Lethal Body Concentrations and Accumulation Patterns Determine Time-Dependent Toxicity of Cadmium in Soil Arthropods

Crommentuijn, Trudie; Doodeman, C.J.A.M.; Doornekamp, A.; Pol, J.J.C. van der; Bedaux, J.J.M.; Gestel, C.A.M. van

doi:10.1897/1552-8618(1994)13[1781:lbcaap]2.0.co;2

Cited by 34 publications

(57 citation statements)

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“…While our estimates of uptake parameters (k 1 and k 1f ) were much smaller than worms exposed to organic compounds, the elimination-parameter estimates (k 2 and k 2f ), however, were consistent with those of a previous study ( Table 2). 31 Similar to results of other TBTK studies, 54,55 elimination parameters were relatively dependent on organisms. Factors causing differences in estimates of uptake parameters are strongly associated with different mechanisms in the bioaccumulation of chemicals.…”

Section: Results and Discussion Tbtk Analysis In Bacteriasupporting

confidence: 69%

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Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>

Yang¹,

Lin²,

Liao³

2017

IJN

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Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of engineered nanomaterials and their nanotoxicity is crucial for human health-risk analysis. Zerovalent iron (Fe 0 ) nanoparticles (NPs) are one of the most prominent NPs applied in remediating contaminated soils and groundwater. However, there are concerns that Fe 0 NP application contributes to long-term environmental and human health impacts. The nematode Caenorhabditis elegans is a surrogate in vivo model that has been successfully applied to assess the potential nanotoxicity of these nanomaterials. Here we present a TBTK/TD approach to appraise bioaccumulation and nanotoxicity of Fe 0 NPs in C. elegans . Built on a present C. elegans bioassay with estimated TBTK/TD parameters, we found that average bioconcentration factors in C. elegans exposed to waterborne and food-borne Fe 0 NPs were ~50 and ~5×10 −3 , respectively, whereas 10% inhibition concentrations for fertility, locomotion, and development, were 1.26 (95% CI 0.19–5.2), 3.84 (0.38–42), and 6.78 (2.58–21) μg·g −1 , respectively, implicating that fertility is the most sensitive endpoint in C. elegans . Our results also showed that biomagnification effects were not observed in waterborne or food-borne Fe 0 NP-exposed worms. We suggest that the TBTK/TD assessment for predicting NP-induced toxicity at different concentrations and conditions in C. elegans could enable rapid selection of nanomaterials that are more likely to be nontoxic in larger animals. We conclude that the use of the TBTK/TD scheme manipulating C. elegans could be used for rapid evaluation of in vivo toxicity of NPs or for drug screening in the field of nanomedicine.

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Section: Results and Discussion Tbtk Analysis In Bacteriasupporting

confidence: 69%

“…56,57 It has been suggested that estimates of uptake parameters generally depend on exposure conditions and medium characteristics. 54 Fe 0 NPs can easily form aggregations in media with higher ionic strength and interact with bacteria, resulting in bioavailability reduction of Fe 0 NPs and alternation of uptake parameters in worms.…”

mentioning

confidence: 99%

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>

Yang¹,

Lin²,

Liao³

2017

IJN

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“…Elimination rate constant for Cd was found to be zero in the isopods Porcellio scaber and Oniscus asellus (Crommentuijn et al, 1994), and low elimination capacity of Cd and Zn was observed in the isopod Porcellio scaber (Vijver et al, 2006). Also for Ag in the isopod Porcellionides pruinosus used in our study, elimination rates were low.…”

Section: Soil Exposurecontrasting

confidence: 54%

“…This is not surprising since k2 will be rather dependent on the organism (Crommentuijn et al, 1994;Díez-Ortiz et al, 2010), while k1 will depend on the exposure conditions, like the available metal concentration and the medium characteristics (Crommentuijn et al, 1994).…”

Section: Soil Exposurementioning

confidence: 99%

Toxicokinetics of Ag in the terrestrial isopod Porcellionides pruinosus exposed to Ag NPs and AgNO3 via soil and food

et al. 2015

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Soares, Amadeu M.V.M.; Loureiro, Susana. 2016. Toxicokinetics of Ag in the terrestrial isopod Porcellionides pruinosus exposed to Ag NPs and AgNO3 via soil and food. Ecotoxicology, 25 (2). 267-278. 10.1007/s10646-015-1585-7 Contact CEH NORA team at noraceh@ceh.ac.ukThe NERC and CEH trademarks and logos ('the Trademarks') are registered trademarks of NERC in the UK and other countries, and may not be used without the prior written consent of the Trademark owner. Isopods were exposed to contaminated Lufa 2.2 soil or alder leaves as food.Uptake and elimination rate constants for soil exposure did not significantly differ between Ag NPs and ionic Ag at 30 and 60 mg Ag/kg. For dietary exposure, the uptake rate constant was up to 5 times higher for Ag NPs than for AgNO3, but this was related to feeding activity and exposure concentrations, while no difference in the elimination rate constants was found. When comparing both routes, dietary exposure resulted in lower Ag uptake rate constants but elimination rate constants did not differ. A fast Ag uptake was observed from both routes and most of the Ag taken up seemed not to be eliminated. Synchrotron X-ray fluorescence showed Ag in the S-cells of the hepatopancreas, thus supporting the observations from the kinetic experiment (i.e. low elimination). In addition, our results show that isopods have an extremely high Ag accumulation capacity, suggesting the presence of an efficient Ag storage compartment.

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“…For analyzing survival-time relationships in the test solution, a logistic model as explained by Crommentuijn et al [22] was used…”

Section: Discussionmentioning

confidence: 99%

Toxicodynamics of copper and cadmium inFolsomia candidaexposed to simulated soil solutions

Ardestani¹,

Gestel²

2013

Enviro Toxic and Chemistry

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To improve our understanding of metal bioavailability to soil-living invertebrates, the effect of porewater composition on the toxicodynamics of copper and cadmium in Folsomia candida (Collembola) was investigated. Assuming that porewater is the main exposure route, F. candida was exposed to simulated soil solutions of different composition. Toxicity of copper was slightly lower in a calcium-only solution than in a multication solution. With increasing copper concentrations from 0.005 mM to 1.37 mM, internal copper concentrations similarly increased in both exposure solutions, suggesting that a single cation nutrient solution is suitable for testing F. candida. In the second experiment, animals were exposed for 7 d to copper and cadmium in simplified soil solutions with different calcium (0.2 mM, 0.8 mM, 3.2 mM, 12.8 mM) and pH (5.0, 6.0, 7.0) levels. The median lethal concentration (LC50) values decreased with time in both the calcium and pH series. A hormetic-type effect was observed for copper in the second test, as well as in the calcium-only solution in the first experiment. Because of stronger hormesis, LC50s for copper were higher at lower calcium concentrations. For cadmium, LC50 values were higher at higher calcium concentrations, suggesting competition of calcium with the free cadmium ion. Toxicity of cadmium increased with decreasing pH, while copper was more toxic at intermediate pH. The results show that a toxicodynamics approach can help to improve the interpretation of metal toxicity to soil invertebrates, taking into account soil solution properties.

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Lethal Body Concentrations and Accumulation Patterns Determine Time-Dependent Toxicity of Cadmium in Soil Arthropods

Cited by 34 publications

References 0 publications

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>

Toxicokinetics of Ag in the terrestrial isopod Porcellionides pruinosus exposed to Ag NPs and AgNO3 via soil and food

Toxicodynamics of copper and cadmium inFolsomia candidaexposed to simulated soil solutions

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