LC-MS/MS-based method for simultaneous quantification of known chemicals and metabolites of Alpiniae oxyphyllae Fructus extract in rat plasma and its application in a pharmacokinetic study

Qi, Wen; Li, Hai Long; Tan, Yin Feng; Zhang, Xu Guang; Qin, Zhen; Li, Wei; Li, Yong Hui; Zhang, Jun Qing; Chen, Feng

doi:10.1039/c5ay03389f

Cited by 14 publications

(7 citation statements)

References 31 publications

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“…Another study also reported that a plasma concentration as low as 60 μg L –1 nootkatone was detected 5 min after intragastric administration of 50 mg kg –1 nootkatone to rats . Furthermore, other studies indicated the rapid absorption and elimination of nootkatone. , After intravenous administration (2 mg kg –1 ), nootkatone showed poor bioavailability, and the maximum plasma concentration ( C max ) value was 890.33 ng mL –1 and the half-life ( t 1/2 ) value was 1.36 h …”

Section: Parmacokinetic Propertiesmentioning

confidence: 99%

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Zhang

Chen

et al. 2022

J. Agric. Food Chem.

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Valencene and nootkatone, two sesquiterpenes, extracted from natural sources, have great market potential with diverse applications. This paper aims to comprehensively review the recent advances in valencene and nootkatone, including source, production, physicochemical and biological properties, safety and pharmacokinetics evaluation, potential uses, and their industrial applications as well as future research directions. Microbial biosynthesis offers a promising alternative approach for sustainable production of valencene and nootkatone. Both compounds exert various beneficial activities, including antimicrobial, insecticidal, antioxidant, anti-inflammatory, anticancer, cardioprotective, neuroprotective, hepatoprotective, and nephroprotective and other activities. However, most of the studies are performed in animals and in vitro, making it difficult to give a conclusive description about their health benefits and extend their application. Hence, more attention should be paid to in vivo and long-term clinical studies in the future. Moreover, valencene and nootkatone are considered safe for consumption and show great promise in the applications of food, cosmetic, pharmaceutical, chemical, and agricultural industries.

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Section: Parmacokinetic Propertiesmentioning

confidence: 99%

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Zhang

Chen

et al. 2022

J. Agric. Food Chem.

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“…In the case of GL-V9, although a concentration peak was seen after 0.5 h of oral administration, a second twin peak was recorded after 12 h (in rats), most likely related to the enterohepatic, enteric, or local recycling [60]. A double peak was detected in the plasma concentration–time curves for baicalin, oroxin A (baicalein-7- O -glucoside), baicalein, wogonoside, wogonin, and chrysin when administered in rats, related to enterohepatic, local, or enteric recycling [16,23,32,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100]. In one study in rats, it was claimed that this bi-modal “behavior” was not confirmed experimentally [101], but the authors only measured plasma samples up to 180 min, whereas in order to observe the second peak (at its maximum) at least 6–8 h would often be needed [102,103,104,105], although in other cases a second peak was reported after only two to three hours [106,107,108,109]; in dogs, following i.v.…”

Section: Recyclingmentioning

confidence: 99%

Pharmacokinetics of B-Ring Unsubstituted Flavones

et al. 2019

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B-ring unsubstituted flavones (of which the most widely known are chrysin, baicalein, wogonin, and oroxylin A) are 2-phenylchromen-4-one molecules of which the B-ring is devoid of any hydroxy, methoxy, or other substituent. They may be found naturally in a number of herbal products used for therapeutic purposes, and several have been designed by researchers and obtained in the laboratory. They have generated interest in the scientific community for their potential use in a variety of pathologies, and understanding their pharmacokinetics is important for a grasp of their optimal use. Based on a comprehensive survey of the relevant literature, this paper examines their absorption (with deglycosylation as a preliminary step) and their fate in the body, from metabolism to excretion. Differences among species (inter-individual) and within the same species (intra-individual) variability have been examined based on the available data, and finally, knowledge gaps and directions of future research are discussed.

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“…In general, low concentrations of an electrolyte modifier, such as formic acid and ammonium acetate, added into the mobile phase have minimal negative effect on the signal intensity and absolute matrix effects of the analytes (Li et al, 2012;Li, Liang, F, & Li, 2007). It was reported that 0.1‰ formic acid in the mobile phase can increase the ESI response of yakuchinone A and can overcome the matrix effects to some extent (Wen et al, 2016). The matrix effects and extraction recovery of DPHB and yakuchinone A from the present study are summarized in Table 2.…”

Section: Matrix Effect and Recoverymentioning

confidence: 99%

Development and validation of an LC–MS/MS method for the determination of DPHB in rat plasma and its application in pharmacokinetic studies

Chen

et al. 2018

Biomedical Chromatography

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The aim of the present study was to develop a rapid, specific and sensitive LC-MS/MS method for the determination of DPHB [7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-4-hepten-3-one] in rat plasma using yakuchinone A as an internal standard (IS). n-Hexane was used for the extraction of DPHB from rat plasma. Chromatographic separation of DPHB was achieved using a Kinetex XB-C column (2.10 × 50 mm, 2.6 μm) at 40°C. The mobile phase consisted of water (containing 0.1‰ formic acid, A) and acetonitrile (containing 0.1‰ formic acid, B) under a gradient elution at a flow rate of 0.3 mL min . Positive electrospray ionization and multiple reaction monitoring mode were used for detection. The selected precursor ion to product ion pairs, m/z 311.3 → 137.0 for DPHB and m/z 313.1 → 137.0 for yakuchinone A, were monitored. Good linearity was observed over the concentration range from 2 to 2000 ng mL (r = 0.9969). The recovery efficiency of DPHB from rat plasma was 54.8-69.7%, while the matrix effect ranged from 99.7 to 113%. Intra- and inter-day precision and accuracy values were within ±15% at three different quality control concentration levels. This validated method was successfully applied to pharmacokinetic studies in rats after a single p.o. or i.v. dose of DPHB solution. The route of administration significantly influenced systemic exposure to DPHB, and low bioavailability of DPHB was observed. The method developed here will be further improved and used in future pharmacokinetic studies.

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LC-MS/MS-based method for simultaneous quantification of known chemicals and metabolites of Alpiniae oxyphyllae Fructus extract in rat plasma and its application in a pharmacokinetic study

Abstract: An LC-MS-based method for the quantification of Alpinia oxyphyllae fruit extract components in rat plasma and its application in a pharmacokinetic study.

Cited by 14 publications

References 31 publications

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Pharmacokinetics of B-Ring Unsubstituted Flavones

Development and validation of an LC–MS/MS method for the determination of DPHB in rat plasma and its application in pharmacokinetic studies

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