Late Sequelae of COVID-19 Infection in Patients Without Comorbidities

Adame, María; Nada, Khaled M.; Seashore, Justin

doi:10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3821

Cited by 3 publications

(15 citation statements)

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“…Table 1 shows the details of the included studies with the study design, type of population, symptoms, duration, and the information provided. 13 – 62 Supplemental Table 2 shows the excluded studies with reasons of exclusion.…”

Section: Resultsmentioning

confidence: 99%

“…The overall frequency of GI symptoms was reported in 14 studies involving 296,487 patients. 13 , 14 , 27 , 28 , 39 , 40 , 42 , 45 , 48 , 49 , 51 , 55 , 59 , 60 The frequency of overall GI symptoms in patients with COVID-19 was 0.12 [95% confidence interval (CI), 0.06–0.22, I 2 = 99%] ( Figure 2 ). The frequency of GI symptoms in long COVID was reported in 12 studies (158,731 patients).…”

Section: Resultsmentioning

confidence: 99%

“…The frequency of GI symptoms in long COVID was reported in 12 studies (158,731 patients). 13 , 14 , 27 , 28 , 39 , 40 , 42 , 45 , 51 , 52 , 53 , 55 The frequency of GI symptoms in patients with long COVID was 0.22 (95% CI, 0.10–0.41, I 2 = 97%) ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…The frequency of GI long-COVID symptoms in patients with severe COVID-19 was 0.13 (95% CI, 0.04–0.34, I 2 = 99%) (five studies, 19,067 patients) 40 , 48 , 49 , 51 , 60 ( Supplemental Figure 1 ). The frequency was 0.14 (95% CI, 0.05–0.34, I 2 = 98%) in studies reporting mixed disease severity (severe as well as non-severe disease) 13 , 14 , 39 , 42 , 45 , 55 , 59 ( Supplemental Figure 1 ). Similarly, the frequency of GI manifestations in patients having long COVID after severe COVID infection was 0.20 (95% CI, 0.12–0.32, I 2 = 71%) 40 , 51 , 52 ( Supplemental Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…The frequency of GI manifestations in patients with long COVID as per WHO definition was 0.28 (95% CI, 0.15–0.46, I 2 = 97%) 39 , 40 , 42 , 45 , 51 , 52 , 55 ( Supplemental Figure 3 ). The frequency of GI manifestations in patients with COVID-19 as per NICE/CDC definition was 0.14 (95% CI, 0.06–0.28, I 2 = 99%) 13 , 14 , 39 , 40 , 42 , 45 , 48 , 49 , 51 , 59 , 60 ( Supplemental Figure 4 ). The frequency of GI manifestations in patients with long COVID as per NICE/CDC definition was 0.26 (95% CI, 0.11–0.50, I 2 = 96%) 13 , 14 , 39 , 40 , 42 , 45 , 51 , 52 , 53 , 55 ( Supplemental Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

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Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Choudhury

