Letter to the Editor: “Reversible cardiomyopathy associated with acute inhaled marijuana use in a young adult”

Ting, Joseph

doi:10.1080/15563650601073587

Cited by 25 publications

(14 citation statements)

References 10 publications

(16 reference statements)

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“…Rarely, development of stress cardiomyopathy has been temporally related to consumption of cannabis (75). Recurrent stress cardiomyopathy involving cardiac apical and basal cardiac regions on two separate occasions in the same patient has also been reported.…”

Section: Takotsubo Cardiomyopathymentioning

confidence: 93%

Role of cannabis in cardiovascular disorders

2017

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The growing popularity of medical and recreational consumption of cannabis, especially among the youth, raises immediate concerns regarding its safety and long-terms effects. The cardiovascular effects of cannabis are not well known. Cannabis consumption has been shown to cause arrhythmia including ventricular tachycardia, and potentially sudden death, and to increase the risk of myocardial infarction (MI). These effects appear to be compounded by cigarette smoking and precipitated by excessive physical activity, especially during the first few hours of consumption. Cannabinoids, or the active compounds of cannabis, have been shown to have heterogeneous effects on central and peripheral circulation. Acute cannabis consumption has been shown to cause an increase in blood pressure, specifically systolic blood pressure (SBP), and orthostatic hypotension. Cannabis use has been reported to increase risk of ischemic stroke, particularly in the healthy young patients. The endocannabinoid system (ECS) is currently considered as a promising therapeutic target in the management of several disease conditions. Synthetic cannabinoids (SCs) are being increasingly investigated for their therapeutic effects; however, the value of their benefits over possible complications remains controversial. Despite the considerable research in this field, the benefits of cannabis and its synthetic derivatives remains questionable even in the face of an increasingly tolerating attitude towards recreational consumption and promotion of the therapeutic complications. More efforts are needed to increase awareness among the public, especially youth, about the cardiovascular risks associated with cannabis use and to disseminate the accumulated knowledge regarding its ill effects.

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Section: Takotsubo Cardiomyopathymentioning

confidence: 93%

Role of cannabis in cardiovascular disorders

2017

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“…Additionally, review articles refer to the first hour after cannabis smoking as the riskiest hour, with the risk falling rapidly thereafter . Several authors have reported cases of CVD in proximity to cannabis use, sometimes supported by a positive urinalysis, as reported in Table . However, a positive cannabis finding is common up to 5 days after smoking and, in heavy smokers, positivity may be present for weeks or months .…”

Section: Introductionmentioning

confidence: 99%

Coronary thrombosis and marijuana smoking: a case report and narrative review of the literature

Marchetti

Matteis

et al. 2015

Drug Testing and Analysis

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We encountered evidence of myocardial infarction due to coronary thrombosis in an autopsy of an occasional marijuana smoker. These findings prompted us to perform a narrative review of the literature to determine when post-mortem toxicological tests may support a temporal relationship between marijuana smoking and cardiovascular disease. Toxicological examination showed the presence of Δ-9-tetrahydrocannabinol, its main metabolite and cannabinol in blood and urine. Quali-quantitative analysis revealed that Δ-9-tetrahydrocannabinol was taken within 2 h of the onset of cardiovascular symptoms, according to circumstantial data. Post-mortem toxicological results must take into account the degradation and post-mortem redistribution of analytes. However, for any inference about the specific cardiovascular triggering effect of Δ-9-tetrahydrocannabinol intake, we maintain that cannabinoid analysis in blood samples must be considered an essential requirement to estimate the time of last intake and avoid incomplete documentation. The literature, combined with the present case report, highlights an association between marijuana use and negative cardiovascular events, although few authors have supported their conclusions with toxicological results. Thus, additional research is needed.

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“…Reversible cardiomyopathy and ventricular tachycardia can be associated with chronic inhalation of marijuana,97) high dose interleukin-2 treatment,98) and some psychotropic drugs including tricyclic antidepressants, phenothiazine and lithium.…”

Section: Reversible Cardiomyopathiesmentioning

confidence: 99%

Role of Imaging in the Detection of Reversible Cardiomyopathy

Park

Kwon

Starling

et al. 2013

J Cardiovasc Ultrasound

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Heart failure is a major clinical problem in developed countries with about half of heart failure patients exhibiting decreased left ventricular systolic function. The correct identification and prompt treatment of some specific etiologies can reverse heart failure, and recognition of myocardial recovery may avoid long-term therapy. However, the echocardiographic patterns of patients with a variety of etiologies of heart failure are similar, so the selective use of other imaging techniques is necessary for identification of specific etiologies. The role of repeat imaging in monitoring the therapeutic response is controversial, as is the cessation of medical therapy in patients demonstrating recovery.

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Letter to the Editor: “Reversible cardiomyopathy associated with acute inhaled marijuana use in a young adult”

Cited by 25 publications

References 10 publications

Role of cannabis in cardiovascular disorders

Role of cannabis in cardiovascular disorders

Coronary thrombosis and marijuana smoking: a case report and narrative review of the literature

Role of Imaging in the Detection of Reversible Cardiomyopathy

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