“…We chose to study centrosome aberrations as our surrogate end point of cancer risk, as it has been well documented that aberrations in centrosome number can disrupt tissue architecture and genomic instability; the two main hallmarks of carcinogenesis (Nigg, 2006;Rivera-Rivera & Saavedra, 2016). We and others have also shown that centrosome defects increase with simple and complex damage (Sato et al, 1983;Sudo et al, 2008, Sridharan et al, 2017 and can sensitively differentiate between radiation and age dependent effects (Sridharan et al, 2017). However, the influence of individual genetics in eliciting centrosome defects with exposure to complex damages is not well-understood.…”