Le cancer du sein chez l’homme : approche épidémiologique, diagnostique, et thérapeutique : étude multicentrique rétrospective à propos de 95 cas

Oger, A; Boukerrou, Malik; Cutuli, B.; Campion, Loı̈c; Rousseau, E.; Bussières, E; Raro, Pédro; Classe, Jean‐Marc

doi:10.1016/j.gyobfe.2015.02.010

Cited by 15 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Malignant tumors were exclusively represented by infiltrating ductal carcinomas according to several authors [6] [15]. The average age of onset was similar to other authors [16] [17] [18]. But, they are of worse prognosis than in the woman because of the delayed diagnosis.…”

Section: Histopathological Aspects Of Nodulessupporting

confidence: 65%

Male Breast Nodules in Ouagadougou (Burkina Faso): Radiological and Histopathological Aspects

Ouedraogo¹,

Napon²,

Tiemtore³

et al. 2018

OJRad

View full text Add to dashboard Cite

Objective: To describe the radiological and histological aspects of breast nodules among men in our practice setting. Methodology: This is a descriptive and retrospective study conducted from January 2014 to October 2017. The study included male patients with breast nodules classified ACR3, 4 or 5 after a mammographic and ultrasound scan. These lesions were explored through an ultrasound-guided breast microbiopsy. The following are the variables collected: age, family history of breast cancer, medical history, ACR classification, nodule size, and anatomopathologic diagnosis. Results: 13 breast nodules were explored among 13 male subjects. Mammography and breast ultrasound enabled to identify one ACR3 lesion, 10 ACR4 lesions and 2 ACR5 lesions. The average age was 56.53 ± 14.63 years and the average size of the nodules 28.91 ± 13.62 mm. As for histology, there were seven malignant tumors and six benign tumors. The average age of patients with malignancy was 61.45 ± 13.62 years. The malignant nodules average size was 29.45 ± 12.54 mm. Malignant tumors exclusively consisted of invasive breast carcinomas while Benign ones consisted of dystrophic and inflammatory lesions. Conclusion: Most often Breast lesions among men had an indeterminate appearance on imaging and were predominantly malignant in histopathology.

show abstract

Section: Histopathological Aspects Of Nodulessupporting

confidence: 65%

Male Breast Nodules in Ouagadougou (Burkina Faso): Radiological and Histopathological Aspects

Ouedraogo¹,

Napon²,

Tiemtore³

et al. 2018

OJRad

View full text Add to dashboard Cite

show abstract

“…Our model consisted of eight independent prognostic indicators such as age, marital status, T stage, N stage, M stage, PR, HER2, and chemotherapy. Age has been revealed as a critical prognostic indicator for OS in several studies (Brinton et al, 2014; Oger et al, 2015). Consistently, we found that patients over 70 years harbor a lower OS than the younger patients.…”

Section: Discussionmentioning

confidence: 99%

A prognostic nomogram for overall survival in male breast cancer with histology of infiltrating duct carcinoma after surgery

Chai¹,

Sun²,

Jia

et al. 2019

PeerJ

View full text Add to dashboard Cite

Objective The study was designed to construct and validate a nomogram for predicting overall survival (OS) of male breast cancer (MBC) patients with infiltrating duct carcinoma (IDC). Methods The cohort was selected from the Surveillance, Epidemiology, and End Results (SEER) database between January 1, 2004 and December 31, 2013. Univariate and multivariate Cox proportional hazard (PH) regression models were performed. A nomogram was developed based on the significant prognostic indicators of OS. The discriminatory and predictive capacities of nomogram were assessed by Harrell’s concordance index (C-index), calibration plots, area under the curve (AUC) and the decision curve analysis (DCA). Results The median and maximal survival time of 1862 eligible patients were 49 and 131 months, respectively. Multivariate analysis showed that age (P < 0.0001), marital status (P = 0.002), T stage (P < 0.0001), N stage (P = 0.021), M stage (P < 0.0001), progesterone receptor (PR) (P = 0.046), human epidermal growth factor receptor-2 (HER2) (P = 0.009), and chemotherapy (P = 0.003) were independent prognostic indicators of IDC of MBC. The eight variables were then combined to construct a 3-and 5-year nomogram. The C-indexes of the nomogram were0.740 (95% confidence interval [CI] [0.709–0.771]) and 0.718 (95% CI [0.672–0.764]) for the internal validation and external validation, respectively. A better discriminatory capacity was observed in the nomogram compared with the SEER summary stage (P < 0.001) and AJCC TNM staging systems (6th edition; P < 0.001) with respect to OS prediction. Good consistency was detected between the nomogram prediction and actual findings, as indicated by calibration curves. The AUC for 3-and 5-year OS was 0.739 (95% CI [0.693–0.786]) and 0.764 (95% CI [0.725–0.803]) in the training cohort and 0.737 (95% CI [0.671–0.803]) and 0.735 (95% CI [0.678–0.793]) in the validation cohort, respectively. The DCA demonstrated that the survival nomogram was clinically useful. Conclusions The nomogram was able to more accurately predict 3-and 5-year OS of MBC patients with IDC histology than were existing models.

show abstract

“…The diagnosis is often made at later stages, and the tumor size is usually bigger. [15] Age has been accepted as a risk factor that guides unfavorable prognosis. Another unfavorable prognostic factor for OBC is bad axillary lymph node status.…”

Section: Discussionmentioning

confidence: 99%

Axillary lymph node metastasis as the first manifestation of male occult breast cancer

Wang

Fan²,

Yan³

et al. 2018

Medicine

View full text Add to dashboard Cite

Rational:Occult breast cancer (OBC) is an extremely rare breast cancer and is defined by the presence of axillary metastasis without a primary tumor in the breasts or any abnormality on radiologic examination.Patient concerns:This case report presents a 49-year-old man who was diagnosed with male OBC, which first manifested as an axillary lymph node metastasis followed by the emergence of infraclavicular lymph node metastasis. Neither the breast nor other organs had any abnormality.Diagnosis:The pathological examination revealed metastatic adenocarcinoma. Immunohistochemical (IHC) staining results were positive for estrogen receptor (ER), progesterone receptor (PR), and gross cystic disease fluid protein-15 (GCDFP-15); and negative for human epidermal receptor-2 (Her-2) 1+, cytokeratin (CK) 7, CK20, and thyroid transcription factor-1 (TTF-1).Interventions:The patient underwent left axillary lymph node dissection but not a mastectomy. After the operation, the patient subsequently underwent chemotherapy, radiotherapy, and endocrinotherapy.Outcomes:Currently, he has been followed-up for >4 years without any signs of recurrence.Lessons:Careful physical and imaging examinations combined with pathological analysis are essential in the diagnosis of male OBC. Early surgery remains the primary treatment.

show abstract

Le cancer du sein chez l’homme : approche épidémiologique, diagnostique, et thérapeutique : étude multicentrique rétrospective à propos de 95 cas

Cited by 15 publications

References 34 publications

Male Breast Nodules in Ouagadougou (Burkina Faso): Radiological and Histopathological Aspects

Male Breast Nodules in Ouagadougou (Burkina Faso): Radiological and Histopathological Aspects

A prognostic nomogram for overall survival in male breast cancer with histology of infiltrating duct carcinoma after surgery

Axillary lymph node metastasis as the first manifestation of male occult breast cancer

Contact Info

Product

Resources

About