Lead Toxicity, Antioxidant Defense and Environment

Carocci, Alessia; Catalano, Alessia; Lauria, Graziantonio; Sinicropi, Maria Stefania; Genchi, Giuseppe

doi:10.1007/398_2015_5003

Cited by 83 publications

(67 citation statements)

References 84 publications

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“…Metals, such as gold, silver, nickel, titanium, chromium and copper, are ubiquitous in our environment and are widely used in costume jewelry, coins, mobile phone and orthodontic materials [28,[60][61][62]. The orthodontic patients are exposed to a considerable amount of nickel, cobalt, titanium and other metals deriving from alloys.…”

Section: Nickel Allergymentioning

confidence: 99%

“…Since heavy and transition metals (Hg, Pb, As, Cu, Ni and Cr) are no degradable by microorganisms, they accumulate in the environment (soil, water and air) and subsequently contaminate the food chain, generating a risk to human health. Some heavy and transition metals are carcinogenic, teratogenic and endocrine disruptors; some others cause neurological and neurodegenerative diseases and behavioral changes in human beings [28,[60][61][62]. Different physical and chemical methods used for remediation of heavy and transition metal pollution suffer from high cost, alteration of soil properties and disturbance of soil microflora and creation of secondary pollution problems.…”

Section: Nickel Phytoremediation and Phytominingmentioning

confidence: 99%

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Nickel: Human Health and Environmental Toxicology

Genchi

Carocci

Lauria

et al. 2020

IJERPH

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892

383

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Nickel is a transition element extensively distributed in the environment, air, water, and soil. It may derive from natural sources and anthropogenic activity. Although nickel is ubiquitous in the environment, its functional role as a trace element for animals and human beings has not been yet recognized. Environmental pollution from nickel may be due to industry, the use of liquid and solid fuels, as well as municipal and industrial waste. Nickel contact can cause a variety of side effects on human health, such as allergy, cardiovascular and kidney diseases, lung fibrosis, lung and nasal cancer. Although the molecular mechanisms of nickel-induced toxicity are not yet clear, mitochondrial dysfunctions and oxidative stress are thought to have a primary and crucial role in the toxicity of this metal. Recently, researchers, trying to characterize the capability of nickel to induce cancer, have found out that epigenetic alterations induced by nickel exposure can perturb the genome. The purpose of this review is to describe the chemical features of nickel in human beings and the mechanisms of its toxicity. Furthermore, the attention is focused on strategies to remove nickel from the environment, such as phytoremediation and phytomining.

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Section: Nickel Allergymentioning

confidence: 99%

Section: Nickel Phytoremediation and Phytominingmentioning

confidence: 99%

Nickel: Human Health and Environmental Toxicology

Genchi

Carocci

Lauria

et al. 2020

IJERPH

Self Cite

892

383

View full text Add to dashboard Cite

show abstract

“…Work lead exposure is a common cause of lead toxicity in the case of adults with certain occupations deal with production, use, maintenance, recycling and disposal of lead products [1]. Several studies have associated lead exposure with a number of diseases including that of nervous, hematopoietic and reproductive system disease as well as kidney and bone diseases [1][2][3]. Various toxic effects induced by lead in biological systems have been linked to either or both the covalently interaction of lead (Pb 2+ ) with-sulfhydryl (SH) groups of the antioxidant defense system, which normally provide protection against free radical toxicity includes enzymes such as glutathione peroxidase (GPx), glutathione-S-transferase, superoxide dismutase (SOD), and catalase (CAT), and nonenzymatic molecule like glutathione (GSH) or by replacing the zinc ion which acts as an essential cofactor in their catalytic sites and inactivates them [1,4].…”

Section: Introductionmentioning

confidence: 99%

Association between occupational lead exposure and plasma levels of selected oxidative stress related parameters in Jordanian automobile workers

Shraideh¹,

Badran²,

Hunaiti³

et al. 2018

Int J Occup Med Environ Health

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Objectives:To study any possible correlation between blood lead levels and some oxidative stress parameters of selected groups of lead-exposed automobile occupational Jordanian workers. Material and Methods: Blood lead levels were determined for a total of 90 male automobile workers aged within the range of 25-45 years old along with the group of 20 agematched healthy males control. To get an idea about the antioxidant status of controls and lead-exposed workers, and to estimate the oxidative stress caused by exposure to lead, we measured the hydrogen peroxide (H 2 O 2 ) concentration, superoxide dismutase (SOD) activity, lipid peroxidation as malondialdehyde (MDA) and total antioxidant capacity of controls and workers. Results: The study showed that lead levels in the case of workers were approximately 4-5 times as high as in controls 14.5-21 μg×dl -1 vs. 4.3 μg×dl -1, respectively. There was a significant decrease (16-25%) in the level of plasma reduced glutathione and 21-33% decrease in total antioxidant capacity (TAOC) in all worker groups, as compared to controls. The results showed that the concentration of malondialdehyde (MDA) in plasma was higher (120-333%) in the case of workers than controls being the highest in automobile electronics and the lowest -in mechanics. Furthermore, there was 149-221% increase in hydrogen peroxide (H 2 O 2 ) concentration, and 26-38% increase in SOD activity in the case of workers compared to the control group. Conclusions: There is a strong evidence for the associations between occupational lead exposure and various markers of oxidative stress in Jordanian automobile occupational workers. Thus, there is an urgent need to raise awareness and to initiate suitable protection guidelines for workers. Int J Occup Med Environ Health 2018;31(4):517 -525

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“…This in turn has led to manifold rise in the occurrence of free lead in biological systems and the inert environment. [1][2][3] It is also assumed that in the eighteenth and early nineteenth century lead was illegally added to wine both as a sweetener and to make it appear fresh. Its prolonged use was considered to have caused dementia to many Roman emperors.…”

Section: Introductionmentioning

confidence: 99%

Detrimental Effects of Lead on Human Health and Protective Effect by Natural Polyphenols: A Review

Bhattacharjee¹,

Kulkarni²,

Habbu³

et al. 2018

Int. Res. J. Pharm.

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Lead is having wide application in day to day life such as building materials, , and sea fish are also commonly intoxicated by lead. Direct or edible exposure of lead is the very common cause of lead toxicity. Chronic toxicity associated with lead is more hazardous compared to acute toxicity. Young children are especially vulnerable to the harmful effects of lead and can suffer from permanent adverse health effects, particularly affecting the brain and nervous system development. Lead causes longterm toxicity in adults, including increased risk of hypertension and kidney damage. Exposure to high lead in pregnant women levels can cause miscarriage, stillbirth, premature birth, low birth weight and minor malformations. Lead is responsible for generation of free radicals which induces a broad range of physiological, biochemical and behavioral dysfunctions. Lead exposure is having detrimental effects on almost all the major organ system which is a major contributory factor for incremental mortality and morbidity. Beneficial effects of polyphenol in lead induced toxicity have been noticed. The probable reason by which it may show the protection is scavenging of reactive oxygen species, generated by lead. Moreover, it is reported that they are also responsible for detoxification by removal of accumulated heavy metals from major organs.

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Lead Toxicity, Antioxidant Defense and Environment

Cited by 83 publications

References 84 publications

Nickel: Human Health and Environmental Toxicology

Nickel: Human Health and Environmental Toxicology

Association between occupational lead exposure and plasma levels of selected oxidative stress related parameters in Jordanian automobile workers

Detrimental Effects of Lead on Human Health and Protective Effect by Natural Polyphenols: A Review

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