Lateralization of the serotonin-1A receptor distribution in language areas revealed by PET

Fink, Martin; Wadsak, Wolfgang; Savli, Markus; Stein, P.; Moser, Ulrike; Hahn, Andreas; Mien, Leonhard‐Key; Kletter, Kurt; Mitterhauser, Markus; Kasper, Siegfried; Lanzenberger, Rupert

doi:10.1016/j.neuroimage.2008.11.033

Cited by 70 publications

(50 citation statements)

References 72 publications

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“…The few instances in which uncoupling between hemodynamic and neuronal metabolism have been demonstrated involved cases of extreme pathology, such as cerebrovascular disease, increased intracranial pressure, or stroke 12 . If these findings do represent a hormonal modulation of neuronal activity, we should expect our findings to be consistent with asymmetric behavior patterns associated with modulation of cholinergic, serotonergic, noradrenergic, dopaminergic and GABA systems by ovarian steroids [22][23][24][25] . It has been shown that young women express relatively greater resting right frontal activity during the periovulatory phase compared to the menstrual phase 26 .…”

Section: Discussionsupporting

confidence: 57%

Cerebrovascular Reactivity across the Menstrual Cycle in Young Healthy Women

et al. 2013

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Section: Discussionsupporting

confidence: 57%

Cerebrovascular Reactivity across the Menstrual Cycle in Young Healthy Women

et al. 2013

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“…Twenty-eight healthy subjects participated in this study (mean age ± SD = 26.5 ± 6.8 y, 17 female), who in part also served as control subjects in previous studies (57,(70)(71)(72)(73) (SI Materials and Methods). This project was approved by the Ethics Committee of the Medical University of Vienna and the General Hospital of Vienna.…”

Section: Methodsmentioning

confidence: 99%

Differential modulation of the default mode network via serotonin-1A receptors

Hahn

Wadsak

Windischberger

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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112

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Reflecting one's mental self is a fundamental process for evaluating the personal relevance of life events and for moral decision making and future envisioning. Although the corresponding network has been receiving growing attention, the driving neurochemical mechanisms of the default mode network (DMN) remain unknown. Here we combined positron emission tomography and functional magnetic resonance imaging to investigate modulations of the DMN via serotonin-1A receptors (5-HT 1A ), separated for 5-HT autoinhibition (dorsal raphe nucleus) and local inhibition (heteroreceptors in projection areas). Using two independent approaches, regional 5-HT 1A binding consistently predicted DMN activity in the retrosplenial cortex for resting-state functional magnetic resonance imaging and the Tower of London task. On the other hand, both local and autoinhibitory 5-HT 1A binding inversely modulated the posterior cingulate cortex, the strongest hub in the resting human brain. In the frontal part of the DMN, a negative association was found between the dorsal medial prefrontal cortex and local 5-HT 1A inhibition. Our results indicate a modulation of key areas involved in self-referential processing by serotonergic neurotransmission, whereas variations in 5-HT 1A binding explained a considerable amount of the individual variability in the DMN. Moreover, the brain regions associated with distinct introspective functions seem to be specifically regulated by the different 5-HT 1A binding sites. Together with previously reported modulations of dopamine and GABA, this regional specialization suggests complex interactions of several neurotransmitters driving the default mode network.functional connectivity | resting-state networks | neurotransmitter modulation

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“…In total, PET data from 57 participants from previous work Spindelegger et al, 2008;Stein et al, 2008;Fink et al, 2009;Witte et al, 2009) were used for this retrospective pooled study. Within our patient group, we included 21 medication-free subjects (18 males) between 22 and 56 years of age [mean age (ϮSD), 30.3 Ϯ 7.9 years] with social anxiety (n ϭ 16) or panic disorder (n ϭ 5).…”

Section: Methodsmentioning

confidence: 99%

“…An additional 36 healthy controls (18 males) aged 20 -46 years [mean age (ϮSD), 25.8 Ϯ 4.9 years] were included that have been described in previous studies Fink et al, 2009;Witte et al, 2009). Briefly, all female participants were measured with PET in the follicular phase of their menstrual cycle (Jovanovic et al, 2006), and additional exclusion criteria with respect to patients were any mental, neurological, or psychiatric disorders.…”

Section: Methodsmentioning

confidence: 99%

“…Correct ROI location was ensured using the coregistered magnetic resonance imaging scan. All PET records where then normalized to a tracer-specific template Fink et al, 2009;Witte et al, 2009), and voxel-wise 5-HT 1A receptor maps within the stereotactic Montreal Neurological Institute (MNI) space were computed for assessment of heteroreceptors.…”

Section: Methodsmentioning

confidence: 99%

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