1974
DOI: 10.1289/ehp.747113
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Abstract: Lead acetate was administered continuously in the drinking water to CD-1 male mice beginning at 4 weeks of age. An LD,o02o of the lytic viruses or 300 plaque-forming units of RLV was inoculated intrapertioneally at 6 weeks of age. Lead increased the response of the mice to all classes of viruses against which it was tested: an RNA picornavirusencephalomyocarditis (EMCV), a DNA herpesvirus-pseudoribies, an RNA leukemiavirus-Rauscher leukemia (RLV), an RNA arbovirus B-St. Louis encephalitis, and an RNA arbovirus… Show more

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Cited by 48 publications
(5 citation statements)
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“…Immunosuppression of the host can result in chronic HBV infections. Lead and cadmium are hepatotoxic [ 38 , 39 ] and have been shown to increase viral activity [ 31 , 40 ]. In addition, dietary cadmium has been shown to enhance the progression of hepatocellular tumors in HBV-infected mice [ 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…Immunosuppression of the host can result in chronic HBV infections. Lead and cadmium are hepatotoxic [ 38 , 39 ] and have been shown to increase viral activity [ 31 , 40 ]. In addition, dietary cadmium has been shown to enhance the progression of hepatocellular tumors in HBV-infected mice [ 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…Whilst in certain enzymic processes such mechanisms are important initiators, their effect on other molecules can be detrimental. Such an impairment of activity was observed in antibody (Williams et al, 1954;Jones et al, 1971), complement (Hemphill et al,197 I), and interferon (Gainer, 1974), which had been exposed to lead or cadmium. The general metabolic processes of fish are affected by heavy metal exposure, and this would be expected to affect growth (Christensen, 1975), as was observed in the trout and carp exposed to copper and chromium.…”
Section: Discussionmentioning
confidence: 99%
“…In vivo research has shown that Pb is immunotoxic and causes depression of humoral immunity [ 85 ], increasing host’s susceptibility to bacterial and viral infections [ 86 , 87 ]. In addition, although many studies have also shown that Pb affects the functioning of different types of cells, including immune system cells, the mechanism of this effect is not fully understood.…”
Section: Influence Of Pb On Immune System Cellsmentioning
confidence: 99%