Left ventricular filling pressure in male patients with type 2 diabetes and normal versus low total testosterone levels

Tinetti, Matías; Gysel, Michael; Farias, Javier; Ferrer, Mariano; Lombardero, Martín; Baranchuk, Adrián

doi:10.5603/cj.a2014.0056

Cited by 7 publications

(2 citation statements)

References 31 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cohort clinical study demonstrated that the prevalence of cardiovascular morbidity and mortality increased in patients suffering from prostate cancer (PCa) who have undergone to androgen deprivation therapy (ADT), suggesting that testosterone deficiency was the risk factor of cardiovascular diseases (Gandaglia et al 2015). Moreover, diastolic dysfunction was found in patients with type 2 diabetes with low testosterone level compared with similar patients with normal testosterone levels (Tinetti et al 2015). Furthermore, patients suffering from congestive heart failure (Jankowska et al 2006) and coronary artery disease (Li et al 2012) have been shown to have lower levels of testosterone compared with healthy men, and the severity of these conditions had a strong correlation with the degree of testosterone deficiency (Li et al 2012, Oskui et al 2013.…”

Section: Metabolic Disturbancementioning

confidence: 99%

Testosterone deprivation accelerates cardiac dysfunction in obese male rats

Pongkan

Pintana

Sivasinprasasn

et al. 2016

Journal of Endocrinology

View full text Add to dashboard Cite

Low testosterone level is associated with increased risks of cardiovascular diseases. As obese-insulin-resistant condition could impair cardiac function and that the incidence of obesity is increased in aging men, a condition of testosterone deprivation could aggravate the cardiac dysfunction in obese-insulin-resistant subjects. However, the mechanism underlying this adverse effect is unclear. This study investigated the effects of obesity on metabolic parameters, heart rate variability (HRV), left ventricular (LV) function, and cardiac mitochondrial function in testosterone-deprived rats. Orchiectomized or sham-operated male Wistar rats (n=36per group) were randomly divided into groups and were given either a normal diet (ND, 19.77% of energy fat) or a high-fat diet (HFD, 57.60% of energy fat) for 12weeks. Metabolic parameters, HRV, LV function, and cardiac mitochondrial function were determined at 4, 8, and 12weeks after starting each feeding program. We found that insulin resistance was observed after 8weeks of the consumption of a HFD in both sham (HFS) and orchiectomized (HFO) rats. Neither the ND sham (NDS) group nor ND orchiectomized (NDO) rats developed insulin resistance. The development of depressed HRV, LV contractile dysfunction, and increased cardiac mitochondrial reactive oxygen species production was observed earlier in orchiectomized (NDO and HFO) rats at week 4, whereas HFS rats exhibited these impairments later at week 8. These findings suggest that testosterone deprivation accelerates the impairment of cardiac autonomic regulation and LV function via increased oxidative stress and impaired cardiac mitochondrial function in obese-orchiectomized male rats.

show abstract

Section: Metabolic Disturbancementioning

confidence: 99%

Testosterone deprivation accelerates cardiac dysfunction in obese male rats

Pongkan

Pintana

Sivasinprasasn

et al. 2016

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…A study in men with acute heart failure reported that low circulating T level was related to worse LV diastolic dysfunction 25 . Similarly, another study in men with asymptomatic type 2 diabetes 26 or with type 2 diabetes without structural heart diseases also found that low T was related to the increased LV filling pressure represented by higher E/e’. On the other hand, some studies have suggested T supplementation after myocardial infarction may worsen the patients’ symptoms 27 – 29 , and Culic et al postulated that T was beneficial only for relatively normal hearts 30 .…”

Section: Discussionmentioning

confidence: 79%

The relationship between serum sex hormone and cardiac echocardiographic findings in healthy men

Yeo

Park

Lee

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Serum sex hormones are known to be associated with cardiovascular disease (CVD), but effects in healthy men on cardiac function have not been well quantified. The authors sought to evaluate an association of sex hormones with cardiac structure and function. Study participants were 857 Korean men without significant cardiovascular diseases participating in the Healthy Twin Study. We estimated the associations of total testosterone (TT) and sex hormone-binding globulin (SHBG) with cardiac structure and function measured by echocardiography using a linear mixed regression model with consideration of random and fixed effects of covariates. The ratio of peak early diastolic velocity of mitral inflow over peak early diastolic mitral annular velocity (E/e’) and left atrial volume index (LAVI), functional parameters reflecting left ventricle (LV) filling pressure, were inversely associated with TT even after further cross-adjustment for SHBG level. There was a positive association between LAVI and SHBG, regardless of TT adjustment. These findings suggest that serum testosterone level is positively associated with LV diastolic function independent of SHBG level.

show abstract

Sex hormones and heart failure. Letter regarding the article ‘Pre‐diagnostic free androgen and estradiol levels influence heart failure risk in both women and men: A prospective cohort study in the UK Biobank’

Čulić

2024

European J of Heart Fail

View full text Add to dashboard Cite

Left ventricular filling pressure in male patients with type 2 diabetes and normal versus low total testosterone levels

Cited by 7 publications

References 31 publications

Testosterone deprivation accelerates cardiac dysfunction in obese male rats

Testosterone deprivation accelerates cardiac dysfunction in obese male rats

The relationship between serum sex hormone and cardiac echocardiographic findings in healthy men

Sex hormones and heart failure. Letter regarding the article ‘Pre‐diagnostic free androgen and estradiol levels influence heart failure risk in both women and men: A prospective cohort study in the UK Biobank’

Contact Info

Product

Resources

About