Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells

Zhu, Maguang; Zou, Qin; Huang, Rongxia; Liu, Ying; Xing, Xudong; Fang, Jau–Shiung; Ma, Liang; Li, Lifei; Yang, Xuerui; Yu, Li

doi:10.1038/s41422-020-00415-3

Cited by 78 publications

(100 citation statements)

References 5 publications

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“…Interestingly, one cell’s migrasomes can be collected by surrounding cells, underlying the existence of a lateral transfer of cellular material. Indeed, it is not a long time since Yu’s group demonstrated that migrasomes contain proteins and mRNAs, such as the Pten full-length transcript and protein that can regulate Akt phosphorylation and, thus, proliferation in recipient cells [ 36 ].…”

Section: Migrasome As a Promoter Of Intercellular Communicationmentioning

confidence: 99%

Migrasomes, new vescicles as Hansel and Gretel white pebbles?

2022

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Migrasomes, released by migrating cells, belong to the heterogeneous world of extracellular vesicles (EVs). However, they can be distinguished from all other members of EVs by their size, biorigin and protein cargo. As far as we know, they can play important roles in various communication processes, by mediating the release of signals, such as mRNAs, proteins or damaged mitochondria. To extend and better understand the functional roles and importance of migrasomes, it is first essential to well understand the basic molecular mechanisms behind their formation and function. Herein, we endeavor to provide a brief and up-to-date description of migrasome biogenesis, release, characterization, biological properties and functional activities in cell-to-cell communication, and we will discuss and propose putative new functions for these vesicles.

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Section: Migrasome As a Promoter Of Intercellular Communicationmentioning

confidence: 99%

Migrasomes, new vescicles as Hansel and Gretel white pebbles?

2022

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“…Interorgan communication has been shown to play essential roles in orchestrating metabolic health [5,33]. Mechanistically, bioactive peptides and proteins (e.g., hormones and cytokines), extracellular vesicles (EVs, e.g., exosome and migrasome), and certain nonsecretory genes are the key messengers in modulating the interorgan communication [5,[34][35][36][37][38][39][40][41][42][43]. Moreover, organokines are the novel players mediating the interorgan communication, they are proteins exclusively or predominantly produced by and secreted from a specific tissue (e.g., the functional proteins released from adipose tissue are termed as "adipokines" and skeletal muscle-derived proteins are known as "myokines"), but they are not simply markers of the function of their source tissue, and all organokines have the paracrine or endocrine actions, or both [13].…”

Section: Organ Interaction In Western Medicinementioning

confidence: 99%

“…erefore, both identified and unidentified cardiomyokines and hepatokines might have the interactive network during modulating liver and heart homeostasis. Besides these organokines, EVs (e.g., exosome and migrasome) are the key messengers in interorgan communication, and certain nonsecretory gene-mediated multiple signals are also important in mediating interorgan communication [5,[34][35][36][37][38][39][40][41][42]. However, the network and detail roles of these mediators in modulating hepatocardiac or cardiohepatic interaction still need further investigation.…”

Section: Perspectivementioning

confidence: 99%

Hepatocardiac or Cardiohepatic Interaction: From Traditional Chinese Medicine to Western Medicine

Zhang

Xian-ming

2021

Evidence-Based Complementary and Alternative Medicine

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There is a close relationship between the liver and heart based on “zang-xiang theory,” “five-element theory,” and “five-zang/five-viscus/five-organ correlation theory” in the theoretical system of Traditional Chinese Medicine (TCM). Moreover, with the development of molecular biology, genetics, immunology, and others, the Modern Medicine indicates the existence of the essential interorgan communication between the liver and heart (the heart and liver). Anatomically and physiologically, the liver and heart are connected with each other primarily via “blood circulation.” Pathologically, liver diseases can affect the heart; for example, patients with end-stage liver disease (liver failure/cirrhosis) may develop into “cirrhotic cardiomyopathy,” and nonalcoholic fatty liver disease (NAFLD) may promote the development of cardiovascular diseases via multiple molecular mechanisms. In contrast, heart diseases can affect the liver, heart failure may lead to cardiogenic hypoxic hepatitis and cardiac cirrhosis, and atrial fibrillation (AF) markedly alters the hepatic gene expression profile and induces AF-related hypercoagulation. The heart can also influence liver metabolism via certain nonsecretory cardiac gene-mediated multiple signals. Moreover, organokines are essential mediators of organ crosstalk, e.g., cardiomyokines link the heart to the liver, while hepatokines link the liver to the heart. Therefore, both TCM and Western Medicine, and both the basic research studies and the clinical practices, all indicate that there exist essential “heart-liver axes” and “liver-heart axes.” To investigate the organ interactions between the liver and heart (the heart and liver) will help us broaden and deepen our understanding of the pathogenesis of both liver and heart diseases, thus improving the strategies of prevention and treatment in the future.

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“…Migrasomes contain proteins and mRNAs transferred into recipient cells, where the latter are then translated into proteins that functionally modifying the recipient cell. It is speculated that the lateral mRNA and protein transfer may emerge as a key mechanism through which migrasomes perform their physiological functions (Zhu et al, 2021). Tetraspanin 4 (TSPAN4) has been shown to abound in the migrasome membrane (Stangou & Papagianni, 2015).…”

Section: Migracytosis and Migrasomesmentioning

confidence: 99%

Migrasomes and exosomes; different types of messaging vesicles in podocytes

Ardalan

Khatibi

Saadat

et al. 2021

Cell Biology International

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Podocytes, highly specified kidney epithelial cells, live under several pathological stimuli and stresses during which they adapt themselves to keep homeostasis. Nevertheless, under extreme stress, a complex scenario of podocyte damage and its consequences occur. Podocyte damage causes foot process effacement and their detachment from the glomerular basement membrane, leading to proteinuria. Podocyte‐derived extracellular vesicles (pEVs), mainly microparticles and exosomes are considered as signaling mediators of intercellular communication. Recently, it has been shown that throughout the injury‐related migration procedure, podocytes are capable of releasing the injury‐related migrasomes. Evidence indicates that at the early stages of glomerular disorders, increased levels of pEVs are observed in urine. At the early stage of nephropathy, pEVs especially migrasomes seem to be more sensitive and reliable indicators of podocyte stress and/or damage than proteinuria. This review highlights the current knowledge of pEVs and their values for the diagnosis of different kidney diseases.

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Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells

Cited by 78 publications

References 5 publications

Migrasomes, new vescicles as Hansel and Gretel white pebbles?

Migrasomes, new vescicles as Hansel and Gretel white pebbles?

Hepatocardiac or Cardiohepatic Interaction: From Traditional Chinese Medicine to Western Medicine

Migrasomes and exosomes; different types of messaging vesicles in podocytes

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