Left atrial size and contractile function in healthy dogs and dogs with chronic mitral valve disease

Petrus, Lilian Caram; Castro, Jairo Lopes de; Mantovani, Matheus Matioli; Gimenes, André Martins; Duarte, Caio Nogueira; Goldfeder, Guilherme Teixeira; Schwartz, Denise Saretta; Larsson, Maria

doi:10.1590/1678-5150-pvb-5114

Cited by 3 publications

(2 citation statements)

References 25 publications

(53 reference statements)

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“…Left atrium enlargement is accepted as a result of pressure or volume overload and reflects systolic and diastolic dysfunction 18 . The relationship between LA enlargement and increased sympathetic activity has been shown in cats with anesthetic protocol 2.…”

Section: Resultsmentioning

confidence: 99%

The effects of anesthetic drug choice on heart rate variability and echocardiography parameters in cats

Panprom,

Pattanapon,

Petchdee

2024

Sci Rep

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Heart rate variability (HRV) is one of the assessments of cardiovascular risk during general anesthesia. This study aimed to assess the effects of an anesthetic drug on HRV in cats and to provide information for clinical applications. Twenty-four healthy client-owned cats of various breeds, 12 females and 12 males scheduled for elective surgery, were enrolled in this study. The cats were premedicated and induced with 4 protocols: protocol 1, diazepam (0.3 mg/kg) and propofol (2–4 mg/kg) IV; protocol 2, diazepam (0.3 mg/kg) and alfaxalone (1–3 mg/kg) IV; protocol 3, diazepam (0.3 mg/kg) and ketamine (3–5 mg/kg) IV; and protocol 4, xylazine (1 mg/kg) and tiletamine/zolazepam (Zoletil) (5 mg/kg) IM. The heart rate and HRV of the 24 cats were collected before and at least 1 h after administering the anesthetic drugs. Echocardiography was performed to evaluate heart function. Oscillometric blood pressure monitoring was used to obtain the mean blood pressure. After anesthetic drug administration, higher heart rates were found in cats premedicated and induced with alfaxalone (p = 0.045) than in the other protocols. The lowest heart rate (HR) values were found in cats in protocol 4 using xylazine and Zoletil. The HRV low frequency (LF) and high frequency (HF) power ratios increased in all protocols except for cats premedicated and intubated with propofol. The standard deviation of the regular sinus beats (SDNN) was higher in cats premedicated and induced with ketamine than in other anesthetic protocols (p = 0.015). An increase in sympathetic activity and reduced HRV is associated with high blood pressure and left atrial dimension. The percentage of fractional shortening (FS) decreased in cats premedicated with ketamine. The results showed that the anesthesia method using diazepam and propofol caused the least disturbance of HRV compared with other anesthesia methods that were used in this study.

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Section: Resultsmentioning

confidence: 99%

The effects of anesthetic drug choice on heart rate variability and echocardiography parameters in cats

Panprom,

Pattanapon,

Petchdee

2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Sympathetic activity is increased and correlated with the left atrium (LA) dimension. Left atrium enlargement is accepted as a result of pressure or volume overload and reflects systolic and diastolic dysfunction 19 . The relationship between LA enlargement and increased sympathetic activity has been shown in cats with anesthetic protocol 2.…”

Section: Resultsmentioning

confidence: 99%

The effects of anesthetic drug choice on heart rate variability and echocardiography parameters in cats

Panprom,

Pattanapon,

Petchdee

2023

Preprint

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Heart rate variability (HRV) is one of the assessments of cardiovascular risk during general anesthesia. This study aimed to assess the effects of an anesthetic drug on HRV in cats and to provide information for clinical applications. Twenty-four healthy client-owned cats of various breeds, 12 females and 12 males scheduled for elective surgery, were enrolled in this study. The cats were premedicated and induced with 4 protocols: protocol 1, diazepam (0.3 mg/kg) and propofol (2-4 mg/kg); protocol 2, diazepam (0.3 mg/kg) and alfaxalone (1-3 mg/kg); protocol 3, diazepam (0.3 mg/kg) and ketamine (3-5 mg/kg); and protocol 4, xylazine (1 mg/kg) and tiletamine/zolazepam (Zoletil) (5 mg/kg). The heart rate and HRV of the 24 cats were collected before and at least 1 hour after administering the anesthetic drugs. Echocardiography was performed to evaluate heart function. Doppler was used to obtain the mean blood pressure. After anesthetic drug administration, higher heart rates were found in cats premedicated and induced with alfaxalone (p = 0.045) than in the other protocols. The lowest heart rate (HR) values were found in cats in protocol 4 using xylazine and Zoletil. The HRV low frequency (LF) and high frequency (HF) power ratios increased in all protocols except for cats premedicated and intubated with propofol. The standard deviation of the regular sinus beats (SDNN) was higher in cats premedicated and induced with ketamine than in other anesthetic protocols (p=0.015). An increase in sympathetic activity and reduced heart rate variability is associated with high blood pressure and left atrial dimension. The percentage of fractional shortening (FS) decreased in cats premedicated with ketamine. The results showed that the anesthesia method using diazepam and propofol was more effective in maintaining cardiovascular function than other anesthesia methods that were used in this study.

show abstract

The effects of anesthetic drug choice on heart rate variability and echocardiography parameters in cats

Panprom

Pattanapon

Petchdee

2023

Preprint

View full text Add to dashboard Cite

Heart rate variability is one of the assessments for cardiovascular risk during general anesthesia. The aims of this study were to assess the effects of an anesthetic drug on heart rate and heart rate variability (HRV) in cats and to provide the information for clinical applications. Twenty-four healthy client-owned cats of various breeds, 12 females and 12 males scheduled for elective surgery, were enrolled in this study. The cats were premedicated and induced with 4 protocols: protocol 1, diazepam (0.3 mg/kg) and propofol (3 mg/kg); protocol 2, diazepam (0.3 mg/kg) and alfaxalone (3 mg/kg); protocol 3, diazepam (0.3 mg/kg) and ketamine (5 mg/kg); and protocol 4, xylazine (1 mg/kg) and tiletamine/zolazepam (Zoletil) (5 mg/kg). The heart rate and heart rate variability of the 24 cats were collected before and at least 1 hour after administering the anesthetic drugs. Echocardiography was performed to evaluate heart function. Doppler was used to obtain the mean blood pressure. After anesthetic drug administration, higher heart rates were found in cats premedicated and induced with alfaxalone (p = 0.045) than in the other protocols, and the lowest heart rate (HR) values were found in cats in protocol 4 using xylazine and Zoletil. The HRV low frequency (LF) and high frequency (HF) power ratios increase in all protocols except for cats premedicated and intubation with propofol. The standard deviation of the normal sinus beats (SDNN) was higher in cats premedicated and induced with ketamine than in other anesthetic protocols (p = 0.015). An increase in sympathetic activity and reduced heart rate variability is associated with high blood pressure and left atrial dimension. The percentage of fractional shortening (FS) decreased in cats premedicated with ketamine. This study demonstrated that an anesthetic protocol using diazepam and propofol preserved cardiovascular function and was safe to use for surgeries in cats.

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Left atrial size and contractile function in healthy dogs and dogs with chronic mitral valve disease

Cited by 3 publications

References 25 publications

The effects of anesthetic drug choice on heart rate variability and echocardiography parameters in cats

The effects of anesthetic drug choice on heart rate variability and echocardiography parameters in cats

The effects of anesthetic drug choice on heart rate variability and echocardiography parameters in cats

The effects of anesthetic drug choice on heart rate variability and echocardiography parameters in cats

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