Left-sided EEG focus and positive psychiatric family history are independent risk factors for affective disorders in temporal lobe epilepsy

Torres, Carolina Machado; Assmann, Juliana Bohn; Fontana, Vivian; Rigotti, Clarice Pereira; Hidalgo, María Paz Loayza; Chaves, Márcia Lorena Fagundes; Bianchin, Marino Muxfeldt

doi:10.1016/j.eplepsyres.2009.08.010

Cited by 18 publications

(6 citation statements)

References 61 publications

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“…In our patients with temporal lobe epilepsy (TLE), we observed high levels of psychiatric comorbidities, and our results are comparable to those reported for European populations [5,6]. Some data suggest that genetic and anatomically common neural networks might merge together leading to the development of psychiatric comorbidities in epilepsy [7][8][9][10].…”

Section: Introductionsupporting

confidence: 92%

Impact of the chronic use of benzodiazepines prescribed for seizure control on the anxiety levels of patients with epilepsy

Pizzol

Martin

Mattiello

et al. 2012

Epilepsy & Behavior

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In a cross-sectional study, we evaluated the impact of the chronic use of benzodiazepines (BDZ) prescribed for seizure control on the anxiety levels of patients with temporal lobe epilepsy. We assessed the anxiety level of 99 patients with temporal lobe epilepsy with (n=15) or without (n=84) BDZ for seizure control, using the Beck Anxiety Inventory (BAI) or the Hamilton Anxiety Scale (HAMA). Independent risk factors for high anxiety levels were being a female patient (O.R.=2.93; 95% C.I.=1.05-8.16; p=0.039), having uncontrolled seizures (O.R.=4.49; 95% C.I.=1.66-12.11; p=0.003) and having a history of a psychiatric disorder (O.R.=4.46; 95% C.I.=1.63-12.21; p=0.004). However, there were no statistically significant differences in anxiety levels between patients utilizing or not utilizing BDZ prescribed exclusively for seizure control. We concluded that in our study, patients with chronic use of BDZ prescribed exclusively for seizure control showed similar anxiety levels than patients who were not using this class of drug. Additional studies are needed to define better strategies for the treatment of anxiety disorders in epilepsy.

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Section: Introductionsupporting

confidence: 92%

Impact of the chronic use of benzodiazepines prescribed for seizure control on the anxiety levels of patients with epilepsy

Pizzol

Martin

Mattiello

et al. 2012

Epilepsy & Behavior

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“…Bragatti et al showed that 54 % had psychiatric disorders out of whom 42.3% had mood disorders. 11 In a study by Edeh and Toone showed that 48% of patients with epilepsy had co-morbid psychiatric disorder. 12 One study done by Manchanda et al showed that 47.3% patients with epilepsy had psychiatric comorbidity and 4.3 had psychotic disorder.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of psychiatric comorbidities among the patients of epilepsy attending general hospital psychiatric unit

Rani¹,

Arora²,

Garg³

et al. 2018

Int. J. Curr. Res. Med. Sci.

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Background: Depression is most common psychiatric disorder in patients with epilepsy and it is the significant cause of morbidity. 1 Upto 50-60 percent of patients with epilepsy may develop psychiatric complications, particularly depression, anxiety, and psychotic disorders. 2 There is growing evidence of biological link between depression and epilepsy, and significant factors involved are the biological amines and gamma amino butyric acid (GABA) 3 along with other neurobiological and psychosocial factors. This study assess the symptoms and severity of psychiatric comorbidities in patients diagnosed with epilepsy. Methods and Findings: This study was conducted on patients attending psychiatric outpatient epilepsy clinic in psychiatry department, government medical college, Amritsar. A total of 40 patients were studied to find out the prevalence and severity of depression by using self applicable questionnaire, Beck depression inventory (BDI), 4 and MINI, in patients who are diagnosed with epilepsy by clinical interview and examination by senior psychiatrist consultant. In the results of our study 50% patients had psychiatric co-morbidities.40% had depressive disorder. Depression is found to be more among females in our study. 22.5 % were females and 17.5% were males. Among depressed patients, 22.5% had severe depression. Prevalence of moderate depression was 15% , and 2.5 % had borderline clinical depression, 5% had psychosis, and 5% had substance dependence. Conclusion: Diagnosing psychiatric co-morbidities can be difficult in patients with epilepsy. The treatment of both epilepsy and depression need for close collaboration. Patient taking antiepileptic medication may have symptoms of depression as a result of their treatment. Sadly, data from drug trials are often helpful. The antiepileptic medications most closely associated with acute depression on initiation of treatment are vigabatrin, phenobarbitone, and topiramate. Depression with topiramate may be due to abrupt cessation of seizures or drug toxicity. Patients starting tiagabine may develop symptoms of agitation, withdrawal, and mood disturbance suggestive of depression;. Thus good awareness and recognition of psychiatric conditions can help a long way in improving the quality of care of patients with epilepsy.

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“…Bragatti et al [11] studied the EEG of 97 patients with TLE who underwent a psychiatric evaluation and were classified using DSM-IV. In total, 53.6% of patients presented mental disorders from axis I of this classification system: 78.9% were mood disorders, 38.5% were anxiety disorders, 11.5% psychosis, and 11.5% either alcohol or drug abuse.…”

Section: Discussionmentioning

confidence: 99%

Electroencephalogram alterations associated with psychiatric disorders in temporal lobe epilepsy with mesial sclerosis: A systematic review

Lourenço

Marques

Filho

2020

Epilepsy & Behavior

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Temporal lobe epilepsy (TLE) is the most frequent focal epilepsy in adults and has been associated with psychiatric disorders (PD), especially the TLE with mesial temporal sclerosis (MTS). Electroencephalogram (EEG) could help in locating the epileptogenic zone and supply information regarding cerebral electric activity in these patients. However, there is a scarcity of knowledge about the association between EEG findings and comorbid PD in TLE. The objective of this review was to proceed a systematic review about the association of interictal EEG findings and PD in patients with TLE-MTS. A PRISMA model was used, and MEDLINE, CENTRAL, LILACS, and CAPES databases were searched. Six articles were considered in this review based on the inclusion/exclusion criteria. Results showed few published studies and contradicting conclusions regarding the association of EEG and PD in TLE-MTS. We observed great heterogeneity regarding the populations analyzed, hindering the comparison between the studies found. Studies with greater methodological robustness are needed to better understand the role of EEG as a possible biomarker for PD in TLE-MTS.

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Left-sided EEG focus and positive psychiatric family history are independent risk factors for affective disorders in temporal lobe epilepsy

Cited by 18 publications

References 61 publications

Impact of the chronic use of benzodiazepines prescribed for seizure control on the anxiety levels of patients with epilepsy

Impact of the chronic use of benzodiazepines prescribed for seizure control on the anxiety levels of patients with epilepsy

Prevalence of psychiatric comorbidities among the patients of epilepsy attending general hospital psychiatric unit

Electroencephalogram alterations associated with psychiatric disorders in temporal lobe epilepsy with mesial sclerosis: A systematic review

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