Leptin and cardiometabolic risk factors in obese children and adolescents

Gonzaga, Nathalia Costa; Medeiros, Carla Campos Muniz; Carvalho, Danielle F. de; Alves, João Guilherme Bezerra

doi:10.1111/jpc.12610

Cited by 26 publications

(20 citation statements)

References 25 publications

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“…Several previous studies have concluded that the relationship between serum leptin and lipid (cholesterol and triglycerides) concentrations was not statistically significant when adjusted for variations in age and body mass index . By contrast, in other studies, leptin was reported to be positively correlated with cholesterol in healthy dogs and with triglycerides . In addition, leptin was found to play a role in the decrease in very‐low‐density lipoprotein triglyceride after weight loss .…”

Section: Discussionmentioning

confidence: 82%

Increased Leptin and Leptin Receptor Expression in Dogs With Gallbladder Mucocele

Lee

Kweon

Kim

2016

Veterinary Internal Medicne

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BackgroundLeptin and its receptor play a role in several disease processes such as pancreatitis and heart disease. However, their association with gallbladder mucocele (GBM) in dogs has not been reported.Hypothesis/ObjectivesTo evaluate differences in the expression of leptin and leptin receptor between dogs with and without GBM.AnimalsTwenty‐five healthy dogs, including 9 laboratory beagle dogs, and 22 client‐owned dogs with GBM.MethodsSerum leptin concentration was determined in blood samples of all dogs by ELISA. Canine gallbladder samples were collected from 9 dogs with GBM that underwent surgery for therapeutic purposes and from 9 healthy laboratory beagle dogs as a normal control group. Samples were analyzed for leptin and leptin receptor mRNA by real‐time polymerase chain reaction.ResultsSerum leptin concentration was significantly higher in dogs with GBM than in healthy dogs (medians of 7.03 and 2.18 ng/mL, respectively; P < .001). Patients with GBM that had undergone surgery had significantly higher serum leptin concentrations than those that had not (medians of 12.2 and 4.09 ng/mL, respectively; P = .001). However, no difference in serum leptin concentration was found between dogs with GBM with or without endocrinopathies. The mRNA expression levels of leptin and its receptor were significantly increased in the gallbladder tissues of dogs with GBM.Conclusions and Clinical ImportanceDysregulation of leptin might be involved in the pathophysiology of GBM, and leptin concentrations might be associated with GBM severity.

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Section: Discussionmentioning

confidence: 82%

Increased Leptin and Leptin Receptor Expression in Dogs With Gallbladder Mucocele

Lee

Kweon

Kim

2016

Veterinary Internal Medicne

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“…Our results showed that increased leptin levels may be associated with insulin resistance because leptin levels were positively correlated with fasting serum insulin levels and HOMA‐IR index and negatively with QUICKI. In the Brazilian study, higher leptin levels were positively correlated with insulin resistance (HOMA‐IR index) in children and adolescents (Gonzaga, Medeiros, de Carvalho, & Alves, ). In addition, the fasting leptin level is negatively associated with insulin sensitivity in women with a previous history of gestational diabetes mellitus (Madarász et al, ).…”

