Letter: HL-A antigens in acne conglobata: a negative study

Schackert, K.

doi:10.1001/archderm.110.3.468

Cited by 12 publications

(6 citation statements)

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“… 64 , 65 Human leukocyte antigen genes, cytochrome p450 genes, and even certain glycoproteins have been implicated in the genetic predisposition to acne vulgaris. 66 – 68 Due to the complexity of the pathogenesis of acne, there are likely many heritable factors contributing to the development of acne, and a summary of the cellular events described in this paper is shown in Figure 2 .…”

Section: Geneticsmentioning

confidence: 99%

The epidemiology of acne vulgaris in late adolescence

Lynn

Umari

Dunnick

et al. 2016

AHMT

276

219

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ImportanceAcne vulgaris is the most common skin condition affecting late adolescents across the globe. Although prior studies have evaluated epidemiologic patterns of acne vulgaris in various ethnicities and regions, adequate understanding of the worldwide burden of the disease associated with patients in their late adolescence (15–19-year olds) remains lacking.ObjectiveTo assess the global burden of the disease associated with acne vulgaris for late adolescents (15–19-year olds) and provide an overview of the epidemiology, pathophysiology, and treatment options for acne in this population.DesignDatabase summary study.SettingGlobal Burden of Disease Study 2010 database.ParticipantsGlobal Burden of Disease regions comprised countries with prevalence of acne vulgaris between the ages of 15 and 19 years.Main outcomes and measuresGeographic region-level disability-adjusted life year rates (per 100,000 persons) associated with acne vulgaris in years 1990 through 2010. Median percentage change in disability-adjusted life year rates was estimated for each region across the specified study period.Conclusion and relevanceAcne vulgaris-associated disease burden exhibits global distribution and has continued to grow in prevalence over time within this population. This continued growth suggests an unmet dermatologic need worldwide for this disorder and potential opportunities for improved access and delivery of dermatologic care. Our analysis of the literature reveals numerous opportunities for enhanced patient care. To that end, we highlight some of the effective and promising treatments currently available and address important factors, such as sex, nationality, genetics, pathophysiology, and diet, as they relate to acne vulgaris in late adolescence.

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Section: Geneticsmentioning

confidence: 99%

The epidemiology of acne vulgaris in late adolescence

Lynn

Umari

Dunnick

et al. 2016

AHMT

276

219

View full text Add to dashboard Cite

show abstract

“…An HLA antigen study was negative for acne conglobata [37], but HLA phenotypes were identical in siblings affected with familial acne fulminans [38]. Polymorphism in the human cytochrome P-450 1A1 (CYP1A1) seem to be associated with acne [39], and CYP1A1 is known to be involved in the metabolism of a wide range of compounds such as vitamin A.…”

Section: Acne Geneticsmentioning

confidence: 99%

Acne in Infancy and Acne Genetics

2003

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Acne is a disease that can be seen in the first year of age, early childhood, prepubertal age and puberty. Neonatal acne is due mainly to considerable sebum excretion rate, and infantile acne because of high androgens of adrenal origin in girls and of adrenal and testes in boys. These pathogenic mechanisms are characteristic in these ages. Important factors like early onset of comedones and high serum levels of dehydroepiandrosterone sulfate are predictors of severe or long-standing acne in prepubertal age. Hereditary factors play an important role in acne. Neonatal, nodulocystic acne and conglobate acne has proven genetic influences. Postadolescent acne is related with a first-degree relative with the condition in 50% of the cases. Chromosomal abnormalities, HLA phenotypes, polymorphism of human cytochrome P-450 1A1 and MUC1 gene are involved in the pathogenesis of acne. Several other genes are being studied.

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“…Анализ полиморфизма генов показывает наличие генетической предрасположенности к обоим заболеваниям, по крайней мере, у половины больных [16][17][18][19][20][21][22][23][24][25]. Однако распространенность акне свидетельствует о том, что патогенез заболевания ассоциирован с полиморфностью многих генов [3].…”

Section: общие характеристики розацеа и акнеunclassified

Azelaic acid in the treatment of acne and rosacea

Matushevskaya¹,

Svirshchevskaya²

2018

Klin. dermatol. venerol.

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Акне и розацеа-наиболее распространенные заболевания в практике дерматолога и косметолога. Диагностика и выбор алгоритма терапии представляют определенные трудности. Высокая распространенность, хроническое рецидивирующее течение, выраженные психоэмоциональные расстройства, снижение качества жизни пациентов с акне и розацеа объясняют важность задачи дальнейшего совершенствования терапии. Розацеа Механизмы, вызывающие патологический процесс при розацеа и акне, изучены не конца. Розацеа является хроническим заболеванием кожи с участками покраснения (преимущественно в лицевой области), образованием гнойничковых и других высыпаний. При исследовании RISE, проведенном в России и Германии и включившем соответственно 3013 и 3052 лиц в возрасте 18-65 лет, выявлено 5% больных с розацеа в России и 12%-в Германии [1]. Среди больных розацеа в обеих странах женщины составляли 75% (средний возраст 40 лет), для боль

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Letter: HL-A antigens in acne conglobata: a negative study

Cited by 12 publications

References 0 publications

The epidemiology of acne vulgaris in late adolescence

The epidemiology of acne vulgaris in late adolescence

Acne in Infancy and Acne Genetics

Azelaic acid in the treatment of acne and rosacea

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