Lesion of the Basal Ganglia and Surgery for Parkinson Disease

Radiofrequency Ablation: How to Ensure Worldwide Availability of Surgery for Parkinson's Disease

“…26 However, from a pathophysiological perspective, studies have shown that therapeutic lesions can effectively stop faulty signaling in the motor system by halting the execution of learned stimulus-driven responses. 27 This supports the idea that blocking basal ganglia activity is better than allowing faulty signaling to disrupt the motor system. 28 Conversely, DBS has become an efficient and low-risk therapy, even when applied bilaterally in the basal ganglia and thalamic targets.…”

“…Finally, there is an unfounded denigration of ablative surgery in general; this concern or prejudice against ablation concerns treating a condition by performing a lesion 26 . However, from a pathophysiological perspective, studies have shown that therapeutic lesions can effectively stop faulty signaling in the motor system by halting the execution of learned stimulus‐driven responses 27 . This supports the idea that blocking basal ganglia activity is better than allowing faulty signaling to disrupt the motor system 28 …”

Radiofrequency Ablation: How to Ensure Worldwide Availability of Surgery for Parkinson's Disease

“…26 However, from a pathophysiological perspective, studies have shown that therapeutic lesions can effectively stop faulty signaling in the motor system by halting the execution of learned stimulus-driven responses. 27 This supports the idea that blocking basal ganglia activity is better than allowing faulty signaling to disrupt the motor system. 28 Conversely, DBS has become an efficient and low-risk therapy, even when applied bilaterally in the basal ganglia and thalamic targets.…”

“…Finally, there is an unfounded denigration of ablative surgery in general; this concern or prejudice against ablation concerns treating a condition by performing a lesion 26 . However, from a pathophysiological perspective, studies have shown that therapeutic lesions can effectively stop faulty signaling in the motor system by halting the execution of learned stimulus‐driven responses 27 . This supports the idea that blocking basal ganglia activity is better than allowing faulty signaling to disrupt the motor system 28 …”

Neural Circuit Modulation During Deep Brain Stimulation at the Subthalamic Nucleus for Parkinson's Disease: What Have We Learned from Neuroimaging Studies?

“…The GPi represents one of the major output structures of the basal ganglia, along with the substantia nigra pars reticulata, and it provides tonic inhibitory drive to the motor thalamus under normal conditions. Interest in the GPi within the context of Parkinson's disease arises from many sources, including the therapeutic effects exerted from lesioning (pallidotomy) or DBS at this target (Follett and Torres-Russotto, 2012; Obeso et al, 2001; Pizzolato and Mandat, 2012; Rouaud et al, 2010). In classical models of Parkinson's disease, loss of striatal dopamine is predicted to result in hyperactivity within the GPi with consequent over-inhibition of thalamocortical motor relays (Obeso et al, 2008b; Wichmann et al, 2011).…”

Pathological gambling in Parkinson Disease: element diagnosis or consequence of the treatment?

“…Atualmente, sabe-se que esta é uma doença neurodegenerativa e progressiva acometendo o sistema nigroestriatal dopaminérgico 3 , clinicamente caracterizada por distúrbios do movimento, da postura e do equilíbrio, manifestando-se através de acinesia, rigidez, tremor de repouso e instabilidade postural 4 .…”

Radiofrequency Ablation: How to Ensure Worldwide Availability of Surgery for Parkinson's Disease

“…26 However, from a pathophysiological perspective, studies have shown that therapeutic lesions can effectively stop faulty signaling in the motor system by halting the execution of learned stimulus-driven responses. 27 This supports the idea that blocking basal ganglia activity is better than allowing faulty signaling to disrupt the motor system. 28 Conversely, DBS has become an efficient and low-risk therapy, even when applied bilaterally in the basal ganglia and thalamic targets.…”

“…Finally, there is an unfounded denigration of ablative surgery in general; this concern or prejudice against ablation concerns treating a condition by performing a lesion 26 . However, from a pathophysiological perspective, studies have shown that therapeutic lesions can effectively stop faulty signaling in the motor system by halting the execution of learned stimulus‐driven responses 27 . This supports the idea that blocking basal ganglia activity is better than allowing faulty signaling to disrupt the motor system 28 …”

Neural Circuit Modulation During Deep Brain Stimulation at the Subthalamic Nucleus for Parkinson's Disease: What Have We Learned from Neuroimaging Studies?

“…The GPi represents one of the major output structures of the basal ganglia, along with the substantia nigra pars reticulata, and it provides tonic inhibitory drive to the motor thalamus under normal conditions. Interest in the GPi within the context of Parkinson's disease arises from many sources, including the therapeutic effects exerted from lesioning (pallidotomy) or DBS at this target (Follett and Torres-Russotto, 2012; Obeso et al, 2001; Pizzolato and Mandat, 2012; Rouaud et al, 2010). In classical models of Parkinson's disease, loss of striatal dopamine is predicted to result in hyperactivity within the GPi with consequent over-inhibition of thalamocortical motor relays (Obeso et al, 2008b; Wichmann et al, 2011).…”

Pathological gambling in Parkinson Disease: element diagnosis or consequence of the treatment?

“…Atualmente, sabe-se que esta é uma doença neurodegenerativa e progressiva acometendo o sistema nigroestriatal dopaminérgico 3 , clinicamente caracterizada por distúrbios do movimento, da postura e do equilíbrio, manifestando-se através de acinesia, rigidez, tremor de repouso e instabilidade postural 4 .…”

Radiofrequency Ablation: How to Ensure Worldwide Availability of Surgery for Parkinson's Disease

“…26 However, from a pathophysiological perspective, studies have shown that therapeutic lesions can effectively stop faulty signaling in the motor system by halting the execution of learned stimulus-driven responses. 27 This supports the idea that blocking basal ganglia activity is better than allowing faulty signaling to disrupt the motor system. 28 Conversely, DBS has become an efficient and low-risk therapy, even when applied bilaterally in the basal ganglia and thalamic targets.…”

“…Finally, there is an unfounded denigration of ablative surgery in general; this concern or prejudice against ablation concerns treating a condition by performing a lesion 26 . However, from a pathophysiological perspective, studies have shown that therapeutic lesions can effectively stop faulty signaling in the motor system by halting the execution of learned stimulus‐driven responses 27 . This supports the idea that blocking basal ganglia activity is better than allowing faulty signaling to disrupt the motor system 28 …”

Neural Circuit Modulation During Deep Brain Stimulation at the Subthalamic Nucleus for Parkinson's Disease: What Have We Learned from Neuroimaging Studies?

“…The GPi represents one of the major output structures of the basal ganglia, along with the substantia nigra pars reticulata, and it provides tonic inhibitory drive to the motor thalamus under normal conditions. Interest in the GPi within the context of Parkinson's disease arises from many sources, including the therapeutic effects exerted from lesioning (pallidotomy) or DBS at this target (Follett and Torres-Russotto, 2012; Obeso et al, 2001; Pizzolato and Mandat, 2012; Rouaud et al, 2010). In classical models of Parkinson's disease, loss of striatal dopamine is predicted to result in hyperactivity within the GPi with consequent over-inhibition of thalamocortical motor relays (Obeso et al, 2008b; Wichmann et al, 2011).…”

Pathological gambling in Parkinson Disease: element diagnosis or consequence of the treatment?

“…Atualmente, sabe-se que esta é uma doença neurodegenerativa e progressiva acometendo o sistema nigroestriatal dopaminérgico 3 , clinicamente caracterizada por distúrbios do movimento, da postura e do equilíbrio, manifestando-se através de acinesia, rigidez, tremor de repouso e instabilidade postural 4 .…”