Leptin as a predictive marker for metabolic syndrome

Ghadge, Abhijit A.; Khaire, Amrita

doi:10.1016/j.cyto.2019.154735

Cited by 115 publications

(87 citation statements)

References 84 publications

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“…The current study demonstrated that serum concentrations of leptin and adiponectin were positively and negatively correlated with body fat mass, respectively. This finding is in agreement with previous reports of high serum leptin levels and low serum adiponectin levels in obese patients 1,2,14 . Because both leptin and adiponectin are primarily produced in adipose tissue, it is not surprising that serum leptin concentrations correlated positively with the amount of body fat.…”

Section: Discussionsupporting

confidence: 94%

“…The factor that hampers such analyses might be the great influence of body fat mass because both of these adipocytokines are produced mainly by adipocytes. Serum concentration of leptin increases as body fat mass increases 1 , whereas serum adiponectin concentration paradoxically decreases as body fat mass increases probably because of the suppressive effect TNF-α on adiponectin production 2,14 . Body mass index (BMI), body weight normalized by height squared (kg/m 2 ), is a very simple and inexpensive method to estimate body fat.…”

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confidence: 99%

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Re-evaluation of serum leptin and adiponectin concentrations normalized by body fat mass in patients with rheumatoid arthritis

Chihara

Hattori

Ichikawa

et al. 2020

Sci Rep

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Leptin and adiponectin are produced mainly in adipocytes and classified as adipocytokines because of their possible involvement in inflammation and immunity. The aim of this study was to elucidate the relationships of these adipocytokines with the disease activities of RA. We examined leptin and adiponectin concentrations and inflammatory markers such as metalloproteinase-3 (MMP-3) in 136 patients with rheumatoid arthritis (RA) (26 males and 110 females, 69.6 ± 9.3 years) and 78 controls (36 males and 42 females, 66.7 ± 15.0 years). Serum leptin and adiponectin concentrations correlated positively (r = 0.565, P < 0.001) and negatively (r = –0.331, P < 0.001) to the amount of body fat, respectively. Serum leptin and adiponectin concentrations normalized by body fat mass were significantly higher in RA than those in controls [leptin, 1.24 (median) ng/mL/kg fat in RA vs. 0.76 ng/mL/kg fat in controls; adiponectin, 0.74 μg/mL/kg fat in RA vs. 0.44 μg/mL/kg fat in controls]. Normalized adiponectin concentrations correlated positively not only to the degree of bone destruction in Steinbrocker classification but also to serum MMP-3 concentrations. Normalized leptin concentrations did not correlate to the degree of bone destruction. We conclude that adiponectin but not leptin may be involved in joint damage in RA.

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Section: Discussionsupporting

confidence: 94%

mentioning

confidence: 99%

Re-evaluation of serum leptin and adiponectin concentrations normalized by body fat mass in patients with rheumatoid arthritis

Chihara

Hattori

Ichikawa

et al. 2020

Sci Rep

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“…Leptin is involved in the regulation of food intake, body weight, energy homeostasis, insulin sensitivity, and lipid metabolism. Leptin has been implicated in the pathogenesis of MetS [ 72 ], with high levels of leptin associated with the upregulation of pro-inflammatory cytokines, obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. In both pulp [ 73 ] and periapical infections [ 74 ] as well as periodontal disease [ 23 ], leptin levels are increased.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Apical Periodontitis and Metabolic Syndrome and Cardiovascular Events: A Cross-Sectional Study

González-Navarro

Segura-Egea

Estrugo‐Devesa

et al. 2020

JCM

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Aim: Both apical periodontitis (AP) and metabolic syndrome (MetS) are associated with atherosclerotic cardiovascular disease (ACVD), the main cause of cardiovascular events. The aim of this study was to investigate the prevalence of AP and the oral inflammatory burden in control subjects and patients suffering cardiovascular events, analyzing the possible association between AP and the oral inflammatory burden with MetS. Materials and Methods: Using a cross-sectional design, 83 patients suffering a cardiovascular event were recruited in the study group (SG), and 48 patients without cardiovascular events were included in the control group (CG). Periapical index (PAI) was used to diagnose AP, and total dental index (TDI) was used to assess the total oral inflammatory burden. Diagnosis of MetS was made by meeting three or more American Heart Association Scientific Statement components. Results: In the multivariate logistic regression analysis, the number of teeth with AP (OR = 2.3; 95% C.I. = 1.3–4.3; p = 0.006) and TDI scores (OR = 1.5; 95% C.I. = 1.2–1.9; p = 0.001), significantly correlated with cardiovascular events. MetS was strongly associated (OR = 18.0; 95% C.I. = 6.5–49.7; p = 0000) with cardiovascular events. Higher TDI scores were significantly associated with MetS (OR = 1.3; 95% C.I. = 1.1–1.6; p = 0.003. Neither the number of root-filled teeth (RFT) (OR = 0.9; 95% C.I. = 0.6–1.3; p = 0.61) nor the number of teeth with apical periodontitis (OR = 1.1; 95% C.I. = 0.8–1.7; p = 0.49) were associated with MetS. Conclusions: Apical periodontitis is significantly associated with cardiovascular events. Total oral inflammatory burden assessed by TDI, but not AP alone, is associated with MetS.

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“…Adiponectin and leptin, the most prevalent adipo-cytokines, produced in adipose tissue, play critical metabolic and anti-inflammatory roles through adipose tissue crosstalk. [81][82][83] Low adiponectin and high leptin correlate with many metabolic diseases including T2D, MS, and obesity [82][83][84][85][86][87] and are considered as predictive clinical markers. While some studies showed HIIT does not affect adiponectin 53,56,88 or leptin, 58,89 others report increased adiponectin 41,45,55,67 and decreased leptin.…”

Section: Quality Assessment and Publication Biasmentioning

confidence: 99%

The impact of high‐intensity interval training on inflammatory markers in metabolic disorders: A meta‐analysis

Khalafi

Symonds

2020

Scandinavian Med Sci Sports

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Chronic, low-grade systematic inflammation contributes to the pathogenesis of many metabolic disorders, 1 which are usually accompanied with excess adiposity. Adipose tissue is a large metabolic organ that regulates inflammatory responses due to the secretion of pro-and anti-inflammatory cytokines. 2 These can then contribute to the onset of insulin resistance 3-6 and cardiovascular disease (CVD). 7,8 An imbalanced ratio of pro-and anti-inflammatory cytokines/adipokines with excess fat mass 9 is prevalent with the metabolic syndrome (MS), 10 type 1 (T1D), 11 and 2 diabetes (T2D), 12 polycystic ovary syndrome (PCOS), 13,14 and non-alcoholic fatty liver disease (NAFLD). 15 Cytokines are

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Leptin as a predictive marker for metabolic syndrome

Cited by 115 publications

References 84 publications

Re-evaluation of serum leptin and adiponectin concentrations normalized by body fat mass in patients with rheumatoid arthritis

Re-evaluation of serum leptin and adiponectin concentrations normalized by body fat mass in patients with rheumatoid arthritis

Relationship between Apical Periodontitis and Metabolic Syndrome and Cardiovascular Events: A Cross-Sectional Study

The impact of high‐intensity interval training on inflammatory markers in metabolic disorders: A meta‐analysis

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