volume 24, issue s2, P17-25 2011
DOI: 10.3233/jad-2011-102070
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Rocío Pérez-González, Desiree Antequera, Teo Vargas, Carlos Spuch, Marta Bolós, Eva Carro

Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with senile amyloid-β (Aβ) plaques, neuronal death, and cognitive decline. Neurogenesis in the adult hippocampus, which is notably affected by progressive neurodegeneration and Aβ pathology, is implicated in learning and memory regulation. Human postmortem brains of AD patients and AβPP/PS1 double transgenic mice show increased neurodegeneration. Leptin, an adipose-derived hormone, promotes neurogenesis in the adult hippocampus, but…

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