Letter: Hematuria following thiabendazole

Golden, Tom

doi:10.1001/archderm.110.2.295b

Cited by 6 publications

(1 citation statement)

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“…However the toxic effects of TBZ were frequently observed in humans (Pawlowski and Skrzypinska, 1972;Golden et al, 1974;Rex et al, 1983;Manivel et al, 1987;Roy et al, 1989;Bion et al, 1995) and animals (Robinson et al, 1965;Ogata et al, 1984;Tada et al, 2001); the toxicity mechanism of TBZ on mammalian system has not been understood. Our study in this work demonstrated that TBZ is a potent inhibitor of porcine mitochondrial SQR with an IC 50 value~100 μmol/L and the interaction motif of TBZ bound to mitochondrial SQR is surprisingly different from all current known SQR inhibitors.…”

Section: Implications From Studying Tbz Inhibition Of Mitochondrial Sqrmentioning

confidence: 99%

Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature

et al. 2011

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The mitochondrial respiratory complex II or succinate: ubiquinone oxidoreductase (SQR) is a key membrane complex in both the tricarboxylic acid cycle and aerobic respiration. Five disinfectant compounds were investigated with their potent inhibition effects on the ubiquinone reduction activity of the porcine mitochondrial SQR by enzymatic assay and crystallography. Crystal structure of the SQR bound with thiabendazole (TBZ) reveals a different inhibitor-binding feature at the ubiquinone binding site where a water molecule plays an important role. The obvious inhibitory effect of TBZ based on the biochemical data (IC 50~1 00 μmol/L) and the significant structure-based binding affinity calculation (~94 μmol/L) draw the suspicion of using TBZ as a good disinfectant compound for nematode infections treatment and fruit storage.

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