Le cancer du sein chez la femme de 30 ans et moins

Bakkali, H.; Marchal, C.; Lesur-Schwander, A; Verhaeghe, Jean-Luc

doi:10.1016/s1278-3218(03)00021-0

Cited by 19 publications

(15 citation statements)

References 26 publications

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“…Similar to other studies, the most frequent histological type of breast cancer in young women was infiltrating ductal carcinoma. 20 – 22 In the current study, its incidence was 81%; however, it was 95% in an analytical Tunisian retrospective survey among women with breast cancer younger than 35 years. 23…”

Section: Discussioncontrasting

confidence: 58%

Breast cancer characteristics in very young Egyptian women ≤35 years

Farouk¹,

Ebrahim²,

Senbel³

et al. 2016

BCTT

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BackgroundBreast cancer in very young patients represents a unique issue that needs more attention as the number of cases is increasing and it has special characteristics at presentation, diagnosis, and biologic behaviors which reflect on both treatment strategies and survival. The aim of the current study was to analyze and report the clinico-pathological characteristics and treatment procedures used for breast cancer in very young patients over the last decade in a single Egyptian cancer center.Patients and methodsA retrospective study was conducted in the Oncology Center – Mansoura University, where the data of all breast cancer patients, between September 2006 and August 2015, were reviewed. Among 4,628 patients who were diagnosed with breast cancer during this period, only 300 patients aged ≤35 years had complete registry data. Clinico-pathological characteristics, therapeutic procedures, and survival outcome were reported.ResultsThree hundred and seventy-nine patients (8.19%) were aged ≤35 years at the time of presentation. The age ranged between 21 and 35 years, and the mean age was 31 years (±3 standard deviation). Positive family history of breast cancer was found in 12.3%, and metastatic presentation was seen in 4.7%. The rate of axillary lymph nodes involvement was 75.7%. The estrogen receptor-negative disease was found in 51%, and among 217 patients who did HER2 test, 82 patients (37.8%) were HER2 positive, while triple-negative subtype was found in 57 patients (26.4%). Ki 67 percentage ranged between 3% and 66% (median was 35%). The median disease-free survival was 61 months (95% confidence interval 44–78 months); the 3-year and 5-year disease-free survival were 58% and 50%, respectively. The 3-year and 5-year overall survival were 88% and 68%, respectively.ConclusionVery young Egyptian patients with breast cancer should be given focus and specially studied as the presentation has more aggressive biologic behavior at advanced stages, so the treatment strategies have to be tailored in a very precise manner.

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Section: Discussioncontrasting

confidence: 58%

Breast cancer characteristics in very young Egyptian women ≤35 years

Farouk¹,

Ebrahim²,

Senbel³

et al. 2016

BCTT

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“…Similarly to other studies, the most frequent histological type of breast cancer in young women was ductal carcinoma [31,34,35]. Bouzid et al (2013) [17], in an analytical retrospective survey conducted in Tunisia with breast cancer women younger than 35, identified that the infiltrating ductal carcinoma was present in 95% of cases.…”

Section: Discussionsupporting

confidence: 64%

Breast Cancer in Young Brazilian Women: Challenge for the Oncology Care

Gravena

Agnolo

Lopes

et al. 2014

Epidemiology Research International

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Objective. To investigate and compare aspects of breast cancer in young women (<40 years old) with older women (>40 years old). Methods. Retrospective, cross-sectional, analytical, and exploratory study based on data from 2009 to 2012 obtained from the Breast Cancer Information System (SISMAMA) and the Unified Health System Information Data (DATASUS). The studied population consisted of women (n=31.195) with malignant breast cancer. The analysed variables were education level, race, nodule detection at the clinical examination or image studies, presence of palpable axillary lymph nodes, surgical approach, and tumor histological type and grade. Results. There was increasing detection of breast cancer cases in young women among the studied years. Young women had more palpable lymph nodes (OR 1.28, 95% CI: 1.18–1.39), ductal carcinoma as the most frequent histologic type (OR 1.36, 95% CI: 1.22 to 1.53), and grades II and III tumor (OR 16.01 , 95% CI: 13.30 to 19.28 ). The lesion detection by clinical examination was higher in women <40 years (OR 1.34, 95% CI: 1.24 to 1.45). Conclusion. Although there are early detection measures related to breast cancer, they are not the usual practice of the young female public, suggesting the need for a review of existing public policies in the country.

