1354/vp.42-1-107-a

Cited by 2 publications

(1 citation statement)

References 11 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 In a recent letter to the editor of Veterinary Pathology, it was recommended that these tumors be referred to as clear cell or balloon-cell sweat gland carcinomas on the basis of an unpublished study demonstrating immunohistochemical positivity for CAM5.2 in 6 of 6 tumors tested and the author's opinion that these neoplasms have a close analog in human malignant nodular hidradenoma. 19 Limited immunohistochemical studies on cytokeratin subtypes in canine skin and tumors have been reported. 2,15,21 To the best of the au-thors' knowledge, there is nothing in the peer-reviewed literature to support the contention that immunohistochemistry for CAM5.2 or any other keratin subtype can differentiate between canine adnexa or adnexal neoplasms in formalin-fixed tissue.…”

Section: Discussionmentioning

confidence: 99%

Canine Cutaneous Clear Cell Adnexal Carcinoma: Histopathology, Immunohistochemistry, and Biologic Behavior of 26 Cases

2005

View full text Add to dashboard Cite

Thirty tumors including 27 distinctive cutaneous neoplasms and 3 metastatic tumors from 26 dogs were collected from diagnostic submissions to 3 laboratories. Characteristic histopathologic features included location in the subcutis or dermis (or both); lobular, nodular, and nest-like architecture; and a component of epithelioid cells with clear cytoplasm. Additional features present in most cases included follicular dermal papilla-like structures, low mitotic index, nuclear pleomorphism, necrosis, and mineralization. Cytoplasmic periodic acid Schiff-positivity, which was abolished by pretreatment with diastase, indicated the presence of glycogen in all cases. The oil red O stain did not demonstrate cytoplasmic lipid. Melanin granules, accentuated by the Fontana-Masson method, were observed infrequently. A sparsely cellular mucinous stroma and stromal cartilaginous differentiation were uncommon. By immunohistochemistry, neoplastic cells stained positively for cytokeratin (29 of 29), vimentin (28 of 28), S-100 protein (24 of 29), and melan A (8 of 12); results were negative for smooth muscle actin and calponin in all cases. Clinical follow-up information was obtained on all 26 dogs. One tumor recurred, 1 metastasized to a regional lymph node, and 1 metastasized to regional lymph nodes twice. In another case, possible pulmonary metastasis was noted radiographically. The findings are consistent with a poorly differentiated, low-grade, adnexal carcinoma of the skin. Similar canine cutaneous neoplasms have been reported as "clear-cell hidradenocarcinoma" and "follicular stem cell carcinoma." The authors propose the designation "cutaneous clear cell adnexal carcinoma."

show abstract