2017
DOI: 10.18632/aging.101183
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Exposures to various DNA damaging agents can deregulate a wide array of critical mechanisms that maintain genome integrity. It is unclear how these processes are impacted by one's age at the time of exposure and the complexity of the DNA lesion. To clarify this, we employed radiation as a tool to generate simple and complex lesions in normal primary human mammary epithelial cells derived from women of various ages. We hypothesized that genomic instability in the progeny of older cells exposed to complex damage… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
6
0

Year Published

2019
2019
2019
2019

Publication Types

Select...
1

Relationship

1
0

Authors

Journals

citations
Cited by 2 publications
(6 citation statements)
references
References 59 publications
(65 reference statements)
0
6
0
Order By: Relevance
“…We chose to study centrosome aberrations as our surrogate end point of cancer risk, as it has been well documented that aberrations in centrosome number can disrupt tissue architecture and genomic instability; the two main hallmarks of carcinogenesis (Nigg, 2006;Rivera-Rivera & Saavedra, 2016). We and others have also shown that centrosome defects increase with simple and complex damage (Sato et al, 1983;Sudo et al, 2008, Sridharan et al, 2017 and can sensitively differentiate between radiation and age dependent effects (Sridharan et al, 2017). However, the influence of individual genetics in eliciting centrosome defects with exposure to complex damages is not well-understood.…”
Section: Discussionmentioning
confidence: 99%
See 4 more Smart Citations
“…We chose to study centrosome aberrations as our surrogate end point of cancer risk, as it has been well documented that aberrations in centrosome number can disrupt tissue architecture and genomic instability; the two main hallmarks of carcinogenesis (Nigg, 2006;Rivera-Rivera & Saavedra, 2016). We and others have also shown that centrosome defects increase with simple and complex damage (Sato et al, 1983;Sudo et al, 2008, Sridharan et al, 2017 and can sensitively differentiate between radiation and age dependent effects (Sridharan et al, 2017). However, the influence of individual genetics in eliciting centrosome defects with exposure to complex damages is not well-understood.…”
Section: Discussionmentioning
confidence: 99%
“…We previously showed that complex damages elicit increased centrosome aberrations in an age dependent manner in HMECs (Sridharan et al, 2017). However, this relationship has not been characterized in HMECs derived from individuals with genetic variations.…”
Section: Increased Centrosome Aberrations In Cells With Genetic Variamentioning
confidence: 96%
See 3 more Smart Citations