Left ventricular geometric patterns in the Jackson cohort of the atherosclerotic risk in communities (ARIC) study: Clinical correlates and influences on systolic and diastolic dysfunction

The Natural History of Left Ventricular Geometry in the Community

“…Among participants with abnormal LV geometry at baseline, those who were female, younger, with lower systolic BP and BMI at baseline were more likely to revert to a normal LV pattern upon follow-up (Supplemental Table 3). These observations are in excellent agreement with data from cross-sectional and longitudinal studies on population-based samples (6,15,24–26). Overall, these data emphasize the importance of controlling CVD risk factors to prevent worsening of LV geometry and to reduce the associated risk of CVD.…”

“…Different LV geometric patterns can be distinguished based on whether RWT and/or LVM are normal versus increased: normal geometry (LVM and RWT are normal), concentric remodeling (increased RWT but normal LVM), concentric hypertrophy (LVM and RWT are increased) and eccentric hypertrophy (increased LVM with normal RWT) (2). Both, increased LVM (3–4) and abnormal LV geometry patterns (5) adversely affect prognosis and are associated with impaired cardiac systolic and diastolic dysfunction (6) as well as with increased risk of CVD events and all-cause mortality prospectively (5,7–10). …”

Left atrial compensatory function in subjects with early stage primary hypertension assessed by using left atrial volumetric emptying fraction acquired by transthoracic echocardiography

“…In subjects with HT, it is generally recognized that firstly LV myocardial hypertrophy occurs, followed by diastolic dysfunction of the LV myocardium and finally systolic dysfunction of the LV myocardium [21][22][23][24][25][26][27][28]. The thickness of IVS, PW of LV and weight of the LV myocardium were significantly larger in subjects with primary HT in this study, in comparison with the control group, but the degree of thickness of IVS, PW of LV and weight of LV myocardium in the primary HT group did not fit the classical criteria of LV hypertrophy.…”

Padrão de remodelação e função ventricular em ratos expostos à fumaça do cigarro

“…Eccentric hypertrophy was associated to a systolic dysfunction, while concentric hypertrophy was associated to diastolic dysfunction. On the other hand, concentric remodeling was not associated to ventricular dysfunction 18 . In the MESA study, however, patients with concentric remodeling presented systolic dysfunction, assessed by means of magnetic resonance 19 .…”