Letter: Sezary-like cells in cultures of normal human skin

Ba, Flaxman; Ej, Van Scott; Goldman, Leon

doi:10.1001/archderm.109.4.577

Cited by 23 publications

(7 citation statements)

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“…The considerable variation in the ultrastructure of these cells and the occurrence of similar cells in mycosis fungoides has raised the question of whether this syndrome could be a variant of mycosis fungoides. Flaxman demonstrated such cerebriform cells in non-malignant skin diseases and recently described SCzary-like cells in cultures of normal skin (Flaxman et al, 1971;Flaxman et al, 1974). Our results indicate that the Stzary cells in blood and skin show a variable morphology, as has also been reported by others (Lutzner and Jordan, 1968;Lutzner et al, 1973).…”

Section: Discussionsupporting

confidence: 86%

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Sézary's syndrome: A cytogenetic, cytophotometric and autoradiographic study

Bosman

Vloten

1976

The Journal of Pathology

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Cytophotometric, cytogenetic, and autoradiographic studies were performed in cells of three patients suffering from clinically diagnosed Sézary's syndrome with erythroderma and the presence of abnormal lymphoid cells in the peripheral blood, skin, bone marrow and lymph-nodes. Feulgen DNA cytophotometry of cells in the peripheral blood and skin lesions showed marked aneuploidy and tetraploidy. Multiple translocations were identified with a G-banding technique. The chromosomal abnormalities varied widely between the patients, but C and D group chromosomes were more frequently involved than others. All breakpoints of the translocations were localised in the centromeric region. Autoradiography of blood and skin samples revealed many labelled cells in the skin and a lower number in the blood, indicating cell proliferation in the skin. It is concluded that the pathological cells occurring in the Sézary syndrome are abnormal lymphoid cells with a tendency to proliferate in the dermis. The variability observed between and in the patients is in all probability due to a difference in the degree of dedifferentiation.

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Section: Discussionsupporting

confidence: 86%

“…Due to dedifferentiation, more and more lymphocyte properties are lost while the cell becomes larger and its genetic content more aberrant. This makes the finding of SCzary-like cells in normal skin culture understandable (Flaxman et al, 1974).…”

Section: Discussionmentioning

confidence: 99%

Sézary's syndrome: A cytogenetic, cytophotometric and autoradiographic study

Bosman

Vloten

1976

The Journal of Pathology

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“…Biopsies from these diseases were not available for the present study. Our observations did not support the statements of Flaxman et al (1971Flaxman et al ( ,1974 about the non-specificity of the mycosis cells in general. Their observations did apply to some extent however to the small cell variant.…”

Section: Discussioncontrasting

confidence: 99%

“…This cell was characterized by a high nucleus to cytoplasm ratio, deep and narrow nuclear indentations, chromatin condensed at the nuclear membrane and a cytoplasm poor in organelles. It was at first thought to be specific for mycosis fungoides or Sezary's syndrome, but this is now known not to be the case (Flaxman, Zelazny & Van Scott, 1971;Flaxman, Van Scott & Goldman, 1974). However, the presence of these 'mycosis cells' in sheets and clusters has still be considered to be practically pathognomic of mycosis fungoides .…”

mentioning

confidence: 99%

Mycosis fungoides: a morphological study

Putte

Meer

1981

Clin Exp Dermatol

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Summary Skin biopsies from nineteen biopsy proven patients with mycosis fungoides were studied by using a contrasting dichrome stain in 0.5 μm thin sections, and comparing the results to those of normal skin and non‐lymphomatous dermatoses. An abnormal cellular component was observed in mycosis fungoides, consisting of cells that exhibited a great diversity in cellular morphology. In addition to large and small types of ‘mycosis cells’, variants with less indented nuclei and three types of blast cells were identified. Intermediate forms suggested a process of differentiation. All types showed a basic similarity in form to a normal lymphoid cell of human skin, but they differed by their larger size, more pronounced nuclear grooving and nuclear hyperchromasia.

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“…The question of whether the Sezary cell is a neoplastic cell, a potentially neoplastic cell, or merely a reactive cell has not been settled. The appearance of this cell in patients with non-neoplastic disease, in cultures of normal skin, and in pokeweed-or phytohaemagglutinin-stimulated lymphocyte cultures from healthy human beings points to a non-neoplastic role (Flaxman, Van Scott & Goldman, 1974;Yeckley et aL, 1975). This is also supponed by the presence of circulating lymphokines in patients with Sezary syndrome (Umbert, Belcher & Winkelmann, 1976 (Prunieras, 1974).…”

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confidence: 99%

Circulating Sezary cells in hospitalized dermatology patients

Duncan

Winkelmann

1978

Br J Dermatol

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Sézary cells in the circulation were counted daily in 14 hospitalized dermatology patients: six with contact dermatitis, five with atopic dermatitis, and three with exfoliative psoriasis. All had circulating Sézary cells, but absolute counts of Sézary cells of more than 1000/mm3 appeared to correlate with a severe refractory course in two patients. It is probable that low, intermittent levels of circulating Sézary cells accompany many inflammatory dermatoses, and it is reasonable that monitoring this cell population may aid in anticipating more consequential skin disease.

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Letter: Sezary-like cells in cultures of normal human skin

Cited by 23 publications

References 0 publications

Sézary's syndrome: A cytogenetic, cytophotometric and autoradiographic study

Sézary's syndrome: A cytogenetic, cytophotometric and autoradiographic study

Mycosis fungoides: a morphological study

Circulating Sezary cells in hospitalized dermatology patients

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