Left ventricular perfusion deficit in patients with cystic fibrosis

Exercise-induced hypoxemia and cardiac arrhythmia in cystic fibrosis

“…There is, however, evidence for cardiac involvement with manifestation during exercise in CF. De Wolf et al [16] studied left ventricular perfusion during exercise in 18 patients with CF. Among these, six showed defects in perfusion.…”

“…Further reports indicate fibrotic changes in the myocardium of patients with CF [17,18]. Anyhow, neither De Wolf et al [16] nor any of the other studies we could find report on arrhythmias during exercise in CF. Despite this missing evidence, we hypothesized that exercise-induced cardiac dysrhythmia does occur in patients with CF and that exercise-induced hypoxemia would be a risk factor.…”

What the future holds: cystic fibrosis and aging

“…Many studies did not describe left ventricular dysfunction, though there is some evidence that it might be present during exercise in the pediatric CF population, which seemed to be associated with lung disease severity ( 27 ). Interestingly, there are several case reports describing coronary artery disease in pwCF and possible atherosclerosis ( 28 – 30 ).…”

The relationships between upper extremity muscle strength and endurance with respiratory function, functional capacity and quality of life in children and adolescents with cystic fibrosis

“…Oxygen delivery can be impaired in cystic fibrosis because of various factors, including hypoxemia, impaired cardiac output and perfusion (De Wolf et al, 1998), which occur as a result of decreased physical activity and respiratory problems (Burtin and Hebestreit,…”