1963
DOI: 10.1002/jez.1401540105
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Abstract: Developmental problems relating to the stability of cell phenotype, and to the interactions between cells during morphogenesis can be approached particularly well through the study of regenerating systems. In the case of lens regeneration the anatomy of the eye is such that it is possible to identify the tissue types that can form lens, and to analyze the role of the factors which control the regenerative process. At present, it has been established that the lens can regenerate from the iris (Stone, '59; Reye… Show more

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Cited by 147 publications
(165 citation statements)
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“…The best-studied example of lens regeneration occurs in adult newts, where the new lens is formed from pigmented dorsal iris epithelial cells by a process known as Wolffian regeneration (for review see Tsonis, 2006). In 1963, Freeman described a different mechanism in Xenopus laevis tadpoles, whereby regeneration of the lens is from cells of the overlying outer cornea (Freeman, 1963). In lentectomized premetamorphic X. laevis tadpoles, new lens cells transdifferentiate from the cells of the central region of the inner layer of the outer cornea in response to a factor present in the vitreous of the eye (Reeve and Wild, 1981;Filoni et al, 1982).…”
Section: Lens Regenerationmentioning
confidence: 99%
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“…The best-studied example of lens regeneration occurs in adult newts, where the new lens is formed from pigmented dorsal iris epithelial cells by a process known as Wolffian regeneration (for review see Tsonis, 2006). In 1963, Freeman described a different mechanism in Xenopus laevis tadpoles, whereby regeneration of the lens is from cells of the overlying outer cornea (Freeman, 1963). In lentectomized premetamorphic X. laevis tadpoles, new lens cells transdifferentiate from the cells of the central region of the inner layer of the outer cornea in response to a factor present in the vitreous of the eye (Reeve and Wild, 1981;Filoni et al, 1982).…”
Section: Lens Regenerationmentioning
confidence: 99%
“…This as yet unidentified factor is thought to originate from the neural retina . This factor, henceforth described as the vitreous factor, can induce lens differentiation in cells from either the outer cornea or the surrounding pericorneal epidermis, which together form a region termed the lentogenic area that covers an area approximately twice the diameter of the eye (Freeman, 1963). Pieces of either outer cornea or pericorneal epidermis from within the lentogenic area can transdifferentiate into lens tissue when they are transplanted into the vitreous chamber of the eye, where they are exposed to the vitreous factor (Reeve and Wild, 1978;Bosco et al, 1980).…”
Section: Lens Regenerationmentioning
confidence: 99%
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“…In cornea-lens transdifferentiation, a new lens forms from the outer corneal epithelium when the original lens is removed from the eye of a premetamorphosed tadpole (Freeman, 1963). This process is triggered by factors present in the eyecup, which appear to be manufactured by the neural retina (Freeman, 1963;Henry and Mittleman, 1995;Bosco et al, 1997).…”
Section: Introductionmentioning
confidence: 99%