Layer-by-layer development of chitosan/alginate-based platelet-mimicking nanocapsules for augmenting doxorubicin cytotoxicity against breast cancer

Ibrahim, Alaa; Khalil, Islam A.; Mahmoud, Mohamed Y.; Bakr, Alaa F.; Ghoniem, Monira G.; Al‐Farraj, Eida S.; El‐Sherbiny, Ibrahim M.

doi:10.1016/j.ijbiomac.2022.11.107

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…CS exhibited peaks at 1156 cm −1 (C–N stretching) and 1653 cm −1 (amide I) [ 2 ]. Alg powder peaks were observed at 1616 and 1419 cm −1 , corresponding to the carboxylic group (–COO − ) [ 23 ]. For unmodified HA, peaks are typically present at 1666 and 1659 cm −1 , corresponding to the C–N stretching of amide I and II, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The amino and hydroxyl groups of CS can form bonds via electrostatic interactions with the negatively charged groups of other materials. For example, the –NH 3 + group of CS interacts with the –COO − group of Alg to form bilayer or multilayer films via the LBL technique [ 22 , 23 , 24 ]. In 2012, Gomes et al successfully prepared an CS/Alg multilayer membrane on cotton gauze using the LBL method [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Cytotoxicity of Hyaluronic Acid/Chitosan/Bacterial Cellulose-Based Membrane

et al. 2023

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Novel wound dressing materials are required to non-cytotoxic with a viable cell ratio of above 92%. Herein, the cytotoxicity of hyaluronic acid/chitosan/bacterial cellulose-based (BC(CS/HA)) membranes are evaluated and compared to that of alginate/chitosan/bacterial cellulose-based (BC(CS/Alg)) membranes was investigated. Multilayer membranes with up to ten CS/HA or CS/Alg layers were prepared using the layer-by-layer (LBL) method. Scanning electron microscopy showed that the diameters of the fibers in the BC(CS/Alg) and BC(CS/HA) membranes were larger than those in a BC membrane. The cytotoxicity was analyzed using BALB-3T3 clone A31 cells (mouse fibroblasts, 1 × 104 cells/well). The BC(CS/HA)5 and BC(CS/HA)10 membranes exhibited high biocompatibility, with the cell viabilities of 94% and 87% at 5 d, respectively, compared to just 82% for the BC(CS/Alg)5 and BC(CS/Alg)10 membranes with same numbers of layers. These results suggested that BC(CS/HA)5 is a promising material for wound dressings.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Cytotoxicity of Hyaluronic Acid/Chitosan/Bacterial Cellulose-Based Membrane

et al. 2023

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“…In the past, several therapeutic drugs have been used to treat cancer patients, among which doxorubicin (DOX) is a very effective drug against cancer cells [ 27 ]. DOX is capable of controlling various cancers, like gastric cancer, breast cancer, and bladder cancer [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Imran,

Tang,

Wang

et al. 2023

Molecules

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Chitosan nanoparticles (NPs) serve as useful multidrug delivery carriers in cancer chemotherapy. Chitosan has considerable potential in drug delivery systems (DDSs) for targeting tumor cells. Doxorubicin (DOX) has limited application due to its resistance and lack of specificity. Chitosan NPs have been used for DOX delivery because of their biocompatibility, biodegradability, drug encapsulation efficiency, and target specificity. In this review, various types of chitosan derivatives are discussed in DDSs to enhance the effectiveness of cancer treatments. Modified chitosan–DOX NP drug deliveries with other compounds also increase the penetration and efficiency of DOX against tumor cells. We also highlight the endogenous stimuli (pH, redox, enzyme) and exogenous stimuli (light, magnetic, ultrasound), and their positive effect on DOX drug delivery via chitosan NPs. Our study sheds light on the importance of chitosan NPs for DOX drug delivery in cancer treatment and may inspire the development of more effective approaches for cancer chemotherapy.

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Chitosan-functionalized bioplatforms and hydrogels in breast cancer: immunotherapy, phototherapy and clinical perspectives

Li,

Ashrafizadeh,

Shang

et al. 2024

Drug Discovery Today

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Layer-by-layer development of chitosan/alginate-based platelet-mimicking nanocapsules for augmenting doxorubicin cytotoxicity against breast cancer

Cited by 5 publications

References 38 publications

Evaluation of Cytotoxicity of Hyaluronic Acid/Chitosan/Bacterial Cellulose-Based Membrane

Evaluation of Cytotoxicity of Hyaluronic Acid/Chitosan/Bacterial Cellulose-Based Membrane

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Chitosan-functionalized bioplatforms and hydrogels in breast cancer: immunotherapy, phototherapy and clinical perspectives

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