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citations
Cited by 37 publications
(55 citation statements)
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“…Rats studied immediately after coronary occlusion had decreased left ventricular (LV) fractional shortening (FS) of the cross-sectional area (unpublished data). Two days later, the SF presented values that remained stable until the later stages of remodeling and CHF 20,22 . In the early stages, the impaired contractility of the remaining myocardium does not contribute to ventricular dysfunction.…”
Section: Left Ventricle Diastolic Volume (Ml)mentioning
confidence: 93%
See 2 more Smart Citations
“…Rats studied immediately after coronary occlusion had decreased left ventricular (LV) fractional shortening (FS) of the cross-sectional area (unpublished data). Two days later, the SF presented values that remained stable until the later stages of remodeling and CHF 20,22 . In the early stages, the impaired contractility of the remaining myocardium does not contribute to ventricular dysfunction.…”
Section: Left Ventricle Diastolic Volume (Ml)mentioning
confidence: 93%
“…The myocardium must be frozen several times to achieve necrosis, and the lesion is not always transmural, and often the maneuvers to induce myocardial hypothermia cause permanent asystole. More recently, we described 20 an original model for the induction of myocardial necrosis in the LV of rats, with radiofrequency ablation (RFA), using electrical current as the technique routinely used in clinical practice to correct arrhythmias. The purpose was to find a technique that produced MI with less variability in size, and lower incidence of mortality.…”
Section: Left Ventricle Diastolic Volume (Ml)mentioning
confidence: 99%
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“…Papillary muscle preparation: After urethane (400 mg/kg, ip) anesthesia, the heart was quickly removed and placed in oxygenated Krebs-Henseleit solution. As described in previous publications by our laboratory 18,21,22) papillary muscles were dissected free, mounted between 2 spring clips, and placed vertically in a chamber containing Krebs-Henseleit solution (composition in mmol: NaCl, 130; KCl, 5.0; MgCl 2 , 1.2; CaCl 2 , 1.5; glucose, 11; HEPES, 20; insulin, 10 U; pH 7.4) at 30°C and oxygenated with 100% O 2 . The lower spring was attached to a hook at the bottom of the chamber by a thin steel wire, and the upper spring was connected by a thin steel wire to a Grass FTO3E force transducer (Astro-Med Inc., Grass Instrument Division, West Warwick, RI, USA) that was attached to a micromanipulator (Mitutoyo, model 2046 F, São Paulo, SP, Brazil) which allowed muscle length variation (10 μm/turn).…”
Section: Methodsmentioning
confidence: 97%
“…We therefore hypothesized that NHE3, the major apical transcellular pathway for sodium reabsorption in the proximal tubule, might be upregulated in heart failure. To test this hypothesis, we employed both stationary in vivo microperfusion and pH-dependent sodium uptake to verify whether NHE3 activity would be altered in the proximal tubule of an experimental model of heart failure (Antonio et al, 2009). Our data demonstrated that heart failure rats display enhanced NHE3-mediated sodium reabsorption in the proximal tubule which may contribute to extracellular volume expansion and edema.…”
Section: Heart Failurementioning
confidence: 99%