Tariq

Jena

et al. 2022

Therap Adv Gastroenterol

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Background: Prolonged symptoms after COVID-19 are an important concern due to the large numbers affected by the pandemic. Objectives: To ascertain the frequency of gastrointestinal (GI) manifestations as part of long GI COVID. Design: A systematic review and meta-analysis of studies reporting GI manifestations in long COVID was performed. Data Sources and Methods: Electronic databases (Medline, Scopus, Embase, Cochrane Central Register of Controlled Trials, and Web of Science) were searched till 21 December 2021 to identify studies reporting frequency of GI symptoms in long COVID. We included studies reporting overall GI manifestations or individual GI symptoms as part of long COVID. We excluded pediatric studies and those not providing relevant information. We calculated the pooled frequency of various symptoms in all patients with COVID-19 and also in those with long COVID using the inverse variance approach. All analysis was done using R version 4.1.1 using packages ‘meta’ and ‘metafor’. Results: A total of 50 studies were included. The frequencies of GI symptoms were 0.12 [95% confidence interval (CI), 0.06–0.22, I2 = 99%] and 0.22 (95% CI, 0.10–0.41, I2 = 97%) in patients with COVID-19 and those with long COVID, respectively. The frequencies of abdominal pain, nausea/vomiting, loss of appetite, and loss of taste were 0.14 (95% CI, 0.04–0.38, I2 = 96%), 0.06 (95% CI, 0.03–0.11, I2 = 98%), 0.20 (95% CI, 0.08–0.43, I2 = 98%), and 0.17 (95% CI, 0.10–0.27, I2 = 95%), respectively, after COVID-19. The frequencies of diarrhea, dyspepsia, and irritable bowel syndrome were 0.10 (95% CI, 0.04–0.23, I2 = 98%), 0.20 (95% CI, 0.06–0.50, I2 = 97%), and 0.17 (95% CI, 0.06–0.37, I2 = 96%), respectively. Conclusion: GI symptoms in patients were seen in 12% after COVID-19 and 22% as part of long COVID. Loss of appetite, dyspepsia, irritable bowel syndrome, loss of taste, and abdominal pain were the five most common GI symptoms of long COVID. Significant heterogeneity and small number of studies for some of the analyses are limitations of the systematic review.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Choudhury

Tariq

Jena

et al. 2022

Therap Adv Gastroenterol

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The Multisystem Impact of Long COVID: A Comprehensive Review

Negrut,

Georgios,

Kampioti

et al. 2024

Preprint

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(1) Background: COVID-19 was responsible for the latest pandemic, shaking and reshaping healthcare systems worldwide. Its late clinical manifestations make it linger in medical memory as a debilitating illness over extended periods. (2) Methods: Recent literature was systematically analyzed to categorize and examine the symptomatology and pathophysiology of Long COVID across various bodily systems, including pulmonary, cardiovascular, gastrointestinal, neuropsychiatric, dermatological, renal, hematological, and endocrinological aspects. (3) Results: The review outlines the diverse clinical manifestations of Long COVID across multiple systems, emphasizing its complexity and challenges in diagnosis and treatment. Factors such as pre-existing conditions, initial COVID-19 severity, vaccination status, gender, and age were identified as influential in the manifestation and persistence of Long COVID symptoms. This condition is highlighted as a debilitating disease capable of enduring over an extended period and presenting new symptoms over time. (4) Conclusions: Long COVID emerges as a condition with intricate multi-systemic involvement, complicating its diagnosis and treatment. The findings underscore the necessity for a nuanced understanding of its diverse manifestations to effectively manage and address the evolving nature of this condition over time.

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The Multisystem Impact of Long COVID: A Comprehensive Review

Negrut,

Menegas,

Kampioti

et al. 2024

Diagnostics

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(1) Background: COVID-19 was responsible for the latest pandemic, shaking and reshaping healthcare systems worldwide. Its late clinical manifestations make it linger in medical memory as a debilitating illness over extended periods. (2) Methods: the recent literature was systematically analyzed to categorize and examine the symptomatology and pathophysiology of Long COVID across various bodily systems, including pulmonary, cardiovascular, gastrointestinal, neuropsychiatric, dermatological, renal, hematological, and endocrinological aspects. (3) Results: The review outlines the diverse clinical manifestations of Long COVID across multiple systems, emphasizing its complexity and challenges in diagnosis and treatment. Factors such as pre-existing conditions, initial COVID-19 severity, vaccination status, gender, and age were identified as influential in the manifestation and persistence of Long COVID symptoms. This condition is highlighted as a debilitating disease capable of enduring over an extended period and presenting new symptoms over time. (4) Conclusions: Long COVID emerges as a condition with intricate multi-systemic involvement, complicating its diagnosis and treatment. The findings underscore the necessity for a nuanced understanding of its diverse manifestations to effectively manage and address the evolving nature of this condition over time.

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Late Sequelae of COVID-19 Infection in Patients Without Comorbidities

Cited by 3 publications

References 0 publications

Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis

The Multisystem Impact of Long COVID: A Comprehensive Review

The Multisystem Impact of Long COVID: A Comprehensive Review

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