Late-onset, warfarin-caused necrosis occurring in a patient with infectious mononucleosis

Localized cutaneous necrosis associated with the antiphospholipid syndrome

“…Skin lesions in WISN usually appear 3–6 days after commencing warfarin, but our patient had commenced warfarin 2 years previously 11 . There have been a small number of reports of skin necrosis occurring in patients who have been taking warfarin for up to 15 years, which has been referred to as ‘late‐onset WISN’ 12–15 . However the mechanism of necrosis in these patients has not been determined, and the possibility of non‐warfarin‐related causes in such cases needs to be considered 12 .…”

Cutaneous Necrosis Associated with the Lupus Anticoagulant

“…The clinical similarity of the necrotic lesions of our 3 patients and those of patients with protein C deficiencies led to an analysis of the physiopathology of the LA [17][18][19][20],…”

An Atypical Case of Warfarin-Induced Skin Necrosis

“…However, there are documented cases of warfarin-induced skin necrosis occurring months to years after the initiation of warfarin. 2 , 3 , 5 – 7 Many of these late-onset cases involved patients who were predisposed to prothrombotic states. 2 , 3 , 8 , 9 Furthermore, there have been three reported cases of warfarin-induced skin necrosis upon warfarin recommencement in warfarin non-naïve patients with no prior complications.…”