Late (≥ 7 days) inhalation corticosteroids to reduce bronchopulmonary dysplasia in preterm infants

Early Intratracheal Administration of Corticosteroid and Pulmonary Surfactant for Preventing Bronchopulmonary Dysplasia in Preterm Infants with Neonatal Respiratory Distress Syndrome: A Meta-analysis

“…Yeh's study [6] confirmed that a mixture of PS and budesonide suspension not only improved drug delivery but also had a synergistic clinical benefit. The results of our meta-analysis showed that the combined application of glucocorticoids and PS in the airway after NRDS can reduce the occurrence of BPD and mortality incidence in premature infants, and reduce the likehood of using PS more than one time, which is consistent with the published meta-analysis [29][30][31][32] . In this meta-analysis, we further found that the combination of ICS and PS by intratracheal instillation can reduce the mortality of BPD in premature infants with confirmed NRDS.…”

Early Intratracheal Administration of Corticosteroid and Pulmonary Surfactant for Preventing Bronchopulmonary Dysplasia in Preterm Infants with Neonatal Respiratory Distress Syndrome: A Meta-analysis

“…Yeh's study [6] confirmed that a mixture of PS and budesonide suspension not only improved drug delivery but also had a synergistic clinical benefit. The results of our meta-analysis showed that the combined application of glucocorticoids and PS in the airway after NRDS can reduce the occurrence of BPD and mortality incidence in premature infants, and reduce the likehood of using PS more than one time, which is consistent with the published meta-analysis [29][30][31][32] . In this meta-analysis, we further found that the combination of ICS and PS by intratracheal instillation can reduce the mortality of BPD in premature infants with confirmed NRDS.…”

Effect of airway administration of budesonide for bronchopulmonary dysplasia in premature infants: A Systematic Review and Meta-Analysis

“…Therefore, earlier airway administration of budesonide might be preferred to reduce lung injury and BPD. AS for the late intervention time of included studies in our meta-analysis is at the 3 rd and 7 th day after birth, we draw a similar conclusion with Onland W et al [10], but this conclusion should be interpreted with caution because the number of infants is small.…”

Hydrocortisone use in ventilated extremely preterm infants decreased bronchopulmonary dysplasia with no effects on neurodevelopment after two years

“…It is difficult to interpret the impact of inhaled corticosteroids in our study because late inhaled corticosteroids, defined as after six days of life, have not been proved to have any beneficial effect so far as opposed to early inhaled corticosteroids . However, it should be noted that inhaled steroids were more frequently prescribed in centre P.…”

Early Intratracheal Administration of Corticosteroid and Pulmonary Surfactant for Preventing Bronchopulmonary Dysplasia in Preterm Infants with Neonatal Respiratory Distress Syndrome: A Meta-analysis

“…Yeh's study [6] confirmed that a mixture of PS and budesonide suspension not only improved drug delivery but also had a synergistic clinical benefit. The results of our meta-analysis showed that the combined application of glucocorticoids and PS in the airway after NRDS can reduce the occurrence of BPD and mortality incidence in premature infants, and reduce the likehood of using PS more than one time, which is consistent with the published meta-analysis [29][30][31][32] . In this meta-analysis, we further found that the combination of ICS and PS by intratracheal instillation can reduce the mortality of BPD in premature infants with confirmed NRDS.…”

Effect of airway administration of budesonide for bronchopulmonary dysplasia in premature infants: A Systematic Review and Meta-Analysis

“…Therefore, earlier airway administration of budesonide might be preferred to reduce lung injury and BPD. AS for the late intervention time of included studies in our meta-analysis is at the 3 rd and 7 th day after birth, we draw a similar conclusion with Onland W et al [10], but this conclusion should be interpreted with caution because the number of infants is small.…”

Hydrocortisone use in ventilated extremely preterm infants decreased bronchopulmonary dysplasia with no effects on neurodevelopment after two years

“…It is difficult to interpret the impact of inhaled corticosteroids in our study because late inhaled corticosteroids, defined as after six days of life, have not been proved to have any beneficial effect so far as opposed to early inhaled corticosteroids . However, it should be noted that inhaled steroids were more frequently prescribed in centre P.…”

Early Intratracheal Administration of Corticosteroid and Pulmonary Surfactant for Preventing Bronchopulmonary Dysplasia in Preterm Infants with Neonatal Respiratory Distress Syndrome: A Meta-analysis

“…Yeh's study [6] confirmed that a mixture of PS and budesonide suspension not only improved drug delivery but also had a synergistic clinical benefit. The results of our meta-analysis showed that the combined application of glucocorticoids and PS in the airway after NRDS can reduce the occurrence of BPD and mortality incidence in premature infants, and reduce the likehood of using PS more than one time, which is consistent with the published meta-analysis [29][30][31][32] . In this meta-analysis, we further found that the combination of ICS and PS by intratracheal instillation can reduce the mortality of BPD in premature infants with confirmed NRDS.…”

Effect of airway administration of budesonide for bronchopulmonary dysplasia in premature infants: A Systematic Review and Meta-Analysis

“…Therefore, earlier airway administration of budesonide might be preferred to reduce lung injury and BPD. AS for the late intervention time of included studies in our meta-analysis is at the 3 rd and 7 th day after birth, we draw a similar conclusion with Onland W et al [10], but this conclusion should be interpreted with caution because the number of infants is small.…”

Hydrocortisone use in ventilated extremely preterm infants decreased bronchopulmonary dysplasia with no effects on neurodevelopment after two years

“…It is difficult to interpret the impact of inhaled corticosteroids in our study because late inhaled corticosteroids, defined as after six days of life, have not been proved to have any beneficial effect so far as opposed to early inhaled corticosteroids . However, it should be noted that inhaled steroids were more frequently prescribed in centre P.…”