Lecithin-based nanoemulsions

Klang, Victoria; Valenta, Claudia

doi:10.1016/s1773-2247(11)50006-1

Cited by 189 publications

(121 citation statements)

References 154 publications

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“…Generally, it was expected that the incorporation of DZM into nanoemulsion would enlarge the droplet size, since additional lipophilic molecules need to be solubilized in the oil phase [1]. However, the obtained results also imply a possible interaction between DZM and emulsifier layer and, consequently, partial drug localization in the o/w interface leading to the reduction of the surface tension and therefore the droplet size, during the homogenization step [11,19].…”

Section: Resultsmentioning

confidence: 89%

“…Concerning the oil phase, MCT and SO, as the most widely used oils in the commercially available parenteral lipid emulsions [1,14] were selected, whereas lecithin and polysorbate 80 were used as emulsifiers for the nanoemulsion preparation. The oil-emulsifier ratio was kept constant at 5:1 (w/w) in all formulations.…”

Section: Resultsmentioning

confidence: 99%

“…Considering the formulation and physicochemical characteristics, nanoemulsions have been associated with a number of advantages such as a low surfactant concentration, a uniform and very small droplet size, low viscosity, and high solubilization capacity for lipophilic drugs. Additionally, the improved penetration through biological barriers, possible enhanced bioavailability and organ targeting could be expected with these systems [1][2][3][4][5][6]. Although lipid nanoemulsions have been traditionally employed for parenteral nutrition and intravenous delivery of lipophilic drugs -with several approved products on the market -the additional efforts are required to optimize nanoemulsion formulation, stability, and overall drug delivery [1,7].…”

Section: Introductionmentioning

confidence: 99%

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A full factorial design in the formulation of diazepam parenteral nanoemulsions: Physicochemical characterization and stability evaluation

Cekić¹,

Đorđević²,

Savić³

et al. 2015

Savr tehnol

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Using the experimental design methodology, we have developed and characterized nanoemulsions for a parenteral delivery using diazepam as a model drug. The formulations containing 20 or 30% (w/w) of medium chain triglycerides or the mixture of medium chain triglycerides and soybean oil as the oil phase, soybean lecithin and polysorbate 80 as emulsifiers, and a phosphate buffer solution as the aqueous phase were prepared by cold high pressure homogenization. The obtained nanoemulsions were evaluated in terms of droplet size, size distribution, surface charge, drug-vehicle interactions and physical stability. To evaluate the effects of the oil phase type, oil content and drug presence, as well as their interactions on critical quality attributes of nanoemulsions, a three-factor two-level full factorial design was applied. After the preparation, all nanoemulsions revealed small spherical droplets in the range 170-210 nm, with the narrow droplet size distribution (< 0.15) and the surface charge about -60 mV. The experimental design results indicated that not only factors alone (oil type, oil content, presence of drug), but their interactions also had a significant effect on the nanoemulsion droplet size, polydispersity index, and zeta potential. During two months of storage at 25 °C, all nanoemulsions formulated with the medium chain triglycerides-soybean oil mixture (4:1, w/w) remained physically stable, without considerable changes in monitored parameters. Physicochemical characteristics and stability of these nanoemulsions demonstrated their suitability for parenteral drug delivery.

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A full factorial design in the formulation of diazepam parenteral nanoemulsions: Physicochemical characterization and stability evaluation

Cekić¹,

Đorđević²,

Savić³

et al. 2015

Savr tehnol

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“…Dodatno, poboljšana penetracija kroz biološke barijere, povećanje biološke raspoloživosti, smanjenje iritacije i/ili toksičnosti, produženo oslobađanje i ciljna isporuka lekovite supstance u različite organe mogu se očekivati nakon primene nanoemulzionih sistema (4)(5)(6). Na osnovu navedenih činjenica, ne iznenađuje da nanoemulzije predstavljaju privlačnu alternativu za savladavanje krvnomoždane barijere i poboljšanu isporuku slabo rastvorljivih psihofarmakoloških lekovitih supstanci (kakav je diazepam) u mozak, parenteralnim putem, naročito u urgentnim stanjima i kada postoje problemi sa gutanjem.…”

