Leiomyoma cutis: A clinicopathological series of 37 cases

Abstract

Background:Cutaneous leiomyomas are benign smooth muscle tumors that comprise three distinct types such as piloleimyoma, angioleiomyoma, and genital leiomyoma.Aim:The objective of this study was to report a series of cases seen in last 8 years in a tertiary care hospital in north India and to discuss their clinicopathologic findings.Material and Methods:Paraffin-embedded blocks of cases reported as cutaneous leiomyoma from 1999 to 2007 were retrieved from the Institute of Pathology, New Delhi, and their clinical parameters were noted. Their histopathological features were reviewed on hematoxylin-eosin stained slides. Immunohistochemistry was performed where necessary.Results:Twenty-seven cases of piloleiomyoma, three cases of angioleiomyoma, five breast leiomyomas, and two scrotal leiomyomas were seen in patients ranging from 21 to 65 years of age, with an average of 38.2 years at presentation. There was a male predominance with 26 males and 11 females (M:F = 2.2:1). Solitary lesions (n = 21) were more common than multiple ( n = 16). The trunk and upper limbs were involved most commonly, comprising 23 of 37 (62.2%) cases. This was followed by lower limb, face, breast, and scrotum.Conclusion:Cutaneous leiomyomas are rare lesions and form an important clinical differential diagnosis of painful papulonodules. These must be biopsied in order to differentiate them from other spindle cell lesions.

A Case of Acral Cutaneous Leiomyoma

“…Angioleiomyomas originate from the tunica media of the small and medium sized arteries. It is observed between the ages 20 to 60 years [5]. The usual localization of this tumour is the lower extremities for females, and the upper extremities for males [1].…”

“…It is seen between the ages 20 and 40. The usual localization is extremities and trunk [4,5]. Piloleiomyomas usually present with pain [6].…”

A generalized multiple cutaneous piloleiomyomatosis in a young male: Rare case report

“…Piloleiomyoma, angioleiomyoma, and genital leiomyoma are the 3 distinct types of cutaneous leiomyomas described. [7] Piloleiomyomas are common in the age group of 10-30 years. [3] They may be solitary or multiple and present as skin-colored to erythematous papulonodules over the extensor surface of the extremities, trunk, face, and neck.…”

Cutaneous leiomyoma in a child: A case report

“…The diagnosis of cutaneous leiomyomas may be accomplished by microscopic examination of a hematoxylin and eosin-stained biopsy of the papule or nodule (10). Tumors in each classification have distinct clinical and/or histologic characteristics (4). Pilar leiomyomas are non-capsulated, circumscribed dermal tumors composed of numerous fascicles of smooth muscle in an interlacing and whorled arrangement (9).…”

“…Cutaneous leiomyomas are rare benign tumors arising from the arrector pili muscle of hair follicles, ranging in number from a few to several hundred (2,3). The skin is the second most common location for leiomyoma after the uterus, hosting ∼5% of all leiomyomas (4). According to their site of origin, leiomyomas may be classified into three types: i) piloleiomyomas, ii) angioleiomyomas and iii) dartoic leiomyomas.…”