Lead Bone Toxicity in Growing Rats Exposed to Chronic Intermittent Hypoxia

Conti, Maria; Bozzini, Clarisa; Facorro, Graciela; Lee, Ching M.; Mandalunis, Patricia; Piehl, Lidia Leonor; Piñeiro, Adriana; Terrizzi, Antonela Romina; Martínez, María Pilar

doi:10.1007/s00128-012-0753-1

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…Lead causes growth retardation by inhibiting endochondral ossification. Increased bone turnover and reduced mineralization rates combine to decrease bone mineral density and mass, and, in the most severe cases, cause osteoporosis [153][154][155][156][157][158][159][160][161][162][163][164].…”

Section: Leadmentioning

confidence: 99%

Effects of thirty elements on bone metabolism

Dermience

Lognay

Mathieu³

et al. 2015

Journal of Trace Elements in Medicine and Biology

201

152

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Section: Leadmentioning

confidence: 99%

Effects of thirty elements on bone metabolism

Dermience

Lognay

Mathieu³

et al. 2015

Journal of Trace Elements in Medicine and Biology

201

152

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“…Previous research has shown a decrease in maximum and failure moments in rat femurs exposed to lead compared with controls [10,24]. Additionally, published research from our laboratory showed reduced biomechanical properties of the mandibles of rats exposed to lead for 90 days, mainly due to an impaired geometrical distribution of the bone and poorer material properties [42,43]. From a mechanical point of view, bone strength depends mainly on the amount of bone mineral content and the arrangement of the trabeculae [44].…”

Section: Discussionmentioning

confidence: 89%

Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone

et al. 2021

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The objective of the present study was to investigate the effects of chronic lead exposure on the mineral properties of alveolar bone. For this purpose, female Wistar rats (n = 8) were exposed to 1000 ppm lead acetate in drinking water for 90 days, while the control group (n = 5) was treated with sodium acetate. The alveolar bone structure and chemical composition of the dissected mandibles were examined using micro-computed tomography (micro-CT), scanning electron microscopy (SEM), inductively coupled plasma optical emission spectrometry (ICP-OES), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), and X-ray diffraction (XRD) techniques to determine possible alterations in alveolar bone due to lead exposure. In addition, changes in bone mechanical properties were analysed using a three-point bending test. Exposure to lead induced notable changes in bone mineralization and properties, specifically a reduction of the trabecular thickness and bone mineral density. Furthermore, there was a reduction in carbonate content and an increase in bone mineral crystallinity. These changes in bone mineralization could be explained by an alteration in bone turnover due to lead exposure. Three-point bending showed a trend of decreased displacement at failure in the mandibles of lead-exposed rats, which could compromise the mechanical stability and normal development of the dentition.

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“…Therefore, the authors postulated that the inhibitory effect of these ions (Co 2+ and chromium) can only be due to the high concentrations mature osteoclasts were exposed to. In contrast to other toxic metals, like aluminum, chromium, cadmium, and lead, which are able to deposit between matrix and calcification front of bone (Boyce et al, 1982;Krishnan et al, 1990;Stepensky et al, 2003;Conti et al, 2012), Co 2+ does not localize in this area of bone (Stepensky et al, 2003) and hence calcification might not directly be prevented by Co 2+ . Previously, Kechrid et al (2006) reported that if male rats were administrated Co 2+ orally (383 mg kg -1…”

Section: Discussionmentioning

confidence: 93%

Cobalt induces alterations in serum parameters associated with bone metabolism in male adult rat

Moshtaghie¹,

Malekpouri²,

Moshtaghie³

et al. 2014

Turk J Biol

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The intention of this study was to investigate the toxic effect of cobalt on the bone metabolism of rats, including calcium, inorganic phosphorus, and bone-specific alkaline phosphatase of serum during short-and long-term experiments. Rats were injected intraperitoneally (IP) with either 16 mg kg -1 BW of cobalt for 5 and 10 days or 6 mg kg -1 BW for 20 and 40 days. It was found that IP administrations of cobalt could increase all serum parameters associated with bone metabolic processes. The observed effect was greatest for 16 mg kg -1 BW when used for 10 continuous days. By using gel filtration chromatography, we found that most of the activity of total serum alkaline phosphatase was related to low molecular weight isoenzymes, which can be used as a biomarker for bone metabolic disturbances. These results suggest that cobalt can induce bone resorption in adult rats and, therefore, behave as an osteoporotic agent.

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Lead Bone Toxicity in Growing Rats Exposed to Chronic Intermittent Hypoxia

Cited by 7 publications

References 14 publications

Effects of thirty elements on bone metabolism

Effects of thirty elements on bone metabolism

Chronic Lead Exposure Alters Mineral Properties in Alveolar Bone

Cobalt induces alterations in serum parameters associated with bone metabolism in male adult rat

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