Leptospirosis as an unusual culprit of acute pancreatitis and portal vein thrombosis in a New Yorker

Afzal, Iman; Thaker, Rishi; Weissman, Simcha; Kothari, Megha

doi:10.1002/ccr3.2736

Cited by 4 publications

(2 citation statements)

References 27 publications

(57 reference statements)

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“…6 Since then, several case series have been published in both adults and children. [7][8][9][10][11][12] In 2003, the first study involving 33 patients who died from fatal leptospirosis and submitted for autopsy, found that 12 (36.6%) had pancreatic involvement. 13 Another study in 2013 involving 20 cases found 13 cases of pancreatic damage, including four aspects of fatty necrosis.…”

Section: Discussionmentioning

confidence: 99%

Severe Acute Pancreatitis Associated with Weil’s Disease

Guechi,

Guenifi,

Gasmi

et al. 2023

Middle East J Dig Dis

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Leptospirosis is an emerging zoonosis of worldwide importance. Its distribution is closely linked to hydrometric conditions. It is characterized by a wide clinical range, from the subclinical form, or one with few symptoms; which resolves spontaneously, to the multi-visceral form, known as icterrohemorrhagic disease or Weil’s disease, with a lethal risk. All organs can be affected but with variable frequency. Pancreatic involvement is not well documented. We describe a 45-year-old man with Weil’s disease associated with acute necrotizing pancreatitis. The evolution was favorable but required a three-week stay in the intensive care unit.

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“…Acute renal failure, rhabdomyolysis, and biphasic progression are classic complications of severe leptospirosis [ 11 ], but infection with Leptospira spp. accompanied by PVT has rarely been described [ 12 ]. However, activation of the coagulation system triggering the development and progression of thrombosis can be found in the literature [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Unhappy Triad: Infection with Leptospira spp. Escherichia coli and Bacteroides uniformis Associated with an Unusual Manifestation of Portal Vein Thrombosis

Kalbitz¹,

Ermisch²,

Schmidt³

et al. 2021

Case Rep Gastroenterol

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Portal vein thrombosis (PVT) is a rare disease with an incidence of 0.7/100,000 inhabitants per year. Septic PVT (pylephlebitis) usually occurs secondary to infection in the anatomic region drained by the portal venous system. We report on a 76-year-old German male who was admitted with a history of recurrent fever and acute renal failure. Blood cultures taken on admission showed Escherichia coli, as well as Bacteroides uniformis after an extended incubation period of 90 h. In addition, infection with Leptospira spp. was diagnosed serologically. Computerized tomography of the abdomen revealed an extensive PVT along with signs of colonic diverticulitis. Symptoms resolved under prolonged antimicrobial therapy with beta-lactams and adequate heparinization. A myeloproliferative disorder could be excluded. There was no evidence of an underlying coagulation disorder. Imaging controls showed an almost complete resolution of the PVT after 6 months of anticoagulation therapy. To the best of our knowledge, this is the first report of such an “unhappy triad,” which includes atypical manifestations of leptospirosis and involvement of other intestinal bacteria.

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Leptospirosis as an unusual culprit of acute pancreatitis and portal vein thrombosis in a New Yorker

Cited by 4 publications

References 27 publications

Severe Acute Pancreatitis Associated with Weil’s Disease

Unhappy Triad: Infection with <b><i>Leptospira</i></b> spp. <b><i>Escherichia coli</i></b> and <b><i>Bacteroides uniformis</i></b> Associated with an Unusual Manifestation of Portal Vein Thrombosis

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