Intern. Med. volume 35, issue 8, P641-645 1996 DOI: 10.2169/internalmedicine.35.641 View full text
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Hiroaki MIYAJIMA, Yoshitomo TAKAHASHI, Hideaki SHIMIZU, Naoki SAKAI, Tadashi KAMATA, Eizo KANEKO

Abstract: Aceruloplasminemia is a systemic degenerative disorder characterized by mutations in the ceruloplasmin gene, the absence of serum ceruloplasmin, and iron accumulation in the brain, liver, and other tissues. Iron is an important catalyst of oxyradical-mediated cellular and tissue injury, and (3-cells in the pancreatic islets are susceptible to the cytotoxic effects of oxidative stress. We report three patients with aceruloplasminemia who have late-onset diabetes mellitus (DM) and impaired glucose tolerance (IG…

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