Lateral projections of the medial preoptic area are necessary for androgenic influence on urine marking and copulation in rats

Scouten, Charles W.; Burrell, Linda; Palmer, Todd; Cegavske, Craig F.

doi:10.1016/0031-9384(80)90211-5

Cited by 32 publications

(15 citation statements)

References 35 publications

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“…The fact that the time-course of the action of testosterone on the absolute refractory period of MPO-AH neurones in the present experiment is related to the restoration of sexual responses by the hormone does not itself indicate a causal relationship between the two. In conjunction with similar results which have been reported previously for CMA neurones , however, this finding is clearly suggestive of a causal relationship, particularly in view of the fact that it is essential for both sets of neuronal projections to be intact for the male to show normal copulatory responses (CMA, Harris & Sachs, 1975;MFB, Szechtman et al 1978;Scouten et al 1980). While the exact nature of the information being transmitted to the MPO-AH from the CMA and equally from the MPO-AH into the MFB is unknown, there are data indicating that the changes in the neuronal refractory period after castration are correlated with a reduced ability by these neurones to respond to their inputs (Kendrick, 1982a).…”

Section: Resultssupporting

confidence: 83%

“…There is evidence that the MPO-AH exerts its modulatory effects on male sexual behaviour by means of the medial forebrain bundle (MFB). Knife-cuts severing the connections between the MPO-AH and the MFB produce a disruption of sexual behaviour in the male rat as severe as that observed after MPO-AH lesions (Szechtman, Caggiula & Wulkan, 1978;Scouten, Burrell, Palmer & Cegavske, 1980). Noradrenergic, 5-hydroxytryptaminergic and dopaminergic pathways also run from cell bodies in the midbrain to the MPO-AH, septum, CMA and other hypothalamic regions by means of the MFB (Ungerstedt, 1971).…”

Section: Introductionmentioning

confidence: 99%

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Electrophysiological effects of testosterone on the medial preoptic–anterior hypothalamus of the rat

Kendrick¹

1983

Journal of Endocrinology

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Castration in the rat significantly lengthened the refractory period of medial preoptic-anterior hypothalamic neurones with outputs into the medial forebrain bundle but not of those with outputs to the lateral septum. Treatment with testosterone propionate reduced the neuronal refractory period to its lowest level at the same time as it restored mounts and intromissions (after 5 days). Equally, when treatment was ended at 15 days, mounts and intromissions were no longer shown when the refractory period lengthened again 14 days later. The sub-population of neurones which also received inputs from the contralateral fimbria (through the corticomedial amygdala) showed the same results as the overall population. Castration also significantly increased the baseline firing rates of medial preoptic-anterior hypothalamic neurones receiving inputs from the medial forebrain bundle. The same effect was observed for the sub-population of neurones which also had inputs from the contralateral fimbria, but castration significantly reduced the percentage of neurones responding to this additional input. The neurones having inputs with the fastest conduction velocity were responsible for these changes in firing rate and the input neurones were therefore probably non-dopaminergic.

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Section: Resultssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Electrophysiological effects of testosterone on the medial preoptic–anterior hypothalamus of the rat

Kendrick¹

1983

Journal of Endocrinology

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“…However, such a direct projection has been described for the dorsolateral part of the preoptic area only (Holstege, 1987). It should be emphasized that, in territorial and sexual behavior in many animals, micturition is of great importance and that the preoptic area is known to play a role in these behaviors (Grossman and Wang, 1955;Malsbury, 1971;Powers and Valenstein, 1972;Scouten et al, 1980). Structures belonging to the lateral component of the emotional motor system, such as the central nucleus of the amygdala (Hopkins and Holstege, 1978), the bed nucleus of the stria terminalis (Holstege et al, 1985), and the lateral hypothalamus as well as the preoptic area (Holstege, 1987), project heavily to the lateral part of the caudal PAG.…”

Section: Emotional Motor System and The Control Of Micturitionmentioning

confidence: 99%

Ultrastructural evidence for a paucity of projections from the lumbosacral cord to the pontine micturition center or M‐region in the cat: A new concept for the organization of the micturition reflex with the periaqueductal gray as central relay

Blok

Weerd

Holstege

1995

J of Comparative Neurology

189

102

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Information concerning the rate of bladder filling is determined by receptors in the bladder wall and conveyed via afferent fibers in the pelvic nerve to sensory neurons in the lumbosacral cord. It was assumed that this information is relayed from the lumbosacral cord to a medial cell group in the dorsolateral pontine tegmentum, called the M-region, the pontine micturition center, or Barrington's nucleus. The M-region, in turn, projects via long descending pathways to the sacral parasympathetic motoneurons. In the present electron microscopic study, it was investigated in cats whether monosynaptic projections from lumbosacral neurons to the M-region indeed exist. Wheat-germ agglutinin-horseradish peroxidase injections were made into the lumbosacral cord. Many retrogradely labeled dendrites and somata were found in the M-region, but no labeled terminals were found on retrogradely labeled dendrites or somata. Only a small number of anterogradely labeled terminals, which were filled with mainly round vesicles, contacted unlabeled dendrites in the M-region. In contrast, many more anterogradely labeled terminals, which were filled with mainly round and, to a limited extent, dense core vesicles and with asymmetrical synapses, were found on dendrites in the lateral part of the periaqueductal gray (PAG). Previously (Blok and Holstege [1994] Neurosci. Lett. 166:93-96), it was demonstrated that the lateral part of the PAG contains neurons projecting to the M-region. A concept for the central organization of the micturition reflex is presented in which ascending projections from the lumbosacral cord convey information on bladder filling to the PAG.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Using either technique, scent-marking scores decrease after castration but increase again if the castrates are given inJections ofTPor subcutaneous implants of testosterone (Brown, 1977(Brown, , 1978Price, 1975;Scouten, Burrell, Palmer, & Cegavske, 1980). As is the case for mice, no data are available on dose-response relationships for maintaining or reinstating the behavior.…”

Section: Urine-marking In Ratsmentioning

confidence: 99%

Hormonal Influences on Territorial Marking Behavior

Yahr

1983

Hormones and Aggressive Behavior

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Lateral projections of the medial preoptic area are necessary for androgenic influence on urine marking and copulation in rats

Cited by 32 publications

References 35 publications

Electrophysiological effects of testosterone on the medial preoptic–anterior hypothalamus of the rat

Electrophysiological effects of testosterone on the medial preoptic–anterior hypothalamus of the rat

Ultrastructural evidence for a paucity of projections from the lumbosacral cord to the pontine micturition center or M‐region in the cat: A new concept for the organization of the micturition reflex with the periaqueductal gray as central relay

Hormonal Influences on Territorial Marking Behavior

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