Letter: Treatment of plantar warts with bleomycin

Al, Hudson

doi:10.1001/archderm.112.8.1179c

Cited by 24 publications

(6 citation statements)

References 0 publications

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“…By the use of a Pan-jet injector (Schuco Inc.) de livering 0.1 ml per injection better clinical results are obtainable when administering bleomycin in saline. Hudson [4] obtained clearing of warts in 84% of his cases. An aqueous solution of bleomycin injected in tradermally is thus satisfactory in the treat ment of warts.…”

Section: Introductionmentioning

confidence: 95%

Locally Injected Bleomycin in the Treatment of Warts

Munkvad¹,

Genner²,

Staberg³

et al. 1983

Dermatology

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Section: Introductionmentioning

confidence: 95%

Locally Injected Bleomycin in the Treatment of Warts

Munkvad¹,

Genner²,

Staberg³

et al. 1983

Dermatology

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“…When these types of studies were not available for this review, studies with adequate controls and/or repeatability stability data were selected. Despite these efforts, it was still difficult to directly compare each of the reports with one another, because of the diversity in reported stability data presented and absence of comprehensive information in the literature, such as: inconsistency or lack of reporting of controls, repeatable data, and/or validation methods; missing information; different assay techniques; lack of reporting of assay techniques; various times for study endpoint; diverse definition of stability; variation in storage times for the same drug; etc. Future studies that address these inconsistencies would be helpful.…”

Section: Discussionmentioning

confidence: 99%

“…A radioimmunoassay stability study showed that bleomycin (1 mg/mL) frozen at −20 °C in glass was stable (>97% bleomycin) for up to 27 months, and for up to 9.5 months when stored in plastic (because of adsorption to plastic) . Other studies report 6–8 weeks of stability of 1% bleomycin in 0.9% NaCl at 4 °C, and 4 weeks for bleomycin solution stored in glass vials at 5 °C . A cell survival biological assay reported 80–95% cell kill efficacy of bleomycin (0.03 mg/mL in 0.9% NaCl) after storage in glass containers for up to 3 weeks at 4, −20 and −70 °C .…”

Section: Bleomycinmentioning

confidence: 99%

A literature review of reports of the stability and storage of common injectable chemotherapy agents used in veterinary patients

Chan¹,

Frimberger²,

Moore³

2016

Vet Comparative Oncology

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Many chemotherapy drugs used in human patients are discarded after single use or within 24 h of reconstitution, as per the manufacturer's product label recommendations. This can be wasteful and costly to veterinary clients. This report reviews the published stability and storage data for 19 injectable chemotherapy drugs commonly used in veterinary medicine. Based on these data, storage procedures are presented, assuming aseptic technique and a closed system drug transfer device (CSDTD) are used for drug preparation and handling. Further studies on the risk of microbiological contamination of chemotherapeutics using a CSDTD, and validated high quality drug assays such as stability-indicating high-performance liquid chromatography, are required. The authors' intent is not to supersede product label recommendations, but to suggest that longer storage without significant loss of drug efficacy may be possible, thus reducing the costs of chemotherapeutics to some veterinary clients.

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“…The basis for wart therapy should not rely solely on collective efficacy data but also on patient satisfaction. 4 Many studies have shown bleomycin to be an effective modality for warts 5-36 ; however, documentation of patient satisfaction with bleomycin therapy is lacking. We evaluate the efficacy of intralesional bleomycin therapy for warts in conjunction with patient satisfaction.…”

Section: Introductionmentioning

confidence: 99%