Section: Discussionmentioning

confidence: 96%

Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women

Duan

Jhang

et al. 2020

Molec Gen & Gen Med

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Background Obesity has become the main health issue in developed countries as it impacts life expectancy and increases mortality of cerebrovascular or cardiovascular diseases. The leptin is one of the adipokines which presents in the serum in proportion to the amount of adipose tissue and is translated from LEP gene. It involves in energy homeostasis, lipid and glucose metabolisms, modulation of immune systems, and thermogenesis. Many previous studies have revealed controversial results between LEP polymorphisms and leptin levels in different ages and ethnicities. Herein, we investigated the impacts of LEP polymorphism against leptin levels in Taiwanese subjects. Methods In 599 Taiwanese subjects, excluding clinically overt systemic disease, age below 18 years old, and C‐reactive protein (CRP) level of above 10 mg/L, few of LEP polymorphisms were genotyped with TaqMan SNP genotyping assays, were further analyzed for association with leptin level in univariate and multivariate linear regression analyses with Bonferroni correction for multiple tests in stratified groups. The univariate and stepwise multivariate linear regression analyses were performed to determine the coefficient of determinant of LEP polymorphisms over leptin level. Results Significant associations were found between LEP polymorphisms and leptin levels in obese women. Circulating leptin level was positively correlated with inflammatory, insulin resistance markers, and visceral obesity markers in all subjects. Furthermore, stratified and interaction analyses revealed that LEP polymorphisms, rs7799039 and rs2167270, were significantly associated with leptin levels in obese women—8%–10% of which could be explained by LEP polymorphisms. Conclusion The LEP polymorphisms are independently associated with leptin levels in Taiwanese obese women. Further, the genetic determinants for leptin levels may be different between obese and nonobese, and in different sex individuals. The obesity status and female sex may exert modification effect on transcription of LEP, particularly in obese women.

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“…Increased leptin levels were associated with elevated uric acid levels (de Oliveira and Burini, 2012), and leptin might be a useful marker of the metabolic syndrome in adolescents (Gonzaga et al, 2014). The present study found that serum uric acid levels linearly increased with increased serum leptin levels, which is consistent with the previous report (Fruehwald-Schultes et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Hyperuricemia in Children and Adolescents with Autism Spectrum Disorder Treated with Risperidone: The Risk Factors for Metabolic Adverse Effects

et al. 2017

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Background: Atypical antipsychotics have been found to be associated with hyperuricemia. Risperidone, one of the atypical antipsychotics, might be related to the hyperuricemia among autism spectrum disorder (ASD) patients. The aims of this study were to determine the prevalence of hyperuricemia in ASD patients treated with risperidone and to determine associations between serum uric acid levels and risperidone dosage, treatment duration, and metabolic parameters.Methods: 127 children and adolescents with ASD treated with risperidone and 76 age-matched risperidone-naïve patients with ASD were recruited. The clinical data and laboratory data were analyzed. Hyperuricemia was defined as serum uric acid >5.5 mg/dl.Results: Hyperuricemia was present in 44.70% of risperidone-naïve patients with ASD and 57.50% of ASD patients treated with risperidone. The fasting uric acid levels were significantly higher in the risperidone group than in the risperidone-naïve group (5.70 vs. 5.35 mg/dl, P = 0.01). The increased uric acid concentrations were significantly associated with adolescent patients treated with risperidone. The higher dose of risperidone and/or the longer treatment time were associated with the increased uric acid levels. Uric acid levels significantly rose with body mass index (BMI), waist circumference (WC), triglyceride (TG) levels, triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C), insulin levels, homeostatic model assessment index (HOMA-IR), high-sensitivity CRP (hs-CRP) levels, and leptin levels. Conversely, the levels of HDL-C and adiponectin were negatively correlated with uric acid levels. In multiple regression analysis, there were age, BMI, TG/HDL-C ratio, and adiponectin levels remained significantly associated with uric acid levels.Conclusion: Hyperuricemia may play a role in metabolic adverse effect in children and adolescents with ASDs receiving the high dose and/or the long-term treatment with risperidone.

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Leptin and cardiometabolic risk factors in obese children and adolescents

Abstract: Leptin may be a useful marker of metabolic syndrome and insulin resistance in obese adolescents.

Cited by 26 publications

References 25 publications

Increased Leptin and Leptin Receptor Expression in Dogs With Gallbladder Mucocele

Increased Leptin and Leptin Receptor Expression in Dogs With Gallbladder Mucocele

Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women

Hyperuricemia in Children and Adolescents with Autism Spectrum Disorder Treated with Risperidone: The Risk Factors for Metabolic Adverse Effects

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