2020
DOI: 10.3390/diagnostics10030137
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Abstract: Left atrial structural, functional and electrical remodelling are linked to atrial fibrillation (AF) pathophysiology and mirror the phrase “AF begets AF”. A structurally remodelled left atrium (LA) is fibrotic, dysfunctional and enlarged. Fibrosis is the hallmark of LA structural remodelling and is associated with increased risk of stroke, heart failure development and/or progression and poorer catheter ablation outcomes with increased recurrence rates. Moreover, increased atrial fibrosis has been associated w… Show more

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Cited by 18 publications
(19 citation statements)
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“…We read with great interest the excellent article written by Seewöster et al 1 In atrial fibrillation (AF), left atrial (LA) fibrosis and dysfunction, biomarkers as atrial natriuretic peptide (ANP), delayed enhancement areas and low voltage areas (LVAs) are related to atrial cardiomyopathy and atrial failure. 2,3 Indeed, NT-proANP could be a missing link in LVAs prediction, 1 but there are some issues.…”
Section: Low Voltage Areas Atrial Natriuretic Peptides and Fibrosis:mentioning
confidence: 99%
See 2 more Smart Citations
“…We read with great interest the excellent article written by Seewöster et al 1 In atrial fibrillation (AF), left atrial (LA) fibrosis and dysfunction, biomarkers as atrial natriuretic peptide (ANP), delayed enhancement areas and low voltage areas (LVAs) are related to atrial cardiomyopathy and atrial failure. 2,3 Indeed, NT-proANP could be a missing link in LVAs prediction, 1 but there are some issues.…”
Section: Low Voltage Areas Atrial Natriuretic Peptides and Fibrosis:mentioning
confidence: 99%
“…LVAs detected by electroanatomical mapping are a surrogate for LA fibrosis, best assessed by late gadolinium enhancement. 3 The 0.5 mV threshold was arbitrarily chosen for LVAs. Despite this, fractioned electrograms seem to be exactly in these areas.…”
Section: Low Voltage Areas Atrial Natriuretic Peptides and Fibrosis:mentioning
confidence: 99%
See 1 more Smart Citation
“…One such cause is from prolonged exposure to risk factors which promote fibrogenesis, such as hypertension, diabetes, or congestive cardiac failure. 8,9 Myocyte loss and fibrosis results in a reduction of ion channels and fibers which are integral to contractility. Atrial dilation is a late feature of this fibrotic process, and greater accommodation of re-entry circuits is possible through progressively increased atrial size.…”
Section: Pathophys Iology Of Myoc Ardial Remodeling In Afmentioning
confidence: 99%
“…Pulmonary vein "PV" Ostia are the sources of ectopy and scar related substrates that initiate and promote AF. 8 The diameter of the PVs may play a pivotal role. 11 Hence, circumferential isolation of all PVs, has established itself as a mainstay of treatment for AF.…”
Section: Pulmonary Vein P Otential S and Antr Al Sc Armentioning
confidence: 99%