Leprosy of the larynx

Soni, N. K.

doi:10.1017/s002221510012002x

Cited by 25 publications

(21 citation statements)

References 3 publications

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“…Some authors such as Motta et al(6), Soni (18) and Palaskar (19) established that the oral lesions usually appear in the advanced stage of leprosy.…”

Section: Discussionmentioning

confidence: 99%

Oro-facial manifestations of 100 leprosy patients

Taheri¹,

Mortazavi²,

Moshfeghi³

et al. 2012

Med Oral

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Objectives: To verify the frequency of oral and facial involvement in diagnosed leprosy patients. Study design: This study was performed on 100 leprosy patients (62 male, 38 female, mean ages 51.86±6.1). After explaining the study design, we studied descriptive information including: patient’s sex, age, job, place of birth, familial history of leprosy, types of disease (lepromatous, borderline and tuberculoid leprosy), ocular and oral lesions, facial involvement and neuropathy. The statistical signification was measured by chi-square test. Results: A total of 46 (23 lepromatous, 15 borderline, and 8 tuberculoid leproy) out of 100 patients with leprosy had oral lesions. Statistical analysis did not show any significant difference in frequency of oral lesions between different types of disease. Facial lesions were presented in 57 (39 lepromatous, 10 borderline, and 8 tuberculoid leprosy) patients. There was a statistical significant difference in frequency of facial manifestations between different types of leprosy. It has to be mentioned that, atrophy of nasal spine, facial nerve involvement, ocular lesions and facial deformity were seen in 15%, 17%, 22% and 44% of leprosy patients, respectively. Conclusion: Examination of leprosy patients should be extended to the oral mucosa because oral mucosa may be a secondary source of M.Leprae transmission and infection. Key words:Leprosy, lepromatous, tuberculoid, oral lesions, facial lesions.

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“…Some authors such as Motta et al(6), Soni (18) and Palaskar (19) established that the oral lesions usually appear in the advanced stage of leprosy.…”

Section: Discussionmentioning

confidence: 99%

Oro-facial manifestations of 100 leprosy patients

Taheri¹,

Mortazavi²,

Moshfeghi³

et al. 2012

Med Oral

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“…These lesions should be biopsied and analyzed histopathologically; the association of acid-alcohol resistant bacilli and a 8,9 . Few authors did histopathological examination of detected lesions 10,12,13,16 .This may be one of the explanations for the disagreement in frequency rates of oral involvement in leprosy seen in literature, which varies from absent up to 57.5% [4][5][6][7][8][9][10][11] . The decision to biopsy three areas was to increase the positive result rate.…”

Section: Discussionmentioning

confidence: 99%

“…The oral cavity may be contaminated by bacilli present in rhinopharyngeal secretions, however, notwithstanding this contamination, oral cavity is resistant to lesions. These are almost only restricted to multibacillar patients in advanced stages of disease [4][5][6][7][8][9][10][11] , which suggests that bacillary invasion of the oral cavity results from bacillemia from bacterial dissemination and multiplication 12,13 . However, the oral cavity with no evident injuries may be affected in less advanced stages of the disease.…”

Section: Introductionmentioning

confidence: 99%

A mucosa oral na hanseníase: um estudo clínico e histopatológico

Abreu

Michalany

Weckx

et al. 2006

Rev. Bras. Otorrinolaringol.

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INTRODUÇÃO: a anseníase multibacilar pode causar comprometimento da mucosa oral, com ou sem lesões aparentes. Há poucos estudos que tratam deste assunto na era da multidrogaterapia. OBJETIVO: Verificar a freqüência do comprometimento da mucosa oral em pacientes de hanseníase multibacilar. CASUÍSTICA E MÉTODOS: Foi realizado um estudo transversal em vinte pacientes de hanseníase multibacilar, não-tratados, atendidos consecutivamente em Dracena, São Paulo, entre o período de 2000 e 2002. Foi realizado exame clínico completo da mucosa oral. Os pacientes foram submetidos a biópsias na mucosa jugal, na língua e no palato mole, em alteração ou em pontos pré-estabelecidos. Os cortes foram corados pelas técnicas da hematoxilina-eosina e Ziehl-Neelsen. O encontro de granuloma e bacilos álcool-ácido-resistentes ao exame histopatológico determinou o comprometimento específico. RESULTADOS: O estudo envolveu 19 pacientes multibacilares com tempo médio de evolução de 2,5 anos. Ocorreu comprometimento histopatológico específico em apenas um paciente virchowiano, com mucosa oral clinicamente normal, na língua e no palato mole. CONCLUSÕES: 1. Alteração clínica na mucosa oral não implica em comprometimento pela doença, é necessário confirmação histopatológica. 2. Alterações clínicas específicas aparentes são raras. 3. A mucosa oral clinicamente normal pode exibir comprometimento histopatológico específico.

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“…Laryngeal involvement is a well‐known feature of advanced leprosy, although with the use of multidrug therapy there has been a decline in its occurrence. Surveys in the past found laryngeal involvement at the time of presentation in 40–50% of leprosy patients 34,39,40 …”

Section: Otorhinolaryngologic Involvement (Table 1)mentioning

confidence: 99%