Lectins as Cell Recognition Molecules

Sharon, Nathan; Lis, Halina

doi:10.1126/science.2552581

Cited by 1,113 publications

(565 citation statements)

References 88 publications

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“…Their involvement in diverse biological processes in many species, 3 such as clearance of glycoproteins from the circulatory system, 4,5 adhesion of infectious agents to host cells, 6 recruitment of leukocytes to inflammatory sites, 7 cell interactions in the immune system, in malignancy and metastasis, 8 has been shown. A doctoral thesis from 1888 on the agglutination of red blood cells by extracts of castor beans (the active component being a protein named ricin) is often cited as the beginning of lectinology, 9 however the agglutination of erythrocytes by rattlesnake venom, observed around 1860, 10 has in fact been suggested as the first demonstrated example of lectin activity.…”

Section: Lectinsmentioning

confidence: 99%

Lectins: Tools for the Molecular Understanding of the Glycocode

2005

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Recent progress in glycobiology has revealed that cell surface oligosaccharides play an essential role in recognition events. More precisely, these saccharides may be complexed by lectins, carbohydrate-binding proteins other than enzymes and antibodies, able to recognise sugars in a highly specific manner. The ubiquity of lectin-carbohydrate interactions opens enormous potential for their exploitation in BA (1993) and DPhil (1996) T h i s j o u r n a l i s © T h e R o y a l S o c i e t y o f C h e m i s t r y

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Section: Lectinsmentioning

confidence: 99%

Lectins: Tools for the Molecular Understanding of the Glycocode

2005

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“…Efficient adhesion allows the pathogen to escape the natural cleansing mechanisms of the host and provides a means for access to nutrients, delivery of toxins and ultimately colonization and invasion of the host, including biofilm formation [1]. In most cases, molecular recognition is triggered by specific carbohydrate-protein interactions involving glycoconjugates and sugar-binding protein (lectins).…”

Section: Microbial Adhesion and Carbohydratesmentioning

confidence: 99%

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives

Sattin

Bernardi

2016

Trends in Biotechnology

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Microbial adhesion is an essential step of infections and is mediated primarily by proteincarbohydrate interactions. Antagonists of such interactions have become a promising target for antiadhesive therapy in a number of infective diseases. Monovalent protein-sugar interactions are often weak, and most successful antiadhesive materials consist of multivalent glycoconjugates.Although often very effective in hampering microbial adhesion, natural epitopes often show limited resistance to enzymatic degradation. The use of carbohydrate mimics (glycomimetics) as a replacement for natural sugars potentially allows to achieve higher metabolic stability and also higher selectivity towards the desired protein target. In this review we will describe the state of the art on the design and synthesis of glycoconjugates and glycomimetics employed for the construction of antiadhesive biomaterials.

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“…Lectins are proteins that bind to carbohydrates speci¢cally and noncovalently (Sharon & Lis 1989). Based on results of lectin-binding intensities to Coullana sp.…”

Section: (C) Mate Recognition and The Role Of Contact Chemical Cuesmentioning

confidence: 99%

The influence of contact chemical signals on mate recognition in an harpacticoid copepod

Frey

Lonsdale

Snell

1998

Phil. Trans. R. Soc. Lond. B

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Among copepods, reproduction is facilitated by a combination of sensory modalities, such as mechano-and chemoreception. The role of chemical communication in copepod mate recognition was assessed using behavioural bioassays that were based on precopulatory behaviours of an estuarine harpacticoid, Coullana canadensis, and the sibling species Coullana sp. Intra-and interspeci¢c crosses demonstrated that males recognize genetically distinct conspeci¢c and heterospeci¢c females, indicating that prezygotic isolation remains incomplete. There was no association between the frequency of mate-guarding behaviour and geographic distance between populations of C. canadensis. However, reduced levels of interspeci¢c mate guarding relative to intraspeci¢c frequencies suggest the existence of a species-speci¢c mate-recognition system. Lectins, which possess strong a¤nities for speci¢c carbohydrate groups, were used to con¢rm that glycoproteins on the surface of females function as mate-recognition factors. Information regarding the chemical composition of these molecules was derived from observed e¡ects of lectin binding to females on male mate-guarding behaviour. Mate guarding was inhibited within all tested populations when treated withTriticum vulgaris, a lectin that possesses an a¤nity for carbohydrates of the N-acetylglucosamine group. Surface glycoproteins responsible for mate recognition in the two species of Coullana may be glycosylated with monosaccharides from this group. Di¡erential responses to lectin treatments suggested that composition of the contact chemical cues vary among populations of C. canadensis and between species. Yet, populations that appeared most similar based on shared lectin responses successfully discriminated against each other in mate-selection experiments. These ¢ndings indicate that contact chemical cues probably act in concert with additional factors to promote e¡ective mate recognition and thereby contribute to reproductive success.

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Lectins as Cell Recognition Molecules

Abstract: Lectins on cell surfaces mediate cell-cell interactions by combining with complementary carbohydrates on apposing cells. They play a key role in the control of various normal and pathological processes in living organisms.

Cited by 1,113 publications

References 88 publications

Lectins: Tools for the Molecular Understanding of the Glycocode

Lectins: Tools for the Molecular Understanding of the Glycocode

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives

The influence of contact chemical signals on mate recognition in an harpacticoid copepod

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