Left nucleus accumbens atrophy in deficit schizophrenia: A preliminary study

Rossi, Pietro De; Dacquino, Claudia; Piras, Fabrizio; Caltagirone, Carlo; Spalletta, Gianfranco

doi:10.1016/j.pscychresns.2016.06.004

Cited by 17 publications

(10 citation statements)

References 74 publications

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“…The demographic data of these 24 studies were entered into a database [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. The variables of which are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The primary diagnostic instruments used to define deficit schizophrenia in these papers were SDS [ 22 , 24 , 25 , 27 , 29 , 31 , 32 , 33 , 35 , 36 , 37 , 38 , 40 , 41 ], SANS [ 21 , 30 , 42 , 43 ], PNS [ 23 ], PANSS alongside The Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM-III) and Fourth Edition (DSM-IV) criteria [ 26 , 34 , 39 ] and PDS [ 20 , 28 ]. In some studies, more than one instrument of diagnostic classification was used.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, 13 studies employed the MRI ROI approach [ 20 , 22 , 24 , 26 , 27 , 28 , 29 , 30 , 36 , 40 , 41 , 42 , 43 ], six studies used VBM [ 21 , 23 , 25 , 31 , 33 , 39 ], four studies used diffusion tensor imaging (DTI) [ 34 , 35 , 37 , 38 ] and one study used both VBM and DTI [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Neuroanatomy of Patients with Deficit Schizophrenia: An Exploratory Quantitative Meta-Analysis of Structural Neuroimaging Studies

Chee

Chua

Morrin

et al. 2020

IJERPH

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Little is known regarding the neuroanatomical correlates of patients with deficit schizophrenia or persistent negative symptoms. In this meta-analysis, we aimed to determine whether patients with deficit schizophrenia have characteristic brain abnormalities. We searched PubMed, CINAHL and Ovid to identify studies that examined the various regions of interest amongst patients with deficit schizophrenia, patients with non-deficit schizophrenia and healthy controls. A total of 24 studies met our inclusion criteria. A random-effects model was used to calculate a combination of outcome measures, and heterogeneity was assessed by the I2 statistic and Cochran’s Q statistic. Our findings suggested that there was statistically significant reduction in grey matter volume (−0.433, 95% confidence interval (CI): −0.853 to −0.014, p = 0.043) and white matter volume (−0.319, 95% CI: −0.619 to −0.018, p = 0.038) in patients with deficit schizophrenia compared to healthy controls. There is also statistically significant reduction in total brain volume (−0.212, 95% CI: −0.384 to −0.041, p = 0.015) and white matter volume (−0.283, 95% CI: −0.546 to −0.021, p = 0.034) in patients with non-deficit schizophrenia compared to healthy controls. Between patients with deficit and non-deficit schizophrenia, there were no statistically significant differences in volumetric findings across the various regions of interest.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Neuroanatomy of Patients with Deficit Schizophrenia: An Exploratory Quantitative Meta-Analysis of Structural Neuroimaging Studies

Chee

Chua

Morrin

et al. 2020

IJERPH

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“…The VC/VS was our stimulation target in this patient population. This region is proximate to the nucleus accumbens, a structure commonly associated with reward processing, anhedonia, and motivation (67). Given these functions, it stands to reason that stimulation of VC/VS could have effects on mood and depression symptomatology in addition to OCD symptoms (68).…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Deep Brain Stimulation for Obsessive–Compulsive Disorder: A Long Term Naturalistic Follow Up Study in a Single Institution

et al. 2020

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Introduction: Deep brain stimulation (DBS) is a proven, effective tool in the treatment of movement disorders. Expansion of indications for DBS into the realm of neuropsychiatric disorders, especially obsessive-compulsive disorder (OCD), has gained fervent interest, although data on appropriate clinical utilization remains limited. Methods: A retrospective, naturalistic study followed nine severely affected OCD patients (average YBOCs score before implantation 34.2 ± 2.5) treated with DBS of ventral capsule/ventral striatum, with average follow up of 54.8 months. Results: With chronic stimulation (years), a majority of the patients achieved significant benefits in obsessive-compulsive and depressive symptoms. Six patients experienced periods of OCD remission following implantation. Four of the six responders required more than 12 months to achieve response. Relief of major depressive symptoms occurred in four out of six patients with documented co-morbid depression. Settings required to achieve efficacy were higher than those typically utilized for movement disorders, necessitating increased impulse generator (IPG) battery demand. We found patients benefited from conversion to a rechargeable IPG to prevent serial operations for IPG replacement. For patients with rechargeable IPGs, the repetitive habit of recharging did not appear to aggravate or trigger new obsessive-compulsive behaviors or anxiety symptoms. Conclusions: Our study supports and builds upon other research suggesting that DBS for OCD in a real-world setting can be implemented successfully and provide long-term benefit for severely affected OCD patients. Optimal patient selection and DBS programming criteria are discussed. The use of rechargeable IPGs appears to be both cost effective and well-tolerated in this population.

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“…In studies examining gray matter volume differences in selected regions of interest between DS and NDS, findings include for instance smaller gray matter volume in regions such as the right temporal lobe, 17 the superior frontal gyrus and the middle temporal gyrus, 18 and the left nucleus accumbens. 19 Some of the heterogeneity of findings between studies may be due to small study samples and different regions of interest investigated. When investigating whole brain gray matter differences between DS and NDS patients using voxel based morphometry, Cascella et al 20 identified several regions where DS patients had smaller gray matter volume compared with NDS, including the superior frontal gyrus, bilateral superior frontal gyrus and superior temporal gyrus, left supplementary motor area, left anterior cingulate, left insula, left cuneus and right putamen.…”

Section: Persistent Negative Symptoms and Deficit Schizophreniamentioning

confidence: 99%

The Neural Correlates of Negative Symptoms in Schizophrenia: Examples From MRI Literature

2017

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Negative symptoms of schizophrenia have a negative impact on psychosocial functioning and disease outcome. It is therefore important to investigate the pathophysiology underlying negative symptoms as this may aid the development of better treatment. In the current article, examples from studies investigating neural correlates of negative symptoms in schizophrenia are given. Investigations using both structural and functional magnetic resonance imaging are presented at different levels of symptomatology descriptions, from the more heterogenous construct of negative symptoms to more single discrete symptoms. Some methods to improve imaging studies of negative symptoms in schizophrenia are also suggested.

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Left nucleus accumbens atrophy in deficit schizophrenia: A preliminary study

Cited by 17 publications

References 74 publications

Neuroanatomy of Patients with Deficit Schizophrenia: An Exploratory Quantitative Meta-Analysis of Structural Neuroimaging Studies

Neuroanatomy of Patients with Deficit Schizophrenia: An Exploratory Quantitative Meta-Analysis of Structural Neuroimaging Studies

Deep Brain Stimulation for Obsessive–Compulsive Disorder: A Long Term Naturalistic Follow Up Study in a Single Institution

The Neural Correlates of Negative Symptoms in Schizophrenia: Examples From MRI Literature

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