Letter: Methoxsalen and irradiation: treatment for pustulosis palmaris et plantaris

Mizune, N; S, Uematsu; Ohno, Morihide

doi:10.1001/archderm.112.6.883b

Cited by 23 publications

(2 citation statements)

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“…therefore. of great interest (2,3,4,5). Considering the localized nature of PPP, systemic psoralen ad ministration would scem to be unwarrantcd, how ever.…”

Section: Discussionmentioning

confidence: 99%

Inefficacy of topical methoxalen plus UVA for palmoplantar pustulosis

Ct¹,

Malmiharju²

1981

Acta Derm Venereol

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The effect of local application of 8-methoxypsoralen (8-MOP) and subsequent UVA irradiation on palmoplantar pustulosis (PPP) was studied in 10 patients. In 8 patients 8-MOP baths were used, and in 5 patients an 8-MOP ointment was applied, 3 patients receiving both forms of treatment. The number of treatment sessions varied from 15 to 128, with maximal UVA doses of 1.2 to 12 J/cm2, and total cumulative doses of 8 to 348 J/cm2. Two patients experienced a brisk phototoxic erythema and one patient developed a bullous reaction. Only 3 patients responded favourably to the treatment, 2 with moderate and 1 with good clearing of the lesions. In the remaining 7 patients either no effect (5 patients) or an exacerbation of the disease (2 patients) was seen.

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“…therefore. of great interest (2,3,4,5). Considering the localized nature of PPP, systemic psoralen ad ministration would scem to be unwarrantcd, how ever.…”

Section: Discussionmentioning

confidence: 99%

Inefficacy of topical methoxalen plus UVA for palmoplantar pustulosis

Ct¹,

Malmiharju²

1981

Acta Derm Venereol

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“…Menne (l) and Mizuno (2) in 12 and 4 cases, respectively. Subsequent reports (3--6), also on small groups of patients, have all been confirmatory.…”

Section: Efficacy Of Puva Therapy For Pustulosis Palmoplantaris Was F...mentioning

confidence: 98%

PUVA therapy for palmoplantar pustulosis

Agren-Jonsson,

Tegner

1985

Acta Derm Venereol

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Forty patients suffering from pustulosis palmoplantaris were treated with PUVA therapy. Thirty-six patients had palmar lesions which cleared in 31 cases; in 18 cases after an initial course of 3 sessions of treatment per week during an average period of 10 weeks, and in another 13 only after additional, less frequent continuation of the PUVA therapy. The average total UVA dose at clearing of the palmar lesions was 191 and the final UVA dose 7.3 J/cm2. After 2 years, 9 out of the 31 cases of palmar lesions were still completely healed, and the average duration of remission was greater than or equal to 15 months. For plantar lesions the results of PUVA therapy, using essentially the same procedure, were less satisfactory: healing being obtained in only 5 out of 34 cases. However, for palmar and plantar lesions alike, most patients have reported long-standing improvement from PUVA therapy. A surprisingly high frequency of nausea was noted as a side-effect.

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