Section: Lekovita Supstancaunclassified

“…U skladu sa načinom primene, parenteralne nanoemulzije izrađuju se iz visoko bezbednih i biokompatibilnih ulja (sojino, trigliceridi srednje dužine lanca, suncokretovo, maslinovo, riblje) i emulgatora (fosfolipidi, polisorbati, poloksameri), najčešće metodom homogenizacije pod visokim pritiskom (6,7). Komercijalno dostupni preparati nanoemulzija uglavnom sadrže 10 ili 20% uljane faze; povećanje udela ulja omogućilo bi inkorporiranje veće količine liposolubilne lekovite supstance, a otuda i smanjenje volumena injektovanja ili infuzije.…”

Section: Lekovita Supstancaunclassified

Diazepam-loaded parenteral nanoemulsions: Physicochemical characterization and in vitro release study

Djordjevic¹,

Isailović²,

Cekić³

et al. 2016

Arh farmaciju

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Cilj ovog istraživanja bio je da se razviju parenteralne nanoemulzije sa rastućom koncentracijom uljane faze (20, 30 i 40% smeše triglicerida srednje dužine lanca i sojinog ulja u odnosu 4:1), stabilizovane kombinacijom lecitina i polisorbata 80, i da se proceni njihova pogodnost kao nosača za slabo rastvorljive psihofarmakološke lekovite supstance. U tu svrhu, homogenizacijom pod visokim pritiskom izrađene su nanoemulzije sa diazepamom kao model lekovitom supstancom i okarakterisane u pogledu veličine kapi, indeksa polidisperznosti, površinskog naelektrisanja, viskoziteta, pH vrednosti i električne provodljivosti. Takođe, primenom reverzne tehnike sa dijaliznim vrećicama procenjena je brzina oslobađanja diazepama iz razvijenih nanoemulzija, uz karakterizaciju dobijenih profila oslobađanja primenom različitih matematičkih modela. Nakon izrade, sve formulacije imale su malu prosečnu veličinu kapi (206 ± 7 nm), sa uskom raspodelom veličina (0,116 ± 0,012) i zeta potencijalom oko -50 mV, što je u skladu sa farmakopejskim zahtevima (USP 39-NF 34) pri čemu se vrednosti navedenih parametara nisu značajno promenile nakon godinu dana čuvanja na 25 ± 2°C. In vitro ispitivanje brzine oslobađanja pokazalo je da se 40-50% diazepama oslobodi iz ispitivanih nanoemulzija tokom 1 h, pri čemu se kinetika oslobađanja može opisati Korsmeyer-Peppas modelom. Dobijeni rezultati ukazuju da formulisane parenteralne nanoemulzije predstavljaju obećavajuće nosače za brzu isporuku slabo rastvorljivih psihofarmakoloških lekovitih supstanci.Ključne reči: nanoemulzija; parenteralna primena; diazepam; stabilnost; reverzna tehnika sa dijaliznim vrećicama.

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By‐Product Utilization

Pickard¹,

Lima²,

Shahidi³

2020

Bailey's Industrial Oil and Fat Products

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This article provides an overview of the by‐products of seed processing and oil refining. The various uses of soybean, canola, sunflower, palm, safflower, cottonseed, olive, coconut, flax, and more are examined along with their extraction processes. The latest improvements in the by‐products of oil refining, such as lecithin, refining by‐product lipid, spent bleaching earth, deodorizer distillate, and spent catalyst are also reviewed.

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Lecithin-based nanoemulsions

Cited by 189 publications

References 154 publications

A full factorial design in the formulation of diazepam parenteral nanoemulsions: Physicochemical characterization and stability evaluation

A full factorial design in the formulation of diazepam parenteral nanoemulsions: Physicochemical characterization and stability evaluation

Diazepam-loaded parenteral nanoemulsions: Physicochemical characterization and in vitro release study

By‐Product Utilization

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