1994
DOI: 10.1001/archderm.130.8.1008
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Lentigo maligna of the head and neck. Results of treatment by radiotherapy

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Cited by 50 publications
(67 citation statements)
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“…Third, surgical excision does not result in the pigmentary changes sometimes seen in destructive modalities such as radiotherapy and cryotherapy; these pigmentary changes may also make subsequent recurrence difficult to detect. 8,36 In conclusion, the current recommendations of 5-mm margins for in situ melanoma (LM) and 10-mm margins for melanoma less than 1 mm in Breslow thickness are sufficient for only 80% of primary LMs larger than 10 mm and 90% of primary LMMs larger than 10 mm and less than 1 mm in Breslow thickness. These guidelines may, however, be useful initial margins for the technique of MSE.…”
Section: Number Of 5-mm Levels For Complete Excision Of Primary and Rmentioning
confidence: 95%
“…Third, surgical excision does not result in the pigmentary changes sometimes seen in destructive modalities such as radiotherapy and cryotherapy; these pigmentary changes may also make subsequent recurrence difficult to detect. 8,36 In conclusion, the current recommendations of 5-mm margins for in situ melanoma (LM) and 10-mm margins for melanoma less than 1 mm in Breslow thickness are sufficient for only 80% of primary LMs larger than 10 mm and 90% of primary LMMs larger than 10 mm and less than 1 mm in Breslow thickness. These guidelines may, however, be useful initial margins for the technique of MSE.…”
Section: Number Of 5-mm Levels For Complete Excision Of Primary and Rmentioning
confidence: 95%
“…Destructive methods are those which destroy the tumor in situ, and as a consequence do not provide a specimen for subsequent analysis by the pathologist. These methods carry recurrence rates of 3-14% [2,3] for radiotherapy, 7-10% for cryosurgery [4], 22% for azelaic acid, 27% for electrodessication and curettage, and 100% for 5-fluorouracil [5]. High recurrence rates are likely related to inadequate treatment of deep periadnexal tumor cells, or those beyond the clinical margin of the lesion.…”
Section: Introductionmentioning
confidence: 99%
“…Multifractionated regimens using a minimum 7-10 mm margins result in good cosmetic result with recurrence rates of 7% [72][73][74][75]. European centers report treatment with very low energy X-rays (12-50 kV) while studies from North America generally used slightly higher energies (100-175 kV).…”
Section: Radiotherapymentioning
confidence: 99%