Latex‐allergic children

Frankland, A. W.

doi:10.1034/j.1399-3038.1999.00041.x

Cited by 14 publications

(7 citation statements)

References 56 publications

(58 reference statements)

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“…Natural rubber latex antigens from the rubber tree ( Hevea brasiliensis (Frankland 1999)) are important sensitizers in health care workers, due to use of latex gloves, and in children with spina bifida, due to multiple surgeries that cause contact with rubber (Frankland 1999; Poley & Slater 2000). Thus, latex allergy can occur from direct contact with latex‐containing products, but aerosol transmission of antigen has also been well documented (Poley & Slater 2000) and thus constitutes a special problem in operating theatres (Frankland 1999). The immediate hypersensitivity to rubber latex is an IgE‐mediated reaction to the numerous allergens in latex.…”

Section: Clinically Important Aeroallergensmentioning

confidence: 99%

IgE‐Mediated Asthma and Rhinitis I: A Role of Allergen Exposure?

Nielsen¹,

Hansen²,

Lund³

et al. 2002

Pharmacology & Toxicology

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Exposures to airborne protein antigens, aeroallergens, may cause sensitization with production of Th2-dependent antibodies, including IgE. The IgE antibodies and associated cellular responses are responsible for the allergic airway diseases, allergic rhinitis and allergic asthma, which are increasing in societies with Western life style. Aeroallergens may have different potential to sensitize exposed subjects. Thus, there are only a limited number of important groups of aeroallergens, which are those from house dust mites, cockroaches, pets, pollens, and moulds. Allergy follows to a certain extent the pharmacological/toxicological paradigm of dose-response relationship. Unlike effects of pharmacologically and toxicologically active substances, allergens elicit their adverse effects in a two-stage process. In the first stage the immunologically naïve individual is sensitized to the allergen. In the second stage renewed exposure to the allergen elicits the disease response. Also, high concentrations of aeroallergens may induce immunological tolerance. The scientific literature suggests that many environmental factors contribute to the increase in sensitization and development of airway allergies. Nevertheless, the dose-response relationships apply (within certain limits) both to the sensitization itself and to the exacerbation of the diseases. This suggest that exposure reduction may be one of the methods for reduction of risk, in relation to control of the allergic airway diseases.

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Section: Clinically Important Aeroallergensmentioning

confidence: 99%

IgE‐Mediated Asthma and Rhinitis I: A Role of Allergen Exposure?

Nielsen¹,

Hansen²,

Lund³

et al. 2002

Pharmacology & Toxicology

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“…Spina bifida patients are frequently exposed to latex as they are in contact with latex products very early in life (gloves, catheters) and undergo multiple surgical procedures from an early age. A high latex allergy prevalence of 29–64% had been found in Spina Bifida studies in the USA and Europe (6–11). The prevalence reported in one European country, Italy was substantially lower at 15% (12), while a study from Venezuela put the figure at only 4% (13).…”

mentioning

confidence: 99%

Low prevalence of latex sensitivity in South African spina bifida children in Cape Town

Johar

Lim

Arif

et al. 2005

Pediatric Allergy Immunology

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Spina bifida children have a high prevalence of latex allergy in studies reported from Europe and the USA. This study investigated the prevalence of latex allergy in a cohort of 24 spina bifida children at the Red Cross Children's Hospital from Cape Town, South Africa. The children were investigated using a detailed questionnaire, skin prick tests (ALK-Abello), ImmunoCap RASTs, Western blotting and ELISA, using the purified latex proteins Hev b1 and Hev b3 and whole latex preparation. A low overall prevalence of latex sensitization of 16.7% was found in the children. Children who were sensitive reacted to water insoluble to Hev b1 and Hev b3 proteins. The low prevalence of latex sensitization in the South African children may not be entirely explained by stringent latex avoidance. The children were from a low socioeconomic social status and 'hygiene' and other factors should be considered.

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“…This latter mechanis is secondary to products derivated of cornflour, with low molecular weight, recently introducted as part of the inner powder in several trades of latex gloves; these products link gentle to latex particles, releasing them into the air. It has been demonstrated that, like happens in children with spina bifida, the more the number of surgical operations, the more the probabilities of become sensitized 2 .…”

Section: Discussionmentioning

confidence: 99%

Erythema multiforme-like eruption due to carbamates and thiuram

Leis-Dosil

Campos‐Domínguez

Zamberk-Majlis

et al. 2006

Allergologia et Immunopathologia

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Report of a case of erythema multiforme-like eruption due to the use of rubber gloves. After several complementary studies, including epicutaneous and skin prick tests, we concluded that the eruption was secondary to sensitization to carbamates and thiuram. The main differential diagnosis in this case was allergic contact dermatitis to latex in natural rubber gloves. This entity is less frequent than might be expected, because it is usually due to intermediate chemical compounds used in rubber manufacturing, such as vulcanization accelerators; among of these latter compounds are thiurams and carbamates. Erythema multiforme-like eruption is a rare manifestation of contact dermatitis. Several cases have been reported, most of which have been due to contact with plants, metals or topical non-steroidal anti-inflammatory drugs. Its mechanism is still unclear, but it seems to be a type IV hypersensitivity reaction.

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Latex‐allergic children

Cited by 14 publications

References 56 publications

IgE‐Mediated Asthma and Rhinitis I: A Role of Allergen Exposure?

IgE‐Mediated Asthma and Rhinitis I: A Role of Allergen Exposure?

Low prevalence of latex sensitivity in South African spina bifida children in Cape Town

Erythema multiforme-like eruption due to carbamates and thiuram

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