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“…La nulliparité est considérée comme un facteur de risque ; notre proportion de 12,86 % ne diffère pas de celle de Bakhali et al [9] qui trouvaient sur 30 malades 26,70 % de nullipare avec p = 0,08, et de celle de Barnett et al [2] qui trouvaient sur un effectif de 4 127 patients 15 % de nullipare avec p = 0,39.…”

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“…Ce fait est surtout observé dans les séries françaises et tunisiennes [9,14] où le stade I + II est représenté dans 73 à 74 %, contrairement à nos séries maliennes où les plus fortes proportions sont retrouvées dans le stade III + IV, variant de 61,6 à 86,6 %.…”

Section: Stadificationunclassified

Cancer du sein dans deux centres hospitaliers de Bamako (Mali): aspects diagnostiques et thérapeutiques

Togo¹,

Traoré²,

Traoré

et al. 2010

J Afr Cancer

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But : Décrire les aspects diagnostiques et thérapeu-tiques du cancer du sein. Méthodologie : C'est une étude rétrospective (mars 1999-juillet 2008) dans deux hôpitaux de Bamako au Mali. L'examen histologique a été effectué chez tous les malades. Résultats : Nous avons colligé 210 malades (205 femmes et cinq hommes) avec un âge moyen de 47,4 ans. Cinquantesept (27,14 %) malades avaient un antécédent de pathologie bénigne du sein ; chez 47 patients, le cancer du sein dans la famille a été retrouvé. La prise d'estroprogestatifs a été évo-quée par 59 patientes. Nous avons retrouvé 32 métastases osseuses, 56 pulmonaires et 43 métastases hépatiques. Nous avons effectué 138 mastectomies avec curage ganglionnaire selon Patey contre 21 cas de chirurgie conservatrice. La morbidité postopératoire a été de 13,81 %. L'examen histologique a révélé un cancer canalaire infiltrant chez 120 (57,14 %) malades et un carcinome lobulaire infiltrant chez 45 (21,43 %) malades. Cinquante-six (26,67 %) malades étaient de stade TNM I + II, 122 (58,10 %) malades étaient positifs au récepteur estrogénique (RE). Cent quatorze (54,86 %) malades ont bénéficié d'une hormonothérapie ou chimiothérapie, nous n'avons pas fait de radiothérapie. Dans le groupe des 97 malades qui avaient un recul de cinq ans, la survie à cinq ans a été de 37,1 %. Conclusion : Le pronostic du cancer du sein est grave au Mali. Mots clés Cancer · Sein · MaliAbstract Aim: To describe clinical and therapeutic aspects of breast cancer. Methodology: We made a retrospective study (March 1999-July 2008 in two hospitals of Bamako (Mali). The histological examination was done in all the cases. Results: We selected 210 patients (205 women and 5 men); the mean age was 47.4 ± 13.6 years and the extremes of 21 and 82 years. Fifty-seven women (27.14%) had antecedents of benign pathology of breast. Breast cancer occurred in a family member in 47 patients. The administration of estroprogestatives for contraception was found in 59 patients. We found 32 cases of bone metastases, 56 cases of pulmonary metastases, and 43 cases of hepatic metastases. We carried out 138 mastectomies with lymphadenectomy (Patey) and 21 quadrantectomies with lymphadenectomy. The morbidity after surgery (abscess of partition lymphoedeme) was 13.81% (29 cases). The histological examination revealed an infiltrating canal cancer in 120 cases (57.14%) and an infiltrating lobular carcinoma in 45 cases (21.43%). We classified 56 patients (26.67%) under stage TNM I + II, 122 patients (58.10%) were estrogen receivers positive. One hundred fourteen patients (54.86%) have benefited of chemotherapy or hormonotherapy but any radiotherapy. In the group of 97 patients who had a long-term follow-up, survival at 5 years was of 37.1%. Conclusion: The prognostic of breast cancer is serious in Mali.

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Le cancer du sein chez la femme de 30 ans et moins

Cited by 19 publications

References 26 publications

Breast cancer characteristics in very young Egyptian women ≤35 years

Breast cancer characteristics in very young Egyptian women ≤35 years

Breast Cancer in Young Brazilian Women: Challenge for the Oncology Care

Cancer du sein dans deux centres hospitaliers de Bamako (Mali): aspects diagnostiques et thérapeutiques

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Le cancer du sein chez la femme de 30 ans et moins

Cited by 19 publications

References 26 publications

Breast cancer characteristics in very young Egyptian women &le;35 years

Breast cancer characteristics in very young Egyptian women &le;35 years

Breast Cancer in Young Brazilian Women: Challenge for the Oncology Care

Cancer du sein dans deux centres hospitaliers de Bamako (Mali): aspects diagnostiques et thérapeutiques

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Breast cancer characteristics in very young Egyptian women ≤35 years

Breast cancer characteristics in very young Egyptian women ≤35 years