Left Prefrontal High-Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Schizophrenia with Predominant Negative Symptoms: A Sham-Controlled, Randomized Multicenter Trial

Wobrock, Thomas; Guse, Birgit; Cordes, Joachim; Wölwer, Wolfgang; Winterer, Georg; Gäebel, Wolfgang; Langguth, Berthold; Landgrebe, Michael; Eichhammer, Peter; Frank, Elmar; Hajak, Göran; Ohmann, Christian; Verde, Pablo Emilio; Rietschel, Marcella; Ahmed, Rayaz; Honer, William G.; Malchow, Berend; Schneider‐Axmann, Thomas; Falkai, Peter; Hasan, Alkomiet

doi:10.1016/j.biopsych.2014.10.009

Cited by 134 publications

(153 citation statements)

References 61 publications

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“…Case reports and case series, single-session studies, abstracts of congress presentations, reviews, and meta-analyses were excluded. Furthermore, the recent meta-analyses on persistent auditory hallucinations and negative symptoms, 20,21 as well the latest large-scale clinical trials in the field, 9,10 were also screened for citations not revealed by the systematic literature search. Full-text articles were then analyzed with respect to the presentation of cognitive measures as primary or secondary outcome parameters.…”

Section: Methodsmentioning

confidence: 99%

“…These 76 full-text articles were then analyzed regarding the presentation of any cognitive measures before and after NIBS intervention. In total, 33 primary studies published between 1999 and 2015 9,[13][14][15]22,23, were included for further analyses in this systematic review. All other full texts (N = 43) were excluded due to the lacking presentation of cognitive measures.…”

Section: Study Selectionmentioning

confidence: 99%

“…5 Common to all is the possibility to induce longlasting changes in brain excitability, to modulate cortical connectivity and network plasticity. 6,7 One consensus paper 8 provides evidence for a moderate clinical efficacy of rTMS for the treatment of persistent auditory hallucinations (temporal lobe stimulation) and predominant negative symptoms (frontal lobe stimulation), although recent studies with relevant sample sizes 9,10 are questioning these statements. One tDCS pilot study showed that S96 A. Hasan et al tDCS can improve both auditory hallucinations as well as negative symptoms in severely affected schizophrenia patients.…”

Section: Introductionmentioning

confidence: 99%

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Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Hasan

Strube

Palm

et al. 2016

SCHBUL

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Despite many years of research, there is still an urgent need for new therapeutic options for the treatment of cognitive deficits in schizophrenia. Noninvasive brain stimulation (NIBS) has been proposed to be such a novel add-on treatment option. The main objective of this review was to systematically evaluate the cognitive effects of repetitive NIBS in schizophrenia. As most studies have not been specifically designed to investigate cognition as primary outcome, we have focused on both, primary and secondary outcomes. The PubMed/MEDLINE database (1985-2015) was systematically searched for interventional studies investigating the effects of repetitive NIBS on schizophrenia symptoms. All interventional clinical trials using repetitive transcranial stimulation, transcranial theta burst stimulation, and transcranial direct current stimulation for the treatment of schizophrenia were extracted and analyzed with regard to cognitive measures as primary or secondary outcomes. Seventy-six full-text articles were assessed for eligibility of which 33 studies were included in the qualitative synthesis. Of these 33 studies, only 4 studies included cognition as primary outcome, whereas 29 studies included cognitive measures as secondary outcomes. A beneficial effect of frontal NIBS could not be clearly established. No evidence for a cognitive disruptive effect of NIBS (temporal lobe) in schizophrenia could be detected. Finally, a large heterogeneity between studies in terms of inclusion criteria, stimulation parameters, applied cognitive measures, and follow-up intervals was observed. This review provides the first systematic overview regarding cognitive effects of repetitive NIBS in schizophrenia.

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Section: Methodsmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Hasan

Strube

Palm

et al. 2016

SCHBUL

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“…The stimulation protocol was 15 sessions of 10 Hz stimulation of the left DLPFC, 110% MT, 5 s train and 30 s intertrain, and 15,000 pulses in the whole study. However, less-precise method was used for targeting the left DLPFC (the international system of EEG electrode placement 10/20, F3 electrode), and patients received a relatively small number of pulses, although the last meta-analysis indicated that a higher number of pulses have a better effect [30].…”

Section: Current Results Of Rtms In the Treatment Of Negative Symptomsmentioning

confidence: 99%

Transcranial Magnetic Stimulation in Schizophrenia

Ustohal¹,

Svěrák²,

Albrechtová³

et al. 2016

Schizophrenia Treatment - The New Facets

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Transcranial magnetic stimulation (TMS) is a method that can be used in neurophysiological research of schizophrenia and in the treatment of some symptoms or syndromes of this mental disorder. The most important indications for TMS (or repetitive TMSrTMS) are the negative symptoms of schizophrenia and auditory hallucinations. Other less proven indications include cognitive deficit, especially working memory. This text summarizes general knowledge about (r)TMS and its use in schizophrenia. According to recent experiences, TMS is a very promising experimental and therapeutic method, but it needs further research for its optimized use.

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“…However, there was a small, but statistically significant, improvement in positive symptoms in the active rTMS group, limited to day 21. They concluded that application of 10-Hz rTMS to the left DLPFC was well tolerated but was not found to be superior compared with sham rTMS in correcting negative symptoms [14]. Dlabac et al performed a meta-analysis with 9 randomized controlled trials including 213 patients, to assess the efficacy of prefrontal rTMS for managing negative symptoms of schizophrenia.…”

Section: Effect Of Rtms On Negative Symptomsmentioning

confidence: 99%

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

Sayar¹,

Bulut²,

Tarhan³

2015

J Neurol Neurol Sci Disord

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Left Prefrontal High-Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Schizophrenia with Predominant Negative Symptoms: A Sham-Controlled, Randomized Multicenter Trial

Cited by 134 publications

References 61 publications

Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Repetitive Noninvasive Brain Stimulation to Modulate Cognitive Functions in Schizophrenia: A Systematic Review of Primary and Secondary Outcomes

Transcranial Magnetic Stimulation in Schizophrenia

Use of Repetitive Transcranial Magnetic Stimulation in Treatment of Negative Symptoms of Schizophrenia

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