1957
DOI: 10.3181/00379727-94-23002 View full text |Buy / Rent full text
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Abstract: Action of an endotoxin in pathogenesis of Cundida alhicans infection has been suggested ( 1.2). This communication reports the lethality for mice of a cell-free supersonic extract of C. albicaizs in combination with chlortetracycline (*\ureomycin. Lederle) and the comparative toxicity of viable C. albicans singly and in combination with chlortetracycline for guinea pigs, rabbits and monkeys.Materials aizd methods. Candida ulbicans, strain 780. was grown on glucose-peptoneyeast-extract agar at 27°C for 72 hours… Show more

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“…The endotoxinlike nature of the complex haptens extracted from the mouse-virulent strains became apparent clinically during the immunization procedures, as reported cursorily earlier (Isenberg, Allerhand, and Berkman, 1963 (Jonsen, Rasch, and Strand, 1955;Jonsen, 1955;Bishop, Blank, and Gardner, 1960) and the observations that virulence of this yeast is associated with a toxic principle (Salvin, 1952;Mourad and Friedman, 1961;Hasenclever and Mitchell, 1962a, b;Roth and Murphy, 1957). The difference between the mouse-avirulent and the mouse-virulent variants is obvious from the immunological reactions with agglutinations, precipitations, and antibody-absorption studies.…”
Section: Methodsmentioning
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“…The endotoxinlike nature of the complex haptens extracted from the mouse-virulent strains became apparent clinically during the immunization procedures, as reported cursorily earlier (Isenberg, Allerhand, and Berkman, 1963 (Jonsen, Rasch, and Strand, 1955;Jonsen, 1955;Bishop, Blank, and Gardner, 1960) and the observations that virulence of this yeast is associated with a toxic principle (Salvin, 1952;Mourad and Friedman, 1961;Hasenclever and Mitchell, 1962a, b;Roth and Murphy, 1957). The difference between the mouse-avirulent and the mouse-virulent variants is obvious from the immunological reactions with agglutinations, precipitations, and antibody-absorption studies.…”
Section: Methodsmentioning
“…The injection of cells or extracts of Candida allicans into appropriate animals results in a variety of physiological reactions such as fever (Braude, McConnell, and Douglas, 1960), shock (Salvin, 1952;Dobias, 1957; Roth and Murphy, 1957; Mourad and Friedman, 1961), leucopenia followed by leucocytosis (Braude et al, 1960), increased resistance to shock ("tolerance";Hasenclever and Mitchell, 1962), and dermal necrosis (Maibach and Kligman, 1962). Although these reactions appear similar to some of those produced by gram-negative bacterial endotoxin (e.g., see Bennett and Cluff, 1957), there is one striking difference.…”
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“…Since any such studies of the genus Candida inevitably become entangled with the problem of toxicity, this also was investigated. Although an endotoxin in C. albicans has been reported, its action was demonstrated only when enhancing substances were added (Salvin, 1952) or when the host was pretreated with antibiotics (Roth and Murphy, 1957).